B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis

Autor: Prasad Srikakulapu, Tanyaporn Pattarabanjird, Aditi Upadhye, Sai Vineela Bontha, Victoria Osinski, Melissa A. Marshall, James Garmey, Justine Deroissart, Thomas A. Prohaska, Joseph L. Witztum, Christoph J. Binder, Nichol E. Holodick, Thomas L. Rothstein, Coleen A. McNamara

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Immunoglobulin M (IgM) to oxidation specific epitopes (OSE) are inversely associated with atherosclerosis in mice and humans. The B-1b subtype of B-1 cells secrete IgM to OSE, and unlike B-1a cells, are capable of long-lasting IgM memory. What attrib

Externí odkaz: https://doaj.org/article/286501d5bfa64c20ac2f25408827ca76

Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs

Autor: Zeyang Shen, Rick Z Li, Thomas A Prohaska, Marten A Hoeksema, Nathan J Spann, Jenhan Tao, Gregory J Fonseca, Thomas Le, Lindsey K Stolze, Mashito Sakai, Casey E Romanoski, Christopher K Glass

Publikováno v: eLife, Vol 11 (2022)

Regulation of gene expression requires the combinatorial binding of sequence-specific transcription factors (TFs) at promoters and enhancers. Prior studies showed that alterations in the spacing between TF binding sites can influence promoter and enh

Externí odkaz: https://doaj.org/article/98d44d7ff9f64f50bf3ced74f1b45425

APOC3 inhibition with volanesorsen reduces hepatic steatosis in patients with severe hypertriglyceridemia

Autor: Thomas A. Prohaska, Veronica J. Alexander, Ewa Karwatowska-Prokopczuk, Joseph Tami, Shuting Xia, Joseph L. Witztum, Sotirios Tsimikas

Publikováno v: Journal of Clinical Lipidology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4057abe644298dc6a620d6d97fc0cf2b
https://doi.org/10.1016/j.jacl.2023.04.007

Highlights From an Expert Meeting on Opportunities for Cancer Prevention Among Older Adults

Autor: Elisa Epel, Erwin J. Tan, Roland J. Thorpe, David X. Marquez, Michele Marcus, Linda Rhodes, Thomas R. Prohaska, Paige A. Green, Sei J. Lee, Reginald D. Tucker-Seeley, Peggy Toy, Robyn I. Stone, Dilip V. Jeste, Siran M. Koroukian, Dawn M. Holman, Eugene J. Lengerich, Rima E. Rudd

Publikováno v: Gerontologist

This paper provides highlights from an expert meeting to explore opportunities to reduce cancer risk and promote health at older ages. Factors that increase cancer risk among older adults include exposure to carcinogens from multiple sources, chronic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fde28845867da847516f6f958f28c7
https://doi.org/10.1093/geront/gnz037

Consensus statement: loneliness in older adults, the 21st century social determinant of health?

Autor: Annette Burns, Jeannette Golden, Gerard Leavey, Louise C. Hawkley, Theo G. van Tilburg, Thomas R. Prohaska, Roger O’Sullivan, Vanessa Burholt, Carla Perissinotto, Linda P. Fried, Christina R. Victor, Jim Lubben, Mark A. Tully, Brian A. Lawlor

Publikováno v: BMJ Open, Vol 10, Iss 8 (2020)
BMJ Open, 10(8):e034967. BMJ Publishing Group
Prohaska, T, Burholt, V, Burns, A, Golden, J, Hawkley, L, Lawlor, B A, Leavey, G, Lubben, J, O'Sullivan, R, Perissinotto, C, van Tilburg, T G, Tully, M, Victor, C & Fried, L 2020, ' Consensus statement: Loneliness in older adults, the 21st century social determinant of health ', BMJ Open, vol. 10, no. 8, e034967, pp. e034967 . https://doi.org/10.1136/bmjopen-2019-034967
BMJ Open

ObjectiveThe purpose of this consensus statement is to determine the state of the field of loneliness among older people, highlighting key issues for researchers, policymakers and those designing services and interventions.MethodsIn December 2018, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e3a55b7ee58eb28560cedce516de49
https://bura.brunel.ac.uk/handle/2438/21132