Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Thomas A. Longden"'
Autor:
Xin Rui Lim, Mohammad M. Abd-Alhaseeb, Michael Ippolito, Masayo Koide, Amanda J. Senatore, Curtis Plante, Ashwini Hariharan, Nick Weir, Thomas A. Longden, Kathryn A. Laprade, James M. Stafford, Dorothea Ziemens, Markus Schwaninger, Jan Wenzel, Dmitry D. Postnov, Osama F. Harraz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Hyperemia in response to neural activity is essential for brain health. A hyperemic response delivers O2 and nutrients, clears metabolic waste, and concomitantly exposes cerebrovascular endothelial cells to hemodynamic forces. While neurovas
Externí odkaz:
https://doaj.org/article/e1f0cdd225cb4b8b8a10b16f5e16f028
Autor:
Amanda C. Rosehart, Thomas A. Longden, Nick Weir, Jackson T. Fontaine, Anne Joutel, Fabrice Dabertrand
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Prostaglandin E2 (PGE2) has been widely proposed to mediate neurovascular coupling by dilating brain parenchymal arterioles through activation of prostanoid EP4 receptors. However, our previous report that direct application of PGE2 induces an EP1-me
Externí odkaz:
https://doaj.org/article/4148c876ef004e72b07e88517823cb5b
Autor:
Ashwini Hariharan, Nick Weir, Colin Robertson, Liqun He, Christer Betsholtz, Thomas A. Longden
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Brain pericytes reside on the abluminal surface of capillaries, and their processes cover ~90% of the length of the capillary bed. These cells were first described almost 150 years ago (Eberth, 1871; Rouget, 1873) and have been the subject of intense
Externí odkaz:
https://doaj.org/article/2ab203d86e444377936d22e4d9e20295
Publikováno v:
Annual Review of Physiology. 85:137-164
Pericytes, attached to the surface of capillaries, play an important role in regulating local blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with confocal and multiphoton imaging techniques, the 3D structure, ana
Autor:
Colin M Cleary, Thiago S Moreira, Ana C Takakura, Mark T Nelson, Thomas A Longden, Daniel K Mulkey
Publikováno v:
eLife, Vol 9 (2020)
Respiratory chemoreceptors regulate breathing in response to changes in tissue CO2/H+. Blood flow is a fundamental determinant of tissue CO2/H+, yet little is known regarding how regulation of vascular tone in chemoreceptor regions contributes to res
Externí odkaz:
https://doaj.org/article/9ff7d9f1713040c0874ea849ac4d4a7e
Publikováno v:
eLife, Vol 7 (2018)
We recently reported that the inward-rectifier Kir2.1 channel in brain capillary endothelial cells (cECs) plays a major role in neurovascular coupling (NVC) by mediating a neuronal activity-dependent, propagating vasodilatory (hyperpolarizing) signal
Externí odkaz:
https://doaj.org/article/36a3959b2839416b96d944daee300602
Publikováno v:
Cell reports. 41(13)
Despite the abundance of capillary thin-strand pericytes and their proximity to neurons and glia, little is known of the contributions of these cells to the control of brain hemodynamics. We demonstrate that the pharmacological activation of thin-str
SUMMARYCapillary pericytes and their processes cover ∼90% of the total length of the brains capillary bed. Despite their abundance, little is known of pericyte function, and their contributions to the control of brain hemodynamics remain unclear. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ad51738f27ea3739a297276631ddc8b
https://doi.org/10.1101/2022.03.14.484304
https://doi.org/10.1101/2022.03.14.484304
Autor:
Thomas A Longden, Warren Lockette, Sheila Russell, Maria Sancho, Mark T. Nelson, Kalev Freeman, Amreen Mughal, Adrian M. Sackheim
Publikováno v:
J Cereb Blood Flow Metab
Traumatic brain injury (TBI) acutely impairs dynamic regulation of local cerebral blood flow, but long-term (>72 h) effects on functional hyperemia are unknown. Functional hyperemia depends on capillary endothelial cell inward rectifier potassium cha
Autor:
Mark T. Nelson, Bo Shui, Thomas A Longden, Amreen Mughal, Frank K. Lee, Jane C. Lee, Michael I. Kotlikoff, Gabriele M. König, David C. Hill-Eubanks, Shaun Reining, Evi Kostenis, Osama F. Harraz, Grant W. Hennig
Publikováno v:
Science Advances
Sci Adv
Sci Adv
Brain capillary calcium signaling controls blood flow.
Healthy brain function depends on the finely tuned spatial and temporal delivery of blood-borne nutrients to active neurons via the vast, dense capillary network. Here, using in vivo imaging
Healthy brain function depends on the finely tuned spatial and temporal delivery of blood-borne nutrients to active neurons via the vast, dense capillary network. Here, using in vivo imaging