Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Thomas A. J. McKinnon"'
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
The 2019 coronavirus disease (COVID-19) is the disease caused by SARS-CoV-2 infection. Although this infection has been shown to affect the respiratory system, a high incidence of thrombotic events has been observed in severe cases of COVID-19 and in
Autor:
Thomas A. J. McKinnon
Publikováno v:
Blood. 141:1102-1103
Autor:
Thomas A. J. McKinnon, Alfonso De Simone, Alain Chion, Michael Laffan, Golzar Mobayen, Harrison E R O'Brien, Yan Xu, X. Frank Zhang, Maximo Sanz-Hernandez, Susan Shapiro
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:358-369
Background Von Willebrand factor (VWF) contains a number of free thiols, the majority of which are located in its C-domains, and these have been shown to alter VWF function, However, the impact of free thiols on function following acute exposure of V
Autor:
Talat H. Malik, Maria Prendecki, Renos Keniyopoullos, Thomas A. J. McKinnon, Stephen P. McAdoo, Amrita Dhutia, Michael Laffan, Golzar Mobayen, Michelle Willicombe, Candice Clarke
Publikováno v:
Research and Practice in Thrombosis and Haemostasis
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 6, Pp n/a-n/a (2021)
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 6, Pp n/a-n/a (2021)
Background A major clinical feature of severe coronavirus diease 2019 (COVID‐19) is microvascular thrombosis linked to endothelial cell activation. Consistent with this, a number of studies have shown that patients with severe COVID‐19 have highl
Autor:
Dilan Athauda, Hadi Manji, Michael S. Zandi, Ross W. Paterson, Moira J. Spyer, Amanda J. Heslegrave, Hannah Cohen, Tom Solomon, Henrik Zetterberg, Vinojini Vivekanandam, Jonathan M. Schott, Benedict D Michael, Alexander Foulkes, Melanie Hart, Michael P. Lunn, Rachel Moll, Hans Rolf Jäger, Robert Simister, Laura A Benjamin, Catherine J. Mummery, Puja Mehta, Stephen Keddie, Judith Heaney, Thomas A. J. McKinnon, Michael Chou, Kaj Blennow, Francesco Carletti, Catherine F Houlihan, Anna M. Checkley, David J. Werring, Maria Efthymiou, Arvind Chandratheva, Eleni Nastouli, Rachel Brown, Oliver J. Ziff, Charis Pericleous
Publikováno v:
EClinicalMedicine
EClinicalMedicine, Vol 39, Iss, Pp 101070-(2021)
EClinicalMedicine, Vol 39, Iss, Pp 101070-(2021)
Background: A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear.
Autor:
Michael Laffan, Koval E. Smith, Koichi Sasaki, Jun Ishihara, Matthias P. Lutolf, Jeffrey A. Hubbell, Michael J. V. White, Yoji Tabata, Kazuto Fukunaga, Richard D. Starke, Thomas A. J. McKinnon, Ako Ishihara, Claire Peghaire, Anna M. Randi
Publikováno v:
Blood. 133:2559-2569
During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate
Autor:
Marco P. Monopoli, Sandra L. Haberichter, Alan B. Moran, Thomas A. J. McKinnon, Richard A. Gardner, Daniel I. R. Spencer, Judicael Fazavana, Jyotika Sharma, Jamie M. O’Sullivan, Soracha E. Ward, Alain Chion, James S. O’Donnell
Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we showed that MGL influences phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6c4cc6b366b91dd9071cc283fcf688
http://hdl.handle.net/10044/1/96696
http://hdl.handle.net/10044/1/96696
Autor:
Thomas A. J. McKinnon, Angela Doerr, Wolfram Ruf, Alexandra Mazharian, Yotis A. Senis, Anthony Valance Washington, Maria Schander, Denise Pedrosa
Publikováno v:
Blood. 138:1050-1050
Background Thrombus formation is a complex, dynamic and multistep process, based on two crucial steps: platelet adhesion and platelet aggregation that both involve the large multimeric plasma glycoprotein Von Willebrand Factor (VWF). VWF binding to t
Autor:
Thomas A. J. McKinnon
Publikováno v:
Blood
Conventional treatment of hemophilia A (HA) requires repetitive IV injection of coagulation factor VIII (FVIII). Subcutaneous administration of FVIII is inefficient because of binding to the extravascular matrix, in particular to phospholipids (PLs),
Autor:
P. Henne, Agata Anna Nowak, Karen Vanhoorelbeke, Michael Laffan, A. Doerr, H. E. R. O'Brien, Thomas A. J. McKinnon
Publikováno v:
Journal of Thrombosis and Haemostasis. 15:1155-1166
Essentials The impact of N-linked glycosylation on ADAMTS-13 function has not been fully explored. The activity of glycan modified ADAMTS-13 was investigated under static and shear stress conditions. Terminal sialic acid on the metalloprotease domain