Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research

Autor: Franziska Mohring, Melissa Natalie Hart, Thomas A Rawlinson, Ryan Henrici, James A Charleston, Ernest Diez Benavente, Avnish Patel, Joanna Hall, Neil Almond, Susana Campino, Taane G Clark, Colin J Sutherland, David A Baker, Simon J Draper, Robert William Moon

Publikováno v: eLife, Vol 8 (2019)

Tackling relapsing Plasmodium vivax and zoonotic Plasmodium knowlesi infections is critical to reducing malaria incidence and mortality worldwide. Understanding the biology of these important and related parasites was previously constrained by the la

Externí odkaz: https://doaj.org/article/1ca0a269871c490aa53c1d1b9ac0d2cc

A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection

Autor: Carola Schäfer, Wanlapa Roobsoong, Niwat Kangwanrangsan, Martino Bardelli, Thomas A. Rawlinson, Nicholas Dambrauskas, Olesya Trakhimets, Chaitra Parthiban, Debashree Goswami, Laura M. Reynolds, Spencer Y. Kennedy, Erika L. Flannery, Sean C. Murphy, D. Noah Sather, Simon J. Draper, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, Stefan H.I. Kappe

Publikováno v: iScience, Vol 23, Iss 8, Pp 101381- (2020)

Summary: The human malaria parasite Plasmodium vivax remains vastly understudied, mainly due to the lack of suitable laboratory models. Here, we report a humanized mouse model to test interventions that block P. vivax parasite transition from liver s

Externí odkaz: https://doaj.org/article/539baa8ec6b04adda354f129f8d342b9

Repeat controlled human malaria infection of healthy UK adults with blood-stage

Autor: Jo, Salkeld, Yrene, Themistocleous, Jordan R, Barrett, Celia H, Mitton, Thomas A, Rawlinson, Ruth O, Payne, Mimi M, Hou, Baktash, Khozoee, Nick J, Edwards, Carolyn M, Nielsen, Diana Muñoz, Sandoval, Florian A, Bach, Wiebke, Nahrendorf, Raquel Lopez, Ramon, Megan, Baker, Fernando, Ramos-Lopez, Pedro M, Folegatti, Doris, Quinkert, Katherine J, Ellis, Ian D, Poulton, Alison M, Lawrie, Jee-Sun, Cho, Fay L, Nugent, Philip J, Spence, Sarah E, Silk, Simon J, Draper, Angela M, Minassian

Publikováno v: Frontiers in immunology. 13

In endemic settings it is known that natural malaria immunity is gradually acquired following repeated exposures. Here we sought to assess whether similar acquisition of blood-stage malaria immunity would occur following repeated parasite exposure by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5875b0224b4a3cf7922be74ca4166e39
https://pubmed.ncbi.nlm.nih.gov/36072606

Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly

Autor: Geneviève M. Labbé, Eerik Aunin, Yrene Themistocleous, Jee Sun Cho, Raquel Lopez Ramon, Julian C. Rayner, Baktash Khozoee, Chayanut Suansomjit, Sarah E. Silk, Doris Quinkert, Alison Kemp, Thomas D. Otto, Iona J. Taylor, Alison M. Lawrie, Simon J. Draper, Angela M. Minassian, Thomas A. Rawlinson, Marija Zaric, Celia Mitton, Jason C. Sousa, Jetsumon Sattabongkot, Andrew M. Blagborough, Sumi Biswas, Kimberly J. Johnson, Florian Bach, Chalermpon Kumpitak, Adam J. Reid, Margaux Mulatier, Nongnuj Maneechai, Ian D. Poulton, Katherine J. Ellis, Nattawan Rachaphaew, Nick J. Edwards, Fernando Ramos Lopez, Philip J Spence, Carolyn M. Nielsen, Wanlapa Roobsoong, Arianna Marini, Kirsty McHugh, Megan Baker, David J. Roberts, Mimi M. Hou, Tianrat Piteekan, Jordan R. Barrett, Fay L. Nugent

Publikováno v: Minassian, A M, Themistocleous, Y, Silk, S E, Barrett, J R, Kemp, A, Quinkert, D, Nielsen, C M, Edwards, N J, Rawlinson, T A, Ramos Lopez, F, Roobsoong, W, Ellis, K J D, Cho, J-S, Aunin, E, Otto, T D, Reid, A J, Bach, F A, Labbé, G M C, Poulton, I D, Marini, A, Zaric, M, Mulatier, M, Lopez Ramon, R, Baker, M, Mitton, C H, Sousa, J C, Rachaphaew, N, Kumpitak, C, Maneechai, N, Suansomjit, C, Piteekan, T, Hou, M M, Khozoee, B, McHugh, K, Roberts, D J, Lawrie, A M, Blagborough, A M, Nugent, F L, Taylor, I J, Johnson, K J, Spence, P J, Sattabongkot, J, Biswas, S, Rayner, J C & Draper, S J 2021, ' Controlled human malaria infection with a clone of Plasmodium vivax with high-quality genome assembly ', JCI Insight, vol. 6, no. 23, e152465 . https://doi.org/10.1172/jci.insight.152465
JCI Insight

Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc190240819a778fd98762e57e377c28
https://doi.org/10.1172/jci.insight.152465

Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralising vaccine-induced human antibody

Autor: Robert W. Moon, Geneviève M. Labbé, Franziska Mohring, Simon J. Draper, Sarah E. Silk, Jee Sun Cho, Natalie M. Barber, Doris Quinkert, François Nosten, Bruce Russell, Thomas A. Rawlinson, Jennifer M. Marshall, Samuel F. Gérard, Varakorn Kosaisavee, Laurent Rénia, Ruth O. Payne, Angela M. Minassian, Jing Jin, Daniel G. W. Alanine, Sean C. Elias, Matthew K. Higgins

Publikováno v: Nature microbiology
Nature Microbiology

Summary The most widespread form of malaria is caused by Plasmodium vivax. To replicate, this parasite must invade immature red blood cells, through a process which requires interaction of the Plasmodium vivax Duffy binding protein, PvDBP with its hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4696ef8ed6e0b8376c7a4efc5d707750
http://europepmc.org/articles/PMC6711757