Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thomas A Rawlinson"'
Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.
Autor:
Ellen Knuepfer, Katherine E Wright, Surendra Kumar Prajapati, Thomas A Rawlinson, Franziska Mohring, Marion Koch, Oliver R Lyth, Steven A Howell, Elizabeth Villasis, Ambrosius P Snijders, Robert W Moon, Simon J Draper, Anna Rosanas-Urgell, Matthew K Higgins, Jake Baum, Anthony A Holder
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007809 (2019)
Malaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric complex comprised of the secreted parasite proteins, PfCyRPA, PfRIPR and P
Externí odkaz:
https://doaj.org/article/bf3f93b27c2446d885488d06fde5f031
Autor:
Franziska Mohring, Melissa Natalie Hart, Thomas A Rawlinson, Ryan Henrici, James A Charleston, Ernest Diez Benavente, Avnish Patel, Joanna Hall, Neil Almond, Susana Campino, Taane G Clark, Colin J Sutherland, David A Baker, Simon J Draper, Robert William Moon
Publikováno v:
eLife, Vol 8 (2019)
Tackling relapsing Plasmodium vivax and zoonotic Plasmodium knowlesi infections is critical to reducing malaria incidence and mortality worldwide. Understanding the biology of these important and related parasites was previously constrained by the la
Externí odkaz:
https://doaj.org/article/1ca0a269871c490aa53c1d1b9ac0d2cc
Autor:
Florian A. Bach, Diana Muñoz Sandoval, Michalina Mazurczyk, Yrene Themistocleous, Thomas A. Rawlinson, Adam C. Harding, Alison Kemp, Sarah E. Silk, Jordan R. Barrett, Nick J. Edwards, Alasdair Ivens, Julian C. Rayner, Angela M. Minassian, Giorgio Napolitani, Simon J. Draper, Philip J. Spence
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
BACKGROUND The biology of Plasmodium vivax is markedly different from that of P. falciparum; how this shapes the immune response to infection remains unclear. To address this shortfall, we inoculated human volunteers with a clonal field isolate of P.
Externí odkaz:
https://doaj.org/article/d31b6e682890476cba7fb42065b54f54
Autor:
Jo Salkeld, Yrene Themistocleous, Jordan R. Barrett, Celia H. Mitton, Thomas A. Rawlinson, Ruth O. Payne, Mimi M. Hou, Baktash Khozoee, Nick J. Edwards, Carolyn M. Nielsen, Diana Muñoz Sandoval, Florian A. Bach, Wiebke Nahrendorf, Raquel Lopez Ramon, Megan Baker, Fernando Ramos-Lopez, Pedro M. Folegatti, Doris Quinkert, Katherine J. Ellis, Ian D. Poulton, Alison M. Lawrie, Jee-Sun Cho, Fay L. Nugent, Philip J. Spence, Sarah E. Silk, Simon J. Draper, Angela M. Minassian
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In endemic settings it is known that natural malaria immunity is gradually acquired following repeated exposures. Here we sought to assess whether similar acquisition of blood-stage malaria immunity would occur following repeated parasite exposure by
Externí odkaz:
https://doaj.org/article/e073d6a50a334532bed97edf79803bd5
Autor:
Angela M. Minassian, Yrene Themistocleous, Sarah E. Silk, Jordan R. Barrett, Alison Kemp, Doris Quinkert, Carolyn M. Nielsen, Nick J. Edwards, Thomas A. Rawlinson, Fernando Ramos Lopez, Wanlapa Roobsoong, Katherine J.D. Ellis, Jee-Sun Cho, Eerik Aunin, Thomas D. Otto, Adam J. Reid, Florian A. Bach, Geneviève M.C. Labbé, Ian D. Poulton, Arianna Marini, Marija Zaric, Margaux Mulatier, Raquel Lopez Ramon, Megan Baker, Celia H. Mitton, Jason C. Sousa, Nattawan Rachaphaew, Chalermpon Kumpitak, Nongnuj Maneechai, Chayanut Suansomjit, Tianrat Piteekan, Mimi M. Hou, Baktash Khozoee, Kirsty McHugh, David J. Roberts, Alison M. Lawrie, Andrew M. Blagborough, Fay L. Nugent, Iona J. Taylor, Kimberly J. Johnson, Philip J. Spence, Jetsumon Sattabongkot, Sumi Biswas, Julian C. Rayner, Simon J. Draper
Publikováno v:
JCI Insight, Vol 6, Iss 23 (2021)
Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-charac
Externí odkaz:
https://doaj.org/article/8f5efdb3fb3a46f088a6c09f41c0d102
Autor:
Mimi M. Hou, Jordan R. Barrett, Yrene Themistocleous, Thomas A. Rawlinson, Ababacar Diouf, Francisco J. Martinez, Carolyn M. Nielsen, Amelia M. Lias, Lloyd D. W. King, Nick J. Edwards, Nicola M. Greenwood, Lucy Kingham, Ian D. Poulton, Baktash Khozoee, Cyndi Goh, Dylan J. Mac Lochlainn, Jo Salkeld, Micheline Guilotte-Blisnick, Christèle Huon, Franziska Mohring, Jenny M. Reimer, Virander S. Chauhan, Paushali Mukherjee, Sumi Biswas, Iona J. Taylor, Alison M. Lawrie, Jee-Sun Cho, Fay L. Nugent, Carole A. Long, Robert W. Moon, Kazutoyo Miura, Sarah E. Silk, Chetan E. Chitnis, Angela M. Minassian, Simon J. Draper
BackgroundThere are no licensed vaccines against Plasmodium vivax, the most common cause of malaria outside of Africa.MethodsWe conducted two Phase I/IIa clinical trials to assess the safety, immunogenicity and efficacy of two vaccines targeting regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364b22e40ad1268e8e4f2556fbede97b
https://hal-pasteur.archives-ouvertes.fr/pasteur-04117002
https://hal-pasteur.archives-ouvertes.fr/pasteur-04117002
Autor:
Mimi M, Hou, Jordan R, Barrett, Yrene, Themistocleous, Thomas A, Rawlinson, Ababacar, Diouf, Francisco J, Martinez, Carolyn M, Nielsen, Amelia M, Lias, Lloyd D W, King, Nick J, Edwards, Nicola M, Greenwood, Lucy, Kingham, Ian D, Poulton, Baktash, Khozoee, Cyndi, Goh, Dylan J, Mac Lochlainn, Jo, Salkeld, Micheline, Guilotte-Blisnick, Christèle, Huon, Franziska, Mohring, Jenny M, Reimer, Virander S, Chauhan, Paushali, Mukherjee, Sumi, Biswas, Iona J, Taylor, Alison M, Lawrie, Jee-Sun, Cho, Fay L, Nugent, Carole A, Long, Robert W, Moon, Kazutoyo, Miura, Sarah E, Silk, Chetan E, Chitnis, Angela M, Minassian, Simon J, Draper
Publikováno v:
medRxiv : the preprint server for health sciences.
There are no licensed vaccines againstWe conducted two Phase I/IIa clinical trials to assess the safety, immunogenicity and efficacy of two vaccines targeting region II ofThirty-two volunteers were enrolled and vaccinated (n=16 for each vaccine). No
Autor:
Geneviève M. Labbé, Eerik Aunin, Yrene Themistocleous, Jee Sun Cho, Raquel Lopez Ramon, Julian C. Rayner, Baktash Khozoee, Chayanut Suansomjit, Sarah E. Silk, Doris Quinkert, Alison Kemp, Thomas D. Otto, Iona J. Taylor, Alison M. Lawrie, Simon J. Draper, Angela M. Minassian, Thomas A. Rawlinson, Marija Zaric, Celia Mitton, Jason C. Sousa, Jetsumon Sattabongkot, Andrew M. Blagborough, Sumi Biswas, Kimberly J. Johnson, Florian Bach, Chalermpon Kumpitak, Adam J. Reid, Margaux Mulatier, Nongnuj Maneechai, Ian D. Poulton, Katherine J. Ellis, Nattawan Rachaphaew, Nick J. Edwards, Fernando Ramos Lopez, Philip J Spence, Carolyn M. Nielsen, Wanlapa Roobsoong, Arianna Marini, Kirsty McHugh, Megan Baker, David J. Roberts, Mimi M. Hou, Tianrat Piteekan, Jordan R. Barrett, Fay L. Nugent
Publikováno v:
Minassian, A M, Themistocleous, Y, Silk, S E, Barrett, J R, Kemp, A, Quinkert, D, Nielsen, C M, Edwards, N J, Rawlinson, T A, Ramos Lopez, F, Roobsoong, W, Ellis, K J D, Cho, J-S, Aunin, E, Otto, T D, Reid, A J, Bach, F A, Labbé, G M C, Poulton, I D, Marini, A, Zaric, M, Mulatier, M, Lopez Ramon, R, Baker, M, Mitton, C H, Sousa, J C, Rachaphaew, N, Kumpitak, C, Maneechai, N, Suansomjit, C, Piteekan, T, Hou, M M, Khozoee, B, McHugh, K, Roberts, D J, Lawrie, A M, Blagborough, A M, Nugent, F L, Taylor, I J, Johnson, K J, Spence, P J, Sattabongkot, J, Biswas, S, Rayner, J C & Draper, S J 2021, ' Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly ', JCI Insight, vol. 6, no. 23, e152465 . https://doi.org/10.1172/jci.insight.152465
JCI Insight
JCI Insight
Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-charac
Autor:
Raquel Lopez Ramon, Chayanut Suansomjit, Fernando Ramos Lopez, Angela M. Minassian, Philip J Spence, Margaux Mulatier, Baktash Khozoee, Florian Bach, Carolyn M. Nielsen, Katherine J. Ellis, Chalermpon Kumpitak, Megan Baker, Jordan R. Barrett, Nattawan Rachaphaew, Sarah E. Silk, Kimberly J. Johnson, Ian D. Poulton, Doris Quinkert, Nick J. Edwards, Mimi M. Hou, Alison M. Lawrie, Yrene Themistocleous, Tianrat Piteekan, Simon J. Draper, Jee Sun Cho, Wanlapa Roobsoong, Adam J. Reid, Arianna Marini, Nongnuj Maneechai, Geneviève M. Labbé, Jetsumon Sattabongkot, Celia Mitton, Iona J. Taylor, Julian C. Rayner, Fay L. Nugent, Jason C. Sousa, Thomas D. Otto, David J. Roberts, Alison Kemp, Andrew M. Blagborough, Thomas A. Rawlinson, Marija Zaric, Sumi Biswas, Eerik Aunin
Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62f64e0fc59168d7bbe0cbbdc65a18c6
https://doi.org/10.1101/2021.07.23.21259839
https://doi.org/10.1101/2021.07.23.21259839
Autor:
Robert W. Moon, Geneviève M. Labbé, Franziska Mohring, Simon J. Draper, Sarah E. Silk, Jee Sun Cho, Natalie M. Barber, Doris Quinkert, François Nosten, Bruce Russell, Thomas A. Rawlinson, Jennifer M. Marshall, Samuel F. Gérard, Varakorn Kosaisavee, Laurent Rénia, Ruth O. Payne, Angela M. Minassian, Jing Jin, Daniel G. W. Alanine, Sean C. Elias, Matthew K. Higgins
Publikováno v:
Nature microbiology
Nature Microbiology
Nature Microbiology
Summary The most widespread form of malaria is caused by Plasmodium vivax. To replicate, this parasite must invade immature red blood cells, through a process which requires interaction of the Plasmodium vivax Duffy binding protein, PvDBP with its hu