Zobrazeno 1 - 10
of 392
pro vyhledávání: '"Thomas A Bowden"'
Autor:
Kamel El Omari, Ramona Duman, Vitaliy Mykhaylyk, Christian M. Orr, Merlyn Latimer-Smith, Graeme Winter, Vinay Grama, Feng Qu, Kiran Bountra, Hok Sau Kwong, Maria Romano, Rosana I. Reis, Lutz Vogeley, Luca Vecchia, C. David Owen, Sina Wittmann, Max Renner, Miki Senda, Naohiro Matsugaki, Yoshiaki Kawano, Thomas A. Bowden, Isabel Moraes, Jonathan M. Grimes, Erika J. Mancini, Martin A. Walsh, Cristiane R. Guzzo, Raymond J. Owens, E. Yvonne Jones, David G. Brown, Dave I. Stuart, Konstantinos Beis, Armin Wagner
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Despite recent advances in cryo-electron microscopy and artificial intelligence-based model predictions, a significant fraction of structure determinations by macromolecular crystallography still requires experimental phasing, usually by mea
Externí odkaz:
https://doaj.org/article/8684a241320c432f8b25757e0cf6d695
Autor:
Nathaniel S. Chapman, Ruben J. G. Hulswit, Jonna L. B. Westover, Robert Stass, Guido C. Paesen, Elad Binshtein, Joseph X. Reidy, Taylor B. Engdahl, Laura S. Handal, Alejandra Flores, Brian B. Gowen, Thomas A. Bowden, James E. Crowe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a dual-mechanism human monoclonal antibody (mAb) combination against RVFV
Externí odkaz:
https://doaj.org/article/b9951ffe5c244d7b912906b85005d70b
Autor:
Alice J. Stelfox, Kasopefoluwa Y. Oguntuyo, Ilona Rissanen, Karl Harlos, Robert Rambo, Benhur Lee, Thomas A. Bowden
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Increased viral surveillance has led to the isolation and identification of numerous uncharacterized paramyxoviruses, rapidly expanding our understanding of paramyxoviral diversity beyond the bounds of known genera. Despite this diversity, a
Externí odkaz:
https://doaj.org/article/92817af984f24736a7422fd40ac06895
Autor:
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mark Hassall, Jehad Alzahrani, Guido C. Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J. Doores, Neil A. Ranson, Martin Stacey, Mark Page, Nicola J. Rose, Thomas A. Bowden, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens. Virus-like particles (VLPs) form the basis of two of the most successful licensed vaccin
Externí odkaz:
https://doaj.org/article/b7c301ef9e3a4446bd7a97505024123b
Publikováno v:
BMJ Health & Care Informatics, Vol 29, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/031a99ac66a0410cb12d11d714bb5bc0
Autor:
Marina Escalera-Zamudio, Michael Golden, Bernardo Gutiérrez, Julien Thézé, Jeremy Russell Keown, Loic Carrique, Thomas A. Bowden, Oliver G. Pybus
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Highly pathogenic avian influenza viruses (HPAIV) can evolve via acquisition of polybasic cleavage sites, but the contribution of other mutations remains unclear. Here, the authors combine phylogenetic, statistical and structural approaches, and iden
Externí odkaz:
https://doaj.org/article/e5ea426da8054ddd9dbfead64f616866
Autor:
Weng M. Ng, Mehmet Sahin, Stefanie A. Krumm, Jeffrey Seow, Antra Zeltina, Karl Harlos, Guido C. Paesen, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTf
Externí odkaz:
https://doaj.org/article/c0526be8772c4f10948cbdf141eb261d
Autor:
Yasunori Watanabe, Zachary T. Berndsen, Jayna Raghwani, Gemma E. Seabright, Joel D. Allen, Oliver G. Pybus, Jason S. McLellan, Ian A. Wilson, Thomas A. Bowden, Andrew B. Ward, Max Crispin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Glycosylation plays a key role in shielding of immunogenic epitopes on viral spike (S) proteins. Here Watanabe et al. report that glycans of coronavirus SARS and MERS S proteins are heterogeneously distributed and do not form an efficacious high-dens
Externí odkaz:
https://doaj.org/article/9870ee47e6b94013917875773aa8dfd3
Autor:
Ilona Rissanen, Stefanie A. Krumm, Robert Stass, Annalis Whitaker, James E. Voss, Emily A. Bruce, Sylvia Rothenberger, Stefan Kunz, Dennis R. Burton, Juha T. Huiskonen, Jason W. Botten, Thomas A. Bowden, Katie J. Doores
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Hantaviruses are a group of emerging pathogens capable of causing severe disease upon zoonotic transmission to humans. The mature hantavirus surface presents higher-order tetrameric assemblies of two glycoproteins, Gn and Gc, which are respo
Externí odkaz:
https://doaj.org/article/1f67558141a14b57a4f6668f7781b182
Autor:
Hector Moreno, Alberto Rastrojo, Rhys Pryce, Chiara Fedeli, Gert Zimmer, Thomas A Bowden, Gisa Gerold, Stefan Kunz
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0009004 (2020)
A detailed understanding of the mechanisms underlying the capacity of a virus to break the species barrier is crucial for pathogen surveillance and control. New World (NW) mammarenaviruses constitute a diverse group of rodent-borne pathogens that inc
Externí odkaz:
https://doaj.org/article/ba98da8d367242fbb8fb02a727b6c6d6