Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Thomas A. Shell"'
Autor:
Hannah L. Cure, Thomas A. Shell
Publikováno v:
Results in Chemistry, Vol 13, Iss , Pp 101918- (2025)
Substituting hydrogen atoms with fluorine alters physicochemical properties often resulting in improved drug action relative to the parent molecule. The high electronegativity of fluorine changes the electron density distribution of the molecule; how
Externí odkaz:
https://doaj.org/article/01f7a852313b4a5ca1476e753ec34bdb
Publikováno v:
Journal of Photochemistry and Photobiology, Vol 18, Iss , Pp 100209- (2023)
Agents that cause double-strand breaks (DSBs) of DNA via radical formation have been demonstrated to be effective in treating cancer because DSBs result in cellular apoptosis. Light-responsive agents for the treatment of cancer have been of interest
Externí odkaz:
https://doaj.org/article/0b7096922d46409a8ff8f68234eccf56
Autor:
Joshua A. Boldon, Thomas A. Shell
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 101129- (2023)
Acetaminophen (N-acetyl-para-aminophenol, APAP) is a commonly used analgesic and antipyretic drug. While acetaminophen is generally safe when taken at therapeutic doses, it causes severe liver and kidney damage at overdose quantities. Cytochromes P-4
Externí odkaz:
https://doaj.org/article/6cbcc01541bd403b9c5caf528be52411
Autor:
Joshua A. Boldon, Thomas A. Shell
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 101075- (2023)
Acedoben (4-acetamidobenzoic acid, AcPABA) is a component of the antiviral drug inosine pranobex. The introduction of fluorine has been proven to change the physicochemical properties of molecules. For example, the trifluoromethyl group generally imp
Externí odkaz:
https://doaj.org/article/fe519aada96e4c07b3b9ded5a94fdef3
Autor:
Liberty N. Gendron, Dillon C. Zites, Ethan P. M. LaRochelle, Jennifer R. Shell, Jason R. Gunn, Thomas A. Shell, Brian W. Pogue
Publikováno v:
Photodiagnosis Photodyn Ther
Background X-Ray induced phototherapy is highly sought after as it provides a deep tissue, synergistic method of treating cancers via standard-of-care radiotherapy. When this is combined with releasable chemotherapy agents, it can provide high target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7441a0f25769b98afd48772ba119e019
https://europepmc.org/articles/PMC7505481/
https://europepmc.org/articles/PMC7505481/
Publikováno v:
17th International Photodynamic Association World Congress.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccd05a5e1d270241403c8c4f9d57ca5d
https://doi.org/10.1117/12.2528263
https://doi.org/10.1117/12.2528263
Publikováno v:
17th International Photodynamic Association World Congress.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0be379f6256077e2d012f4756be37571
https://doi.org/10.1117/12.2528271
https://doi.org/10.1117/12.2528271
Publikováno v:
Molecular-Guided Surgery: Molecules, Devices, and Applications V.
The discovery of new tumor targeting agents is desirable to expand imaging and drug delivery platforms. Cobalamins, vitamin B12 derivatives, selectively accumulate in tumor versus benign tissue due to overexpression of transcobalamin receptors in a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc3327036280ed72b54d96876a7b5f98
https://doi.org/10.1117/12.2515379
https://doi.org/10.1117/12.2515379