Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Thomas A. Packard"'
Autor:
Thomas A. Packard, Roland Schwarzer, Eytan Herzig, Deepashri Rao, Xiaoyu Luo, Johanne H. Egedal, Feng Hsiao, Marek Widera, Judd F. Hultquist, Zachary W. Grimmett, Ronald J. Messer, Nevan J. Krogan, Steven G. Deeks, Nadia R. Roan, Ulf Dittmer, Kim J. Hasenkrug, Warner C. Greene
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT HIV infects long-lived CD4 memory T cells, establishing a latent viral reservoir that necessitates lifelong antiretroviral therapy (ART). How this reservoir is formed so quickly after infection remains unclear. We now show the innate inflamm
Externí odkaz:
https://doaj.org/article/0c31ebd503514659ba779d1be8395425
Autor:
Jesper G. Pedersen, Johanne H. Egedal, Thomas A. Packard, Karthiga Thavachelvam, Guorui Xie, Renée Marije van der Sluis, Warner C. Greene, Nadia R. Roan, Martin R. Jakobsen
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The chemokine receptor CCR5 is expressed on multiple cell types, including macrophages, dendritic cells, and T cells, and is the major co-receptor used during HIV transmission. Using a standard αCD3/CD28 in vitro stimulation protocol to render CD4+
Externí odkaz:
https://doaj.org/article/645cdc5c0c3440dcb09dfb4688ca1a1b
Autor:
Thomas A. Packard, Mia J. Smith, Francis J. Conrad, Sara A. Johnson, Andrew Getahun, Robin S. Lindsay, Rochelle M. Hinman, Rachel S. Friedman, James W. Thomas, John C. Cambier
Publikováno v:
Journal of Clinical Medicine, Vol 5, Iss 11, p 98 (2016)
B cells have been strongly implicated in the development of human type 1 diabetes and are required for disease in the NOD mouse model. These functions are dependent on B cell antigen receptor (BCR) specificity and expression of MHC, implicating linke
Externí odkaz:
https://doaj.org/article/87f56d71e8ec483ca38f8e5c414a3970
Autor:
Martin R Jakobsen, Warner C. Greene, Guorui Xie, Anders Laustsen, Jason Neidleman, Satish K. Pillai, Johanne H Egedal, Thomas A. Packard, Nadia R. Roan, Konstantinos Georgiou
Publikováno v:
Mucosal immunology, vol 14, iss 5
Egedal, J H, Xie, G, Packard, T A, Laustsen, A, Neidleman, J, Georgiou, K, Pillai, S K, Greene, W C, Jakobsen, M R & Roan, N R 2021, ' Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection ', Mucosal Immunology, vol. 14, no. 5, pp. 1203-1213 . https://doi.org/10.1038/s41385-021-00409-3
Mucosal Immunology
Egedal, J H, Xie, G, Packard, T A, Laustsen, A, Neidleman, J, Georgiou, K, Pillai, S K, Greene, W C, Jakobsen, M R & Roan, N R 2021, ' Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection ', Mucosal Immunology, vol. 14, no. 5, pp. 1203-1213 . https://doi.org/10.1038/s41385-021-00409-3
Mucosal Immunology
The majority of HIV infections are established through the genital or rectal mucosa. Fibroblasts are abundant in these tissues, and although not susceptible to infection, can potently enhance HIV infection of CD4+ T cells. Hyaluronic acid (HA) is a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73953fb13cd9e0152e4d4bbab72b84df
https://escholarship.org/uc/item/1c4954vc
https://escholarship.org/uc/item/1c4954vc
Autor:
Juraj Adamik, Gilad Doitsh, Warner C. Greene, Deborah L. Galson, Nicole L. K. Galloway, Sree H Pulugulla, Philip E. Auron, Thomas A. Packard, Zachary W. Grimmett
Publikováno v:
Cytokine. 111:373-381
Interleukin 1β is a pro-inflammatory cytokine important for both normal immune responses and chronic inflammatory diseases. The regulation of the 31 kDa proIL-1β precursor coded by the IL1B gene has been extensively studied in myeloid cells, but no
Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo
Autor:
Emilie Besnard, Timothy J. Henrich, Warner C. Greene, Melanie Ott, Jacob D. Estes, William Brantley, Danielle M. Rosenthal, Nevan J. Krogan, Benjamin Varco-Merth, Michael Snape, Satish K. Pillai, Zachary W. Grimmett, Jeffrey D. Lifson, Hannah S. Sperber, Steven G. Deeks, Louise E. Hogan, Louis J. Picker, Michael Nekorchuk, Mark Connors, Stephen A. Migueles, Roland Schwarzer, Bernard Kiernan, Feng Hsiao, Thomas A. Packard, Jeffrey R. Johnson, Philip A. Hull, Nadia R. Roan, Mauricio Montano, Afam A. Okoye, Andrea Gramatica, Eytan Herzig, Eric Verdin
Publikováno v:
Journal of Virology. 95
An ability to activate latent HIV-1 expression could benefit many HIV cure strategies, but the first generation of latency reversing agents (LRAs) has proven disappointing. We evaluated AKT/mTOR activators as a potential new class of LRAs. Two glycog
Autor:
David J. Smith, James E. Fittje, Steven L. McCarty, Jason Hartwig, Paul C. Schmitz, Thomas F. O'Brien, John P. Gyekenyesi, Robert G. Jones, Elizabeth Turnbull, Geoffrey A. Landis, Anthony J. Colozza, Thomas W. Packard, Brent Faller, Phillip Abel, Noam R. Izenberg, Miles McKaig, Steven R. Oleson, Nicholas Lantz, Michael J. Bur
Publikováno v:
Bulletin of the AAS. 53
Autor:
Zachary W. Grimmett, Xiaoyu Luo, Eytan Herzig, Warner C. Greene, Schwarzer R, Marek Widera, Nevan J. Krogan, Steve Deeks, Hsiao F, Kim J. Hasenkrug, Ulf Dittmer, Judd F. Hultquist, Egedal Jh, Nadia R. Roan, Thomas A. Packard, Deepashri Rao, Ronald J. Messer
HIV infects long-lived CD4 memory T cells establishing a latent viral reservoir that necessitates lifelong anti-retroviral therapy (ART). How this reservoir is formed so swiftly remains unknown. We now show the innate inflammatory response to HIV inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19c2d7c62595ae388990115273308dbd
https://doi.org/10.1101/2021.02.25.432826
https://doi.org/10.1101/2021.02.25.432826
Autor:
Andrea, Gramatica, Roland, Schwarzer, William, Brantley, Benjamin, Varco-Merth, Hannah S, Sperber, Philip A, Hull, Mauricio, Montano, Stephen A, Migueles, Danielle, Rosenthal, Louise E, Hogan, Jeffrey R, Johnson, Thomas A, Packard, Zachary W, Grimmett, Eytan, Herzig, Emilie, Besnard, Michael, Nekorchuk, Feng, Hsiao, Steven G, Deeks, Michael, Snape, Bernard, Kiernan, Nadia R, Roan, Jeffrey D, Lifson, Jacob D, Estes, Louis J, Picker, Eric, Verdin, Nevan J, Krogan, Timothy J, Henrich, Mark, Connors, Melanie, Ott, Satish K, Pillai, Afam A, Okoye, Warner C, Greene
Publikováno v:
J Virol
An ability to activate latent human immunodeficiency virus type 1 (HIV-1) expression could benefit many HIV cure strategies; however, most latency-reversing agents (LRAs) have proven disappointing. We evaluated AKT/mTOR activators as a potential new
Autor:
Steven R. Oleson, Thomas W. Packard, David Grantier, Paul C. Schmitz, James E. Fittje, John P. Gyekenyesi, Mike Martini, John Dankanich, Anthony J. Colozza, Glenn L. Williams, Joe Warner
Publikováno v:
AIAA Propulsion and Energy 2019 Forum.
Recently, the New Horizons spacecraft flew by the Kuiper Belt Object Ultima Thule 13 years after launch. While flybys are a necessary 'first look' at the object in question a more comprehensive evaluation of the object will require an orbiter. Due to