Zobrazeno 1 - 10
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pro vyhledávání: '"Thomas A. Lallas"'
Autor:
Thomas A. Lallas, Richard E. Buller, John P. Geisler, Melanie A. Hatterman-Zogg, J.A. Rathe, Patricia A. Kirby
Publikováno v:
Human Mutation. 18:337-344
Recent studies have shown that the BRCA1 tumor suppressor gene plays a role in the development of both hereditary and sporadic ovarian cancer. Since several different mechanisms may give rise to tumor gene defects, a better understanding of these mec
Publikováno v:
Gynecologic Oncology. 76:418-422
Objective. X-Chromosome loss of heterozygosity (LOH) occurs in approximately 40% of ovarian cancers. We have previously demonstrated an association between nonrandom X-chromosome inactivation and germline BRCA1 mutation. The current study examines th
Publikováno v:
JNCI Journal of the National Cancer Institute. 91:339-346
Background: Most human female cells contain two X chromosomes, only one of which is active. The process of Xchromosome inactivation, which occurs early in development, is usually random, producing tissues with equal mixtures of cells having active X
Autor:
Philip C. Mehaffey, Bradley J. Van Voorhis, Thomas A. Lallas, Joel I. Sorosky, Donna J. Lager
Publikováno v:
Gynecologic Oncology. 72:238-242
Background. Primary malignant cervical schwannomas (malignant peripheral nerve sheath tumors) are extremely rare tumors that grossly may resemble many other more common lesions. The diagnosis, management, and follow-up of a malignant cervical schwann
Autor:
Scot A. Potts, Joel I. Sorosky, Thomas A. Lallas, Elisabeth M. Groginsky, Thomas E. Buekers, John K. Olson
Publikováno v:
Journal of Lower Genital Tract Disease. 3:67-70
j Abstract: Objective. Our aim was to report a fatal complication of hidradenitis suppurativa and a review of the literature. Materials and Methods. A case of severe hidradenitis suppurativa obscuring the diagnosis and precluding the treatment of a r
Publikováno v:
Journal of Gynecologic Surgery. 15:55-59
Primary ovarian leiomyomas are uncommon benign tumors that are usually asymptomatic. Distinguishing them from other ovarian tumors is important in order to render the appropriate prognosis...
Autor:
Thomas A. Lallas, Thomas E. Buekers
Publikováno v:
Obstetrics and Gynecology Clinics of North America. 25:323-329
There is limited information concerning the effects of chemotherapy administered during pregnancy, which consists mostly of case reports and small series. The National Cancer Institute maintains a registry of neonates exposed to chemotherapy but ther
Autor:
Joel I. Sorosky, Robert Dreicer, Jacqueline K. Joyce, Barrie Anderson, Richard E. Buller, Thomas A. Lallas
Publikováno v:
American Journal of Clinical Oncology. 21:287-290
The authors performed a phase II trial of the VIG regimen (vinblastine, ifosfamide, and gallium nitrate) in patients who had advanced ovarian cancer who were refractory to cisplatin and/or carboplatin and whose disease had progressed after paclitaxel
Publikováno v:
Molecular genetics and metabolism. 67(4)
BRCA1 mutation research in ovarian and breast cancer 17q21-linked families has yielded a large number of germline sequence variations. Somatic mutations have been uncommonly reported. We screened 81 probands with primary ovarian, peritoneal, or fallo
Autor:
Richard E. Buller, Thomas A. Lallas
Publikováno v:
Molecular genetics and metabolism. 64(3)
Single-strand confirmation polymorphism (SSCP) analysis on MDE gels has been extensively used to detect BRCA1 gene mutations. In screening a large cohort of ovarian cancer patients, our group was not completely satisfied with the standard published t