Výsledky vyhledávání - "Thomas A. Bell"

Akademický článek

Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease

Autor: Chao Zhang, Michael Rehman, Xin Tian, Steven Lim Cho Pei, Jianlei Gu, Thomas A. Bell, Ke Dong, Ming Shen Tham, Yiqiang Cai, Zemeng Wei, Felix Behrens, Anton M. Jetten, Hongyu Zhao, Monkol Lek, Stefan Somlo

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Mouse models of autosomal dominant polycystic kidney disease (ADPKD) show that intact primary cilia are required for cyst growth following the inactivation of polycystin-1. The signaling pathways underlying this process, termed cilia-depende

Externí odkaz: https://doaj.org/article/be382d3d7234491f9e63a463c7ab57e7

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Akademický článek

Antisense oligonucleotide–mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice

Autor: Thomas A. Bell, III, Mingxia Liu, Aaron J. Donner, Richard G. Lee, Adam E. Mullick, Rosanne M. Crooke

Publikováno v: Journal of Lipid Research, Vol 62, Iss , Pp 100101- (2021)

Supported by an abundance of experimental and genetic evidence, angiopoietin-like protein 3 (ANGPTL3) has emerged as a promising therapeutic target for cardiovascular disease. ANGPTL3 is primarily produced by the liver and is a potent modulator of pl

Externí odkaz: https://doaj.org/article/25f0db78d9844c69a009494ec3a93e7b

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Akademický článek

Antisense oligonucleotide inhibition of cholesteryl ester transfer protein enhances RCT in hyperlipidemic, CETP transgenic, LDLr-/- mice

Autor: Thomas A. Bell, III, Mark J. Graham, Richard G. Lee, Adam E. Mullick, Wuxia Fu, Dan Norris, Rosanne M. Crooke

Publikováno v: Journal of Lipid Research, Vol 54, Iss 10, Pp 2647-2657 (2013)

Due to their ability to promote positive effects across all of the lipoprotein classes, cholesteryl ester transfer protein (CETP) inhibitors are currently being developed as therapeutic agents for cardiovascular disease. In these studies, we compared

Externí odkaz: https://doaj.org/article/91560ce2ba4e4b979efada06a3199aa8

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Akademický článek

Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein

Autor: Richard G. Lee, Wuxia Fu, Mark J. Graham, Adam E. Mullick, Donna Sipe, Danielle Gattis, Thomas A. Bell, Sheri Booten, Rosanne M. Crooke

Publikováno v: Journal of Lipid Research, Vol 54, Iss 3, Pp 602-614 (2013)

Therapeutic agents that suppress apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) levels/activity are being developed in the clinic to benefit patients who are unable to reach target LDL-C levels with maximally tolerated lip

Externí odkaz: https://doaj.org/article/ae8e17393005423c93e3c18a9df44372

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Akademický článek

Antisense oligonucleotide reduction of apoB-ameliorated atherosclerosis in LDL receptor-deficient mice[S]

Autor: Adam E. Mullick, Wuxia Fu, Mark J. Graham, Richard G. Lee, Donna Witchell, Thomas A. Bell, Charles P. Whipple, Rosanne M. Crooke

Publikováno v: Journal of Lipid Research, Vol 52, Iss 5, Pp 885-896 (2011)

Chronic elevations of plasma apolipoprotein B (apoB) are strongly associated with cardiovascular disease. We have previously demonstrated that inhibition of hepatic apoB mRNA using antisense oligonucleotides (ASO) results in reductions of apoB, VLDL,

Externí odkaz: https://doaj.org/article/573400dba3be49648a19529239706e89

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Akademický článek

Monounsaturated fatty acyl-coenzyme A is predictive of atherosclerosis in human apoB-100 transgenic, LDLr−/− mice

Autor: Thomas A. Bell, III, Martha D. Wilson, Kelley Kathryn, Janet K. Sawyer, Lawrence L. Rudel

Publikováno v: Journal of Lipid Research, Vol 48, Iss 5, Pp 1122-1131 (2007)

ACAT2, the enzyme responsible for the formation of cholesteryl esters incorporated into apolipoprotein B-containing lipoproteins by the small intestine and liver, forms predominantly cholesteryl oleate from acyl-CoA and free cholesterol. The accumula

Externí odkaz: https://doaj.org/article/79c535070af644ee94277a1942d45d8f

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Non-volatile marine and non-refractory continental sources of particle-phase amine during the North Atlantic Aerosols and Marine Ecosystems Study (NAAMES)

Autor: Veronica Z. Berta, Lynn M. Russell, Derek J. Price, Chia-Li Chen, Alex K. Y. Lee, Patricia K. Quinn, Timothy S. Bates, Thomas G. Bell, Michael J. Behrenfeld

Publikováno v: Atmospheric Chemistry and Physics. 23:2765-2787

Amines were measured by aerosol mass spectrometry (AMS) and Fourier transform infrared (FTIR) spectroscopy during the North Atlantic Aerosols and Marine Ecosystems Study (NAAMES) cruises. Both AMS non-refractory (NR) amine ion fragments comprising th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fc9023c71b4c78de6b36d294ce1bb2
https://doi.org/10.5194/acp-23-2765-2023

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Akademický článek

Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics

Publikováno v: Cell Reports, Vol 18, Iss 3, Pp 791-803 (2017)

Investigation of human CNS disease and drug effects has been hampered by the lack of a system that enables single-cell analysis of live adult patient brain cells. We developed a culturing system, based on a papain-aided procedure, for resected adult

Externí odkaz: https://doaj.org/article/dfca0d124ee0410cac03e2216d6c2535

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