Výsledky vyhledávání - "Thomas A. Gasiewicz"

Impact of the Aryl Hydrocarbon Receptor on Aurora A Kinase and the G2/M Phase Pathway in Hematopoietic Stem and Progenitor Cells

Autor: Anthony M. Franchini, Keegan Vaughan, Soumyaroop Bhattacharya, Kameshwar Singh, Thomas A. Gasiewicz, B. Paige Lawrence

Publikováno v: Receptors
Volume 2
Issue 1
Pages: 100-115

Recent evidence suggests that the environment-sensing transcription factor aryl hydrocarbon receptor (AHR) is an important regulator of hematopoiesis. Yet, the mechanisms and extent of AHR-mediated regulation within the most primitive hematopoietic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043a68df8293e431bd6ec9715ef4cc57
https://doi.org/10.3390/receptors2010006

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Supplemental Methods, Figure 1, Tables 1A and B from The Heat Shock Protein 90 Inhibitor, (−)-Epigallocatechin Gallate, Has Anticancer Activity in a Novel Human Prostate Cancer Progression Model

Autor: Thomas A. Gasiewicz, William A. Ricke, Ellen C. Henry, Michael A. Moses

Supplemental Methods, Figure 1, Tables 1A and B. Supplemental Figure 1: Chaperone function assay; Supplemental Table 1A: Densitrometry analysis of HSP90-clients in response to EGCG; Supplemental Table 1B: Densitometry analysis of HSP90-clients in non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a439d327ddd032d2b29bf83be16f0d
https://doi.org/10.1158/1940-6207.22525821

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Data from The Heat Shock Protein 90 Inhibitor, (−)-Epigallocatechin Gallate, Has Anticancer Activity in a Novel Human Prostate Cancer Progression Model

Autor: Thomas A. Gasiewicz, William A. Ricke, Ellen C. Henry, Michael A. Moses

(−)-Epigallocatechin gallate (EGCG), a major tea polyphenol, elicits anticancer effects. However, the mechanism of action is not fully understood. Our laboratory previously showed that EGCG inhibits heat shock protein 90 (HSP90). We used nontumorig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10962aeea606c85148c349fcd2bfa196
https://doi.org/10.1158/1940-6207.c.6544923

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Akademický článek

Conditional deletion of Ahr alters gene expression profiles in hematopoietic stem cells.

Autor: John A Bennett, Kameshwar P Singh, Stephen L Welle, Lisbeth A Boule, B Paige Lawrence, Thomas A Gasiewicz

Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0206407 (2018)

The aryl hydrocarbon receptor (AHR) is a ligand activated bHLH transcription factor that belongs to the Per-Arnt-Sim (PAS) superfamily of proteins involved in mediating responses to cellular environment regulating normal physiological and development

Externí odkaz: https://doaj.org/article/beba980c23124282a5c3cf8304d12817

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Akademický článek

Aryl Hydrocarbon Receptor and Stem Cells

Autor: Thomas A. Gasiewicz, Kameshwar P. Singh, Fanny L. Casado

Publikováno v: Stem Cells International, Vol 2017 (2017)

Externí odkaz: https://doaj.org/article/2ebd51aef0704222b14505048972b7d1

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Akademický článek

Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells

Autor: Zeenath Unnisa, Kameshwar P. Singh, Ellen C. Henry, Catherine L. Donegan, John A. Bennett, Thomas A. Gasiewicz

Publikováno v: Stem Cells International, Vol 2016 (2016)

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor belonging to the Per-Arnt-Sim (PAS) family of proteins. The AHR is involved in hematopoietic stem cell (HSC) functions including self-renewal, proliferation, quiescence, a

Externí odkaz: https://doaj.org/article/a400f50bcad84510bcf0f6a7f497bd02

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Akademický článek

Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells.

Autor: John A Bennett, Kameshwar P Singh, Zeenath Unnisa, Stephen L Welle, Thomas A Gasiewicz

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0133791 (2015)

Dysregulation of hematopoietic stem cell (HSC) signaling can contribute to the development of diseases of the blood system. Lack of aryl hydrocarbon receptor (AhR) has been associated with alterations in gene expression related to HSC function and th

Externí odkaz: https://doaj.org/article/d8f953f0a9234cfe8fcc54624a81cd1a

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Akademický článek

Enhanced Detection of β-Galactosidase Reporter Activation Is Achieved by a Reduction of Hemoglobin Content in Tissue Lysates

Autor: Daniel A. Nazarenko, Stephen D. Dertinger, Thomas A. Gasiewicz

Publikováno v: BioTechniques, Vol 30, Iss 4, Pp 776-781 (2001)

β-galactosidase (β-gal), the product of the E. coli LacZ gene, has been used extensively as a reporter in numerous systems. Until recently, the most commonly used method of detecting β-gal reporter enzymatic activity was a colormetric assay based

Externí odkaz: https://doaj.org/article/61e7b0f7fae8496db001103cba1a974b

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