Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Thomas A. Skipper"'
Autor:
Carolina Mejia Peña, Thomas A. Skipper, Jeffrey Hsu, Ilexa Schechter, Deepraj Ghosh, Michelle R. Dawson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract More than 75% of epithelial ovarian cancer (EOC) patients experience disease recurrence after initial treatment, highlighting our incomplete understanding of how chemoresistant populations evolve over the course of EOC progression post chemo
Externí odkaz:
https://doaj.org/article/106dfd1382ea47bab23a37b55c989937
Autor:
Daniel P. Bondeson, Zachary Mullin-Bernstein, Sydney Oliver, Thomas A. Skipper, Thomas C. Atack, Nolan Bick, Meilani Ching, Andrew A. Guirguis, Jason Kwon, Carly Langan, Dylan Millson, Brenton R. Paolella, Kevin Tran, Sarah J. Wie, Francisca Vazquez, Zuzana Tothova, Todd R. Golub, William R. Sellers, Alessandra Ianari
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Conditional Degron Tags are a valuable tool to validate and study novel therapeutic targets. Here, the authors compared 5 orthogonal tags across 16 unique proteins and provide a panel of vectors for users to systematically screen the tags with their
Externí odkaz:
https://doaj.org/article/3e22ee8eab4c40c2a32562f1d4989057
Autor:
Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Annan Yang, Radha L. Kalekar, John M. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Jérémie Kalfon, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Adam D. Durbin, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109367- (2021)
Externí odkaz:
https://doaj.org/article/ac506d36e0fc45f58afd5108c6469b14
Autor:
Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Annan Yang, Radha L. Kalekar, John M. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Jérémie Kalfon, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Adam D. Durbin, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108493- (2020)
Summary: Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new therapeutic targets associated with genomic loss of tumor suppressor genes. The endosom
Externí odkaz:
https://doaj.org/article/8d45f5f857914e55852e4f26974a4071
Autor:
Daniel P. Bondeson, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Carly Langan, Gabriel Mesa, Alfredo Gonzalez, Lauren E. Surface, Kentaro Ito, Mariya Kazachkova, William N. Colgan, Allison Warren, Joshua M. Dempster, John M. Krill-Burger, Maria Ericsson, Andrew A. Tang, Iris Fung, Emily S. Chambers, Mai Abdusamad, Nancy Dumont, John G. Doench, Federica Piccioni, David E. Root, Jesse Boehm, William C. Hahn, Michael Mannstadt, James M. McFarland, Francisca Vazquez, Todd R. Golub
Publikováno v:
Nature Cancer. 3:681-695
Despite advances in precision medicine, the clinical prospects for patients with ovarian and uterine cancers have not substantially improved. Here, we analyzed genome-scale CRISPR-Cas9 loss-of-function screens across 851 human cancer cell lines and f
Autor:
Radha L. Kalekar, Francisca Vazquez, Jesse S. Boehm, Thomas A. Skipper, Andrew J. Aguirre, Andrew L. Hong, Chen Yuan, Todd R. Golub, Guillaume Kugener, Westley W. Wu, Kimberly Stegmaier, Adam D. Durbin, Nancy Dumont, Michael V. Rothberg, Jasper E. Neggers, David E. Root, Neekesh V. Dharia, Mai Abdusamad, Andrew D. Cherniack, Adhana Asfaw, Brian M. Wolpin, Jeremie Kalfon, Liam F. Spurr, Brenton R. Paolella, Alfredo Gonzalez, William C. Hahn, Aviad Tsherniak, John M. Krill-Burger, Federica Piccioni, Annan Yang, Yvonne Y. Li
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108493-(2020)
Cell reports
Cell Reports, Vol 36, Iss 2, Pp 109367-(2021)
Cell reports
Cell Reports, Vol 36, Iss 2, Pp 109367-(2021)
SUMMARY Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new therapeutic targets associated with genomic loss of tumor suppressor genes. The endosoma
Autor:
Federica Piccioni, Neekesh V. Dharia, Michael J. Krill-Burger, Aviad Tsherniak, Andrew L. Hong, Andrew J. Aguirre, Thomas A. Skipper, Guillaume Kugener, Jesse S. Boehm, Jasper E. Neggers, Kimberly Stegmaier, Michael V. Rothberg, Adam D. Durbin, Brenton R. Paolella, Francisca Vazquez, Nancy Dumont, Todd R. Golub, David E. Root, Radha L. Kalekar, William C. Hahn, Brian M. Wolpin, Adhana Asfaw, Andrew D. Cherniack, Yvonne Y. Li, Annan Yang
Publikováno v:
Cancer Research. 80:PO-011
Somatic copy number alterations that result in loss of tumor suppressor gene function are important drivers of tumorigenesis. However, few existing therapeutic options to target oncogenic processes evoked by tumor suppressor gene inactivation exist.
Autor:
A. Tscherniak, Michael V. Rothberg, K. Jérémie, A. Hong, D. Nancy, Michael Burger, A. Yang, William C. Hahn, Andrew D. Cherniack, Todd R. Golub, Francisca Vazquez, Guillaume Kugener, Brenton R. Paolella, Adhana Asfaw, Jasper E. Neggers, Radha L. Kalekar, Kimberly Stegmaier, Andrew J. Aguirre, Mai Abdusamad, Thomas A. Skipper
Publikováno v:
European Journal of Cancer. 138:S8
Autor:
Thomas A. Skipper, Radha L. Kalekar, Guillaume Kugener, Aviad Tsherniak, David E. Root, Yvonne Y. Li, Brian M. Wolpin, Alfredo Gonzalez, Michael V. Rothberg, Jesse S. Boehm, Andrew L. Hong, Andrew J. Aguirre, Todd R. Golub, Jasper E. Neggers, Chen Yuan, Jeremie Kalfon, Mai Abdusamad, Liam F. Spurr, Brenton R. Paolella, Westley W. Wu, Nancy Dumont, Annan Yang, Francisca Vazquez, Adhana Asfaw, Andrew D. Cherniack, John M. Krill-Burger, Federica Piccioni
Publikováno v:
Cancer Research. 80:LB-053
Somatic copy number alterations that result in loss of tumor suppressor gene function are important drivers of tumorigenesis. However, few existing therapeutic options to target oncogenic processes evoked by tumor suppressor gene inactivation exist.