Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Thomas A. Grigliatti"'
Autor:
Joanna M Lubieniecka, Femke Streijger, Jae H T Lee, Nikolay Stoynov, Jie Liu, Randy Mottus, Tom Pfeifer, Brian K Kwon, Jens R Coorssen, Leonard J Foster, Thomas A Grigliatti, Wolfram Tetzlaff
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19247 (2011)
One of the major challenges in management of spinal cord injury (SCI) is that the assessment of injury severity is often imprecise. Identification of reliable, easily quantifiable biomarkers that delineate the severity of the initial injury and that
Externí odkaz:
https://doaj.org/article/687319676d3c4283a1a7d76373018a33
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3864 (2008)
Eukaryotic chromosomes terminate in telomeres, complex nucleoprotein structures that are required for chromosome integrity that are implicated in cellular senescence and cancer. The chromatin at the telomere is unique with characteristics of both het
Externí odkaz:
https://doaj.org/article/1eaa39f529ca494baf0b6c382c1fe954
Autor:
András Szeitz, Onkar S. Bains, K. Wayne Riggs, Thomas A. Grigliatti, Gina E. Cragg, Joanna M. Lubieniecka, Ronald E. Reid
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 347:375-387
The role of metabolism in daunorubicin (DAUN)- and doxorubicin (DOX)-associated toxicity in cancer patients is dependent on whether the parent drugs or major metabolites, doxorubicinol (DOXol) and daunorubicinol (DAUNol), are the more toxic species.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785760c6fa94683ac0684b771fed392e
https://doi.org/10.1124/jpet.113.206805
https://doi.org/10.1124/jpet.113.206805
Autor:
Emma S. Tomlinson Guns, Thomas A. Grigliatti, Hans Adomat, Ronald E. Reid, K. Wayne Riggs, Martin E. Gleave, Joanna M. Lubieniecka, Onkar S. Bains
Publikováno v:
Journal of Chromatography B. 902:84-95
Androgens are key mediators of prostate development and function, a role that extends to the development of prostate diseases such as benign prostatic hyperplasia (BPH) and prostate cancer. In prostate, DHT is the major androgen and reduction and glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c83a9774c14113cc0032a369559cae7
https://doi.org/10.1016/j.jchromb.2012.06.031
https://doi.org/10.1016/j.jchromb.2012.06.031
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:533-545
Doxorubicin (DOX) and daunorubicin (DAUN) are effective anticancer drugs; however, considerable interpatient variability exists in their pharmacokinetics. This may be caused by altered metabolism by nonsynonymous single-nucleotide polymorphisms (ns-S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e6ceb43fbe4c8c90bb23f71decdacd
https://doi.org/10.1124/jpet.110.173179
https://doi.org/10.1124/jpet.110.173179
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:1032-1039
Aldo-keto reductase (AKR) 1C2 is a human, cytosolic enzyme that has an important role in the deactivation of the potent androgen dihydrotestosterone (DHT). AKR1C2 can regulate the extent and duration of activation of the androgen receptor by catalyzi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015d218a4df83717aa6c5210828ae194
https://doi.org/10.1124/jpet.109.150995
https://doi.org/10.1124/jpet.109.150995
Autor:
Tom A. Pfeifer, Peter J. K. Knight, Layne Harvey, Caixia Ma, Ronald E. Reid, Thomas A. Grigliatti
Publikováno v:
Pharmacogenetics. 13:107-118
Objective to determine if the agonist serotonin and antagonists loxapine and clozapine have an altered potency for four allelic variants (T25N, I197V, A447V, and H452Y) of the human 5HT2A receptor when compared to the wild-type allele. Methods The re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89aa0c4d7c0b126e661afd7aef6d8c0
https://doi.org/10.1097/00008571-200302000-00007
https://doi.org/10.1097/00008571-200302000-00007
Publikováno v:
Chromosome Research. 11:573-583
The E(var)63A P mutation of Drosophila melanogaster was isolated in a genetic screen for P-element induced enhancers of w m4 variegation. Remobilization of the P-element in E(var)63A P resulted in a loss of its ability to enhance position-effect vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee24e6f32086dbe1dc6a2000daf548b
https://doi.org/10.1023/a:1024900817776
https://doi.org/10.1023/a:1024900817776
Publikováno v:
Genetics. 151:1503-1516
Genomic imprinting is a phenomenon in which the expression of a gene or chromosomal region depends on the sex of the individual transmitting it. The term imprinting was first coined to describe parent-specific chromosome behavior in the dipteran inse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593fdb66bf773ee0dca8c35d15e66f0c
https://doi.org/10.1093/genetics/151.4.1503
https://doi.org/10.1093/genetics/151.4.1503
Autor:
J. H. Whalen, Thomas A. Grigliatti
Publikováno v:
Molecular and General Genetics MGG. 260:401-409
The nomad element was identified as a retrovirus-like transposon in Drosophila melanogaster. DNA sequence analysis showed that the nomad element contains three long ORFs that are similar to the gag, pol and env genes of retrovirus- and the copia-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56bad559304810ff0072f64028cf7a7
https://doi.org/10.1007/s004380050910
https://doi.org/10.1007/s004380050910