Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Thomas A Szabo-Pardi"'
Autor:
Shevon N. Alexander, Audrey R. Green, Emily K. Debner, Lindsey E. Ramos Freitas, Hanna M. K. Abdelhadi, Thomas A. Szabo-Pardi, Michael D. Burton
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract With the National Institutes of Health’s mandate to consider sex as a biological variable (SABV), there has been a significant increase of studies utilizing both sexes. Historically, we have known that biological sex and hormones influence
Externí odkaz:
https://doaj.org/article/fe6f313b62f842c7b5d65112df6b1719
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting side effect that occurs in up to 63% of patients and has no known effective treatment. A majority of studies do not effectively assess sex differences in the onset and persist
Externí odkaz:
https://doaj.org/article/a19a1e7f1c004208a6ec6d5839579696
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Peripheral nerve injury induces a myriad of immune-derived symptoms that negatively impacts pain, depression, and overall quality of life. Neuroimmune differences underlie sexual dimorphisms in various pain states. The innate immune system is a sourc
Externí odkaz:
https://doaj.org/article/b6f05a9ee2604dd187cee8ec26314331
Publikováno v:
Neurobiology of Pain, Vol 4, Iss , Pp 45-50 (2018)
Mitogen activated protein kinase-interacting kinase (MNK)-mediated phosphorylation of the mRNA cap binding protein eIF4E controls the translation of a subset of mRNAs that are involved in neuronal and immune plasticity. MNK-eIF4E signaling plays a cr
Externí odkaz:
https://doaj.org/article/288aa023dae64c36bd0a3dcaf710abd9
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 6, Pp 1202-1203 (2021)
Externí odkaz:
https://doaj.org/article/cb75296c8ff742fca784bbf7dfbb24ea
Publikováno v:
Molecular pain.
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder primarily diagnosed in women. Historically, clinical literature focusing on cytokines and immune cells has been inconsistent. However, recent key studies show several layers of immune syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3301984419bdcb351e9bdabf054d64c9
https://pubmed.ncbi.nlm.nih.gov/35712872
https://pubmed.ncbi.nlm.nih.gov/35712872
Publikováno v:
Neuropharmacology. 225
Pain sensitization is a phenomenon that occurs to protect tissues from damage and recent studies have shown how a variety of non-noxious stimuli included in our everyday lives can lead to pain sensitization. Consumption of large amounts of alcohol ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5470f5488141bafff4175065aa0a5fb
https://pubmed.ncbi.nlm.nih.gov/36460082
https://pubmed.ncbi.nlm.nih.gov/36460082
Autor:
Michael D. Burton, Eric D. Ramirez, Timothy A. McDougal, Grishma Pradhan, Gregory Dussor, Emma Wentworth, Thomas A. Szabo-Pardi, Kufreobong E. Inyang, Theodore J. Price
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
AMP-activated protein kinase (AMPK) is a multifunctional kinase that negatively regulates the mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) signaling, two signaling pathways linked to pain promotion after injury,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb4bfb5a28c0583f4067b2e96347420
https://doi.org/10.1124/jpet.119.258400
https://doi.org/10.1124/jpet.119.258400
Autor:
Timothy A. McDougal, Kufreobong E. Inyang, Thomas A. Szabo-Pardi, Emma Wentworth, Theodore J. Price, Michael D. Burton, Gregory Dussor
Publikováno v:
Pharmacological Research. 139:1-16
Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the drug has many mechanisms of action, most of these converge on AMP activated protein kinase (AMPK), which metformin activates. AMPK is a multifunctional kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57efdb6e89767f7212db6aa7634fc32a
https://doi.org/10.1016/j.phrs.2018.10.027
https://doi.org/10.1016/j.phrs.2018.10.027
Publikováno v:
Brain Behav Immun
Recent studies have brought to light the necessity to discern sex-specific differences in various pain states and different cell-types that mediate these differences. These studies have uncovered the role of neuroimmune interactions to mediate pain s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3012909fd840bff086aff055244af8
https://europepmc.org/articles/PMC8453057/
https://europepmc.org/articles/PMC8453057/
