Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Thomas A. Keating"'
Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping
Autor:
Eshita Khera, Cornelius Cilliers, Michael D. Smith, Michelle L. Ganno, Katharine C. Lai, Thomas A. Keating, Anna Kopp, Ian Nessler, Adnan O. Abu-Yousif, Greg M. Thurber
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely
Externí odkaz:
https://doaj.org/article/a1d49a829b1446a5941d3e371fc652ef
Autor:
Joe Gerlach, Didier Debaise, Aline Wiame, Tom Roberts, Andrew Lapworth, J. D Dewsbury, Claire Colebrook, Nina Williams, Thomas P. Keating
Publikováno v:
Subjectivity. 30:91-106
Autor:
O. Petter Veiby, Jennifer Fretland, Mark G. Qian, Jayaprakasam Bolleddula, Robbie Robertson, Maria Borland, Melissa Saylor Landen, Cindy Q. Xia, Andy Zhu, Secil Koseoglu, Kurt Eng, Afrand Kamali, Bradley Stringer, Thomas A. Keating, Katharine C. Lai, Michael D. Smith, Michelle L. Ganno, Bret M. Bannerman, Melissa Gallery, Donna Cvet, Adnan O. Abu-Yousif
Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7d56b0bf0e605a39ee70fc897c8b59
https://doi.org/10.1158/1535-7163.c.6542328.v1
https://doi.org/10.1158/1535-7163.c.6542328.v1
Autor:
Greg M. Thurber, Richard Gregory, Jan Pinkas, Ravi Chari, Thomas A. Keating, Michael L. Miller, Yulius Setiady, Bahar Matin, Neeraj Kohli, Christopher Espelin, Olga Ab, Rassol Laleau, Eshita Khera, Leanne Lanieri, Jose F. Ponte
Supplementary figures and data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633ee436ae1eb2f1537f2ada328961b9
https://doi.org/10.1158/1535-7163.22521463
https://doi.org/10.1158/1535-7163.22521463
Autor:
Ravi V.J. Chari, Thomas A. Keating, Jan Pinkas, Olga Ab, Katharine C. Lai, Yelena Kovtun, Nicholas C. Yoder, Jose F. Ponte, Rajeeva Singh, Luke Harris, Dilrukshi Vitharana, Chen Bai, Katie E. Archer, Qifeng Qiu, Lauren Harvey, Erin K. Maloney, Surina Sikka, Leanne Lanieri, Emily E. Reid, Paulin Salomon, Alan Wilhelm, Manami Shizuka, Michael L. Miller
Tumor-selective delivery of cytotoxic agents in the form of antibody–drug conjugates (ADCs) is now a clinically validated approach for cancer treatment. In an attempt to improve the clinical success rate of ADCs, emphasis has been recently placed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d1e99e32e1b6463933f4f9a2e6edc1f
https://doi.org/10.1158/1535-7163.c.6537900.v1
https://doi.org/10.1158/1535-7163.c.6537900.v1
Autor:
Ravi V.J. Chari, Thomas A. Keating, Jan Pinkas, Olga Ab, Katharine C. Lai, Yelena Kovtun, Nicholas C. Yoder, Jose F. Ponte, Rajeeva Singh, Luke Harris, Dilrukshi Vitharana, Chen Bai, Katie E. Archer, Qifeng Qiu, Lauren Harvey, Erin K. Maloney, Surina Sikka, Leanne Lanieri, Emily E. Reid, Paulin Salomon, Alan Wilhelm, Manami Shizuka, Michael L. Miller
Figure S1. Structural representations and scheme for preparation of IGN ADCs. Figure S2A. In vitro potency comparing ADCs of an IGN DNA cross-linker and DNA alkylator. Figure S2B. In vitro potency comparing ADCs of an IGN DNA cross-linker and DNA alk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f568423d203af13cedff0663cdc34a8
https://doi.org/10.1158/1535-7163.22504929.v1
https://doi.org/10.1158/1535-7163.22504929.v1
Autor:
Ravi V.J. Chari, Thomas A. Keating, Jan Pinkas, Olga Ab, Katharine C. Lai, Yelena Kovtun, Nicholas C. Yoder, Jose F. Ponte, Rajeeva Singh, Luke Harris, Dilrukshi Vitharana, Chen Bai, Katie E. Archer, Qifeng Qiu, Lauren Harvey, Erin K. Maloney, Surina Sikka, Leanne Lanieri, Emily E. Reid, Paulin Salomon, Alan Wilhelm, Manami Shizuka, Michael L. Miller
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6fcae1da3f382759fcd9ae562eb2f6
https://doi.org/10.1158/1535-7163.22504926.v1
https://doi.org/10.1158/1535-7163.22504926.v1
Autor:
O. Petter Veiby, Jennifer Fretland, Mark G. Qian, Jayaprakasam Bolleddula, Robbie Robertson, Maria Borland, Melissa Saylor Landen, Cindy Q. Xia, Andy Zhu, Secil Koseoglu, Kurt Eng, Afrand Kamali, Bradley Stringer, Thomas A. Keating, Katharine C. Lai, Michael D. Smith, Michelle L. Ganno, Bret M. Bannerman, Melissa Gallery, Donna Cvet, Adnan O. Abu-Yousif
Supplemental Figure 1: heavy and light chain sequences for 5F9, the human IgG1 monoclonal antibody (mAb) targeting the extracellular domain of GCC as described previously Supplemental Figure 2: Characterization of TAK-164 and chKTI-DGN549 by A) SDS P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc671e1a3ed72f6591ec22f46838181
https://doi.org/10.1158/1535-7163.22519161.v1
https://doi.org/10.1158/1535-7163.22519161.v1
Autor:
Greg M. Thurber, Normann Goodwin, Lorraine Thompson, James Legg, Thomas Sandal, Adnan O. Abu-Yousif, Thomas A. Keating, Qifeng Qiu, Anna Kopp, Steven Vance, Eshita Khera, Ian Nessler
Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by concentrating drugs at the site-of-action, a method embodied by the seven current FDA-approved antibody–drug conjugates (ADC). However, a variety of pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bb7ab2805dd13cdbb4ee95f79492b5
https://doi.org/10.1158/0008-5472.c.6511984.v1
https://doi.org/10.1158/0008-5472.c.6511984.v1
Autor:
Didier Debaise, Thomas P. Keating
Publikováno v:
Theory, culture & society, 0
In conversation with Didier Debaise, this piece thinks transversally across Nature as Event (2017a) and Speculative Empiricism (2017b) to explore some of the key stakes in his philosophy, namely: the relationship between the task of thinking a specul