Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Thomas A Engler"'
Autor:
Jennifer M Atkinson, Kenneth B Rank, Yi Zeng, Andrew Capen, Vipin Yadav, Jason R Manro, Thomas A Engler, Marcio Chedid
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125028 (2015)
It has previously been observed that a loss of β-catenin expression occurs with melanoma progression and that nuclear β-catenin levels are inversely proportional to cellular proliferation, suggesting that activation of the Wnt/β-catenin pathway ma
Externí odkaz:
https://doaj.org/article/1800f53a19f846dd955aa441443164bd
Autor:
Louis F. Stancato, Thomas A. Engler, Michele Dowless, Wayne Blosser, Jonathan Low, Jeffrey J. Sutherland
Supplementary Material from A Robust High-Content Imaging Approach for Probing the Mechanism of Action and Phenotypic Outcomes of Cell-Cycle Modulators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428c03d678ddd8036b7d2fe95f6a5e75
https://doi.org/10.1158/1535-7163.22496806.v1
https://doi.org/10.1158/1535-7163.22496806.v1
Autor:
Louis F. Stancato, Thomas A. Engler, Michele Dowless, Wayne Blosser, Jonathan Low, Jeffrey J. Sutherland
High-content screening is increasingly used to elucidate changes in cellular biology arising from treatment with small molecules and biological probes. We describe a cell classifier for automated analysis of multiparametric data from immunofluorescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b06462c285bd76ec86c08603796625ed
https://doi.org/10.1158/1535-7163.c.6535402
https://doi.org/10.1158/1535-7163.c.6535402
Autor:
Swapnalee Sarmah, Courtney Curtis, Jennifer Mahin, Mark Farrell, Thomas A. Engler, Manuel V. Sanchez-Felix, Masahiko Sato, Yanfai Linda Ma, Shaoyou Chu, James A. Marrs
Publikováno v:
Biomedicines, Vol 7, Iss 2, p 30 (2019)
The Wnt pathway has been shown to regulate bone homeostasis and to influence some bone disease states. We utilized a zebrafish model system to study the effects of a synthetic, orally bioavailable glycogen synthase kinase-3β (GSK3β) inhibitor LSN 2
Externí odkaz:
https://doaj.org/article/3b4d8252ada24ba08d3603b12cb2af7a
Autor:
Christopher T. Reutter, Kelly Wayne Furness, David Anthony Barda, Thomas A. Engler, Rachel N. Cavitt, Michael J. Chalmers, Rebecca Leon, Junpeng Xiao, John Strelow, Aruna B. Wijeratne, Mohammad Zia-Ebrahimi, Robert D. Van Horn, Sheng-Bin Peng
Publikováno v:
ACS Medicinal Chemistry Letters. 9:557-562
[Image: see text] The KRASG12C protein product is an attractive, yet challenging, target for small molecule inhibition. One option for therapeutic intervention is to design small molecule ligands capable of binding to and inactivating KRASG12C via fo
Autor:
Yanfai Linda Ma, Shaoyou Chu, Masahiko Sato, Swapnalee Sarmah, Jennifer Mahin, Thomas A. Engler, Mark Farrell, Courtney Curtis, Manuel Sanchez-Felix, James A. Marrs
Publikováno v:
Biomedicines
Volume 7
Issue 2
Biomedicines, Vol 7, Iss 2, p 30 (2019)
Volume 7
Issue 2
Biomedicines, Vol 7, Iss 2, p 30 (2019)
The Wnt pathway has been shown to regulate bone homeostasis and to influence some bone disease states. We utilized a zebrafish model system to study the effects of a synthetic, orally bioavailable glycogen synthase kinase-3&beta
(GSK3&beta
(GSK3&beta
Autor:
Richard E. Higgs, Thomas A. Engler, Henry Uhlman Bryant, Ernst R. Dow, Mathias N'Cho, Bruce D. Gitter, Jude E. Onyia, Jianyong Shou, Trent R. Stewart, David L. Halladay, Tao Wei, T. John Martin, Yanfei L. Ma, Diane L. Sterchi, Amar Kumar, N.H. Kulkarni
Publikováno v:
Journal of Cellular Biochemistry. 102:1504-1518
Parathyroid hormone (PTH) and glycogen synthase kinase-3 (GSK-3) inhibitor 603281-31-8, administered once daily increased bone formation in vivo. We investigated the molecular mechanisms of the anabolic responses of PTH and 603281-31-8 in rat osteope
Autor:
Jennifer M. Atkinson, Jason Manro, Andrew Capen, Vipin Yadav, Thomas A. Engler, Yi Zeng, Kenneth B. Rank, Marcio Chedid
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0125028 (2015)
PLoS ONE, Vol 10, Iss 4, p e0125028 (2015)
It has previously been observed that a loss of β-catenin expression occurs with melanoma progression and that nuclear β-catenin levels are inversely proportional to cellular proliferation, suggesting that activation of the Wnt/β-catenin pathway ma
Autor:
Thomas W. Engler, Supalak Parn-anurak
Publikováno v:
Journal of Petroleum Science and Engineering. 46:149-160
A method was developed to simulate drilling fluid invasion of a two-phase system (water-based mud in an oil-bearing formation) and to subsequently evaluate the damage along a horizontal well. The proposed model includes fluid invasion, filter cake bu
Autor:
Donald B. Bennett, Brian Eugene Cunningham, Jill R. Wagner, Burkholder Timothy P, O'toole John Cunningham, Daniel A. Briere, David Mendel, Kelly Wayne Furness, Thomas A. Engler, Eric D. Hawkins, Jon K. Reel, Joseph T. Brozinick, Henry James Robert, Renee Vaughn, Robert M. Campbell, Joshua Ryan Clayton, Mclean Johnathan Alexander, Clive Gideon Diefenbacher, Timothy I. Meier, Richard A. Brier, Angela Lynn Marquart, Bryan D. Anderson, James A. Cook, Warren J. Porter, Yihong Li, Elizabeth A. Misener, Sushant Malhotra
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:899-903
Many 3-aryl-4-(1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl)maleimides exhibit potent GSK3 inhibitory activity (100 nM IC(50)), although few show significant selectivity (100x) versus CDK2, CDK4, or PKCbetaII. However, combining 3-(imidazo[1,