Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Thomas A. Jowitt"'
Autor:
Anna L. Gray, Richard Karlsson, Abigail R.E. Roberts, Amanda J.L. Ridley, Nabina Pun, Bakhtbilland Khan, Craig Lawless, Rafael Luís, Martyna Szpakowska, Andy Chevigné, Catherine E. Hughes, Laura Medina-Ruiz, Holly L. Birchenough, Iashia Z. Mulholland, Catherina L. Salanga, Edwin A. Yates, Jeremy E. Turnbull, Tracy M. Handel, Gerard J. Graham, Thomas A. Jowitt, Ingo Schiessl, Ralf P. Richter, Rebecca L. Miller, Douglas P. Dyer
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111930- (2023)
Summary: Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflammati
Externí odkaz:
https://doaj.org/article/a86b22d342b64eea907a81850c7c8b16
Autor:
Francesca Malvezzi, Christopher J. Stubbs, Thomas A. Jowitt, Ian L. Dale, Xieyang Guo, Jon P. DeGnore, Gianluca Degliesposti, J. Mark Skehel, Andrew J. Bannister, Mark S. McAlister
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Malvezzi et al. discuss the impact of BRD4 phosphorylation on the formation of dimers and identify the key residues necessary for this dimerization. They also discuss the differential role of monovalent and bivalents bromodomain inhibitors regarding
Externí odkaz:
https://doaj.org/article/f5b48828673a41eebf428eec72402021
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Clark et al. comprehensively explore the primary structural features underlying the activity of a complete set of antimicrobial peptides (AMPs). They find that the shortest active peptides were 4 or 5 residues in length, with activity being associate
Externí odkaz:
https://doaj.org/article/07077bdf64fe48439afbfe1eab85d91f
Autor:
Paulina Fernández-Soto, Joshua Casulli, Danilo Solano-Castro, Pablo Rodríguez-Fernández, Thomas A. Jowitt, Mark A. Travis, Jennifer S. Cavet, Lydia Tabernero
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract SapM is a secreted virulence factor from Mycobacterium tuberculosis critical for pathogen survival and persistence inside the host. Its full potential as a target for tuberculosis treatment has not yet been exploited because of the lack of p
Externí odkaz:
https://doaj.org/article/5135dd571c544dfd9a33769cbc83fbac
Autor:
Yasmene F. Alanazi, Michael P. Lockhart-Cairns, Stuart A. Cain, Thomas A. Jowitt, Anthony S. Weiss, Clair Baldock
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Latent TGFβ binding protein-4 (LTBP4) is a multi-domain glycoprotein, essential for regulating the extracellular bioavailability of TGFβ and assembly of elastic fibre proteins, fibrillin-1 and tropoelastin. LTBP4 mutations are linked to autosomal r
Externí odkaz:
https://doaj.org/article/0d2bc83f21614a69a28db224a7269c76
Autor:
Allison J. Bancroft, Colin W. Levy, Thomas A. Jowitt, Kelly S. Hayes, Seona Thompson, Edward A. Mckenzie, Matthew D. Ball, Eamon Dubaissi, Aidan P. France, Bruno Bellina, Catherine Sharpe, Aleksandr Mironov, Sheila L. Brown, Peter C. Cook, Andrew S. MacDonald, David J. Thornton, Richard K. Grencis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm
Externí odkaz:
https://doaj.org/article/e790a9921fd644c2949b6cd1e5687605
Autor:
Deepankar Gahloth, Graham Heaven, Thomas A. Jowitt, A. Paul Mould, Jordi Bella, Clair Baldock, Philip Woodman, Lydia Tabernero
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract HD-PTP is a tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and cell migration. Central to its role is the specific recruitment of critical endosomal sorting complexes required for transport (E
Externí odkaz:
https://doaj.org/article/fb9b761d30ea4a3cbb093b0b72f678dd
Autor:
Maryline Fresquet, Thomas A. Jowitt, Edward A. McKenzie, Matthew D. Ball, Michael J. Randles, Rachel Lennon, Paul E. Brenchley
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Phospholipase A2 receptor (PLA2R) is a member of the mannose receptor family found in podocytes in human kidney. PLA2R is the target of the autoimmune disease, membranous nephropathy, characterised by production of anti-PLA2R autoantibodies
Externí odkaz:
https://doaj.org/article/2153c86a3e0c4f218eab15f2eb4b83f0
Autor:
Amanda JL Ridley, Yaqing Ou, Richard Karlsson, Nabina Pun, Holly L Birchenough, Thomas A Jowitt, Craig Lawless, Rebecca L Miller, Douglas P Dyer
Chemokine driven leukocyte recruitment is a key component of the immune response and is central to a wide range of diseases. However, there has yet to be a clinically successful therapeutic approach that targets the chemokine system during inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::245a772df5d8f80f5dcc92cbb0c64d4c
https://doi.org/10.1101/2022.09.20.508420
https://doi.org/10.1101/2022.09.20.508420
Autor:
Anna L Gray, Richard Karlsson, Abigail RE Roberts, Amanda JL Ridley, Nabina Pun, Catherine Hughes, Laura Medina-Ruiz, Holly L Birchenough, Catherina L Salanga, Edwin A Yates, Jeremy E Turnbull, Tracy M Handel, Gerard J Graham, Thomas A Jowitt, Ingo Schiessl, Ralf P Richter, Rebecca L Miller, Douglas P Dyer
Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system, but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflammation, due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc5fb4e6554a81b5b523e626b0e78da4
https://doi.org/10.1101/2022.07.10.499282
https://doi.org/10.1101/2022.07.10.499282