Zobrazeno 1 - 10
of 540
pro vyhledávání: '"Thomas A. Poulsen"'
Autor:
Thomas Holst-Hansen, Pernille Yde Nielsen, Mogens H. Jensen, Thomas Mandrup-Poulsen, Ala Trusina
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Type 2 diabetes (T2D) is associated with a systemic increase in the pro-inflammatory cytokine IL-1β. While transient exposure to low IL-1β concentrations improves insulin secretion and β-cell proliferation in pancreatic islets, prolonged
Externí odkaz:
https://doaj.org/article/a2ec5519be3141949357ae26ecb70924
Autor:
Naziia Kurmasheva, Aida Said, Boaz Wong, Priscilla Kinderman, Xiaoying Han, Anna H. F. Rahimic, Alena Kress, Madalina E. Carter-Timofte, Emilia Holm, Demi van der Horst, Christoph F. Kollmann, Zhenlong Liu, Chen Wang, Huy-Dung Hoang, Elina Kovalenko, Maria Chrysopoulou, Krishna Sundar Twayana, Rasmus N. Ottosen, Esben B. Svenningsen, Fabio Begnini, Anders E. Kiib, Florian E. H. Kromm, Hauke J. Weiss, Daniele Di Carlo, Michela Muscolini, Maureen Higgins, Mirte van der Heijden, Angelina Bardoul, Tong Tong, Attila Ozsvar, Wen-Hsien Hou, Vivien R. Schack, Christian K. Holm, Yunan Zheng, Melanie Ruzek, Joanna Kalucka, Laureano de la Vega, Walid A. M. Elgaher, Anders R. Korshoej, Rongtuan Lin, John Hiscott, Thomas B. Poulsen, Luke A. O’Neill, Dominic G. Roy, Markus M. Rinschen, Nadine van Montfoort, Jean-Simon Diallo, Henner F. Farin, Tommy Alain, David Olagnier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor, potentially leading to treatmen
Externí odkaz:
https://doaj.org/article/cf343351f5cf4766ad351ee93729ee99
Autor:
Seyed M. Ghiasi, Piero Marchetti, Lorenzo Piemonti, Jens H. Nielsen, Bo T. Porse, Thomas Mandrup-Poulsen, Guy A. Rutter
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionProinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. Here, we investig
Externí odkaz:
https://doaj.org/article/bafcdcd0a3234dbca050690609495367
Autor:
David Bajor, Nashat Gabrail, Alain Algazi, Diwakar Davar, Douglas Laux, Morteza Aghmesheh, Joan Morris, Vinod Ganju, Vibeke Miller Breinholt, Mette Kriegbaum, Alexander I Spira, Christian Krapp, Telma Lança, Stina Singel, Thomas Tuxen Poulsen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/69f075075b164ef298aa8033a3763d55
Autor:
Mathis Mottelson, Jens Helby, Børge Grønne Nordestgaard, Christina Ellervik, Thomas Mandrup-Poulsen, Jesper Petersen, Stig Egil Bojesen, Andreas Glenthøj
Publikováno v:
HemaSphere, Vol 7, p e7367624 (2023)
Externí odkaz:
https://doaj.org/article/fa4d9c99c8574fca9d852754b54d2058
Autor:
Malene Wollesen, Kasper Mikkelsen, Marie Selch Tvilum, Martin Vestergaard, Mikala Wang, Rikke L. Meyer, Hanne Ingmer, Thomas B. Poulsen, Thomas Tørring
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Polyether ionophores are complex natural products known to transport various cations across biological membranes. While several members of this family are used in agriculture (e.g., as anti-coccidiostats) and have potent antibacterial activi
Externí odkaz:
https://doaj.org/article/bcbdb837da96405c82180f4578ebe063
Autor:
Inga Sileikaite-Morvaközi, William H. Hansen, Michael J. Davies, Thomas Mandrup-Poulsen, Clare L. Hawkins
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14585 (2023)
Neutrophils are innate immune cells that play a key role in pathogen clearance. They contribute to inflammatory diseases, including diabetes, by releasing pro-inflammatory cytokines, reactive oxygen species, and extracellular traps (NETs). NETs conta
Externí odkaz:
https://doaj.org/article/66667bcc3ef34fa2ac0c2d962ad87f9b
Autor:
Anniek F. Lubberding, Jinyi Zhang, Morten Lundh, Thomas Svava Nielsen, Mathilde S. Søndergaard, Maria Villadsen, Emil Z. Skovhøj, Geke A. Boer, Jakob B. Hansen, Morten B. Thomsen, Jonas T. Treebak, Jens J. Holst, Jørgen K. Kanters, Thomas Mandrup-Poulsen, Thomas Jespersen, Brice Emanuelli, Signe S. Torekov
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Loss-of-function (LoF) mutations in KCNQ1, encoding the voltage-gated K+ channel Kv7.1, lead to long QT syndrome 1 (LQT1). LQT1 patients also present with post-prandial hyperinsulinemia and hypoglycaemia. In contrast, KCNQ1 polymorphisms are
Externí odkaz:
https://doaj.org/article/bdb0c435470a478696e2cc00273a4925
Autor:
Laura Casares, Rita Moreno, Kevin X. Ali, Maureen Higgins, Sharadha Dayalan Naidu, Graham Neill, Lena Cassin, Anders E. Kiib, Esben B. Svenningsen, Alberto Minassi, Tadashi Honda, Thomas B. Poulsen, Clotilde Wiel, Volkan I. Sayin, Albena T. Dinkova-Kostova, David Olagnier, Laureano de la Vega
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102291- (2022)
The transcription factor BACH1 is a potential therapeutic target for a variety of chronic conditions linked to oxidative stress and inflammation, as well as cancer metastasis. However, only a few BACH1 degraders/inhibitors have been described. BACH1
Externí odkaz:
https://doaj.org/article/1416ed819aa4406aaf232a9276b3919d
Autor:
Carolin Hoefner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore Dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzynska, Kristian Klindt, Justyna Klusek, Marcelo J. Perone, Robert Bucki, Per Mårten Hägglund, Pontus Emanuel Gourdon, Kamil Gotfryd, Edyta Urbaniak, Malgorzata Borowiak, Michael Wierer, Patrick Edward MacDonald, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 152 (2023)
Apart from chaperoning, disulfide bond formation, and downstream processing, the molecular sequence of proinsulin folding is not completely understood. Proinsulin requires proline isomerization for correct folding. Since FK506-binding protein 2 (FKBP
Externí odkaz:
https://doaj.org/article/20ad96ddb7074192b89914e9a51cc41b