Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Thomas A Dieffenthaller"'
Autor:
Dean A Lee, Jeremiah L Oyer, Md Faqrul Hasan, Tayler J Croom-Perez, Liza D Robles-Carrillo, Sanjana Kumar, Brendan W Andersen, Brian P Tullius, Alicja J Copik, Amanda R Campbell, Thomas A Dieffenthaller, Catherine A Cash, Jonathan E Eloriaga, Meisam Naeimi Kararoudi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background Inhibitory receptor T-cell Immunoreceptor with Ig and ITIM domains (TIGIT) expressed by Natural Killer (NK) and T cells regulates cancer immunity and has been touted as the next frontier in the development of cancer immunotherapeutics. Alt
Externí odkaz:
https://doaj.org/article/4c6550d3cfe540f09ffbff19f9a789fa
Autor:
Jeremiah L. Oyer, Tayler J. Croom-Perez, Thomas A. Dieffenthaller, Liza D. Robles-Carillo, Sarah B. Gitto, Deborah A. Altomare, Alicja J. Copik
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
There is a great interest in developing natural killer (NK) cells as adoptive cancer immunotherapy. For off-the-shelf approaches and to conduct multicenter clinical trials, cryopreserved NK cells are the preferred product. However, recent studies rep
Externí odkaz:
https://doaj.org/article/29e98c27f36e4709aaf856cfeec9eaf2
Autor:
Md Faqrul Hasan, Tayler J. Croom-Perez, Jeremiah L. Oyer, Thomas A. Dieffenthaller, Liza D. Robles-Carrillo, Jonathan E. Eloriaga, Sanjana Kumar, Brendan W. Andersen, Alicja J. Copik
Publikováno v:
Cancers; Volume 15; Issue 10; Pages: 2712
Treatments targeting TIGIT have gained a lot of attention due to strong preclinical and early clinical results, particularly with anti-PD-(L)1 therapeutics. However, this combination has failed to meet progression-free survival endpoints in phase III
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290eca34a9ebaaa0d3a6549c6abaebe3
Publikováno v:
Cancer Research. 82:2819-2819
In this study we propose to circumvent HLA-E/NKG2A mediated Natural Killer (NK) cell inhibition by suppression of NKG2A, to enhance cytotoxicity of ex vivo expanded NK cells. One mechanism employed by tumor cells to evade immunosurveillance is throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09933153effe600edf465c7f3ad983be
https://doi.org/10.1158/1538-7445.am2022-2819
https://doi.org/10.1158/1538-7445.am2022-2819