Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Thomas A Angelovich"'
Autor:
Janna Jamal Eddine, Thomas A Angelovich, Jingling Zhou, Sarah J Byrnes, Carolin Tumpach, Nadia Saraya, Emily Chalmers, Rory A Shepherd, Abigail Tan, Stephanie Marinis, Paul R Gorry, Jacob D Estes, Bruce J Brew, Sharon R Lewin, Sushama Telwatte, Michael Roche, Melissa J Churchill
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012446 (2024)
HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated neurocognitive disorders. Whether HIV transcription persists in the brain despite viral suppression with antiretroviral therapy (ART) and is subject to t
Externí odkaz:
https://doaj.org/article/a288983a01634826840f2cf6e23b2dd3
Autor:
Sarah J Byrnes, Kathleen Busman-Sahay, Thomas A Angelovich, Skyler Younger, Sol Taylor-Brill, Michael Nekorchuk, Stephen Bondoc, Rachel Dannay, Margaret Terry, Catherine R Cochrane, Trisha A Jenkins, Michael Roche, Claire Deleage, Steven E Bosinger, Mirko Paiardini, Bruce J Brew, Jacob D Estes, Melissa J Churchill
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011290 (2023)
HIV-associated neurocognitive disorders (HAND) affect ~40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent changes to the brain are unclear. Here we characterized the CNS reservoir and immune environm
Externí odkaz:
https://doaj.org/article/a8b2d780e7df44039d495cd700b5e282
Autor:
Genevieve E Martin, Maelenn Gouillou, Anna C Hearps, Thomas A Angelovich, Allen C Cheng, Fiona Lynch, Wan-Jung Cheng, Geza Paukovics, Clovis S Palmer, Richard M Novak, Anthony Jaworowski, Alan L Landay, Suzanne M Crowe
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55279 (2013)
Aging is associated with immune dysfunction and the related development of conditions with an inflammatory pathogenesis. Some of these immune changes are also observed in HIV infection, but the interaction between immune changes with aging and HIV in
Externí odkaz:
https://doaj.org/article/f27ee7ace80b47d3b2b345e51fbe26a5
Autor:
Sarah J. Byrnes, Thomas A. Angelovich, Kathleen Busman-Sahay, Catherine R. Cochrane, Michael Roche, Jacob D. Estes, Melissa J. Churchill
Publikováno v:
Viruses, Vol 14, Iss 9, p 1997 (2022)
Human Immunodeficiency virus (HIV)-associated neurocognitive disorders are a major burden for people living with HIV whose viremia is stably suppressed with antiretroviral therapy. The pathogenesis of disease is likely multifaceted, with contribution
Externí odkaz:
https://doaj.org/article/7ed0552c021a4568aac3c9f296d8bbf9
Autor:
Sarah Buckley, Sarah Byrnes, Catherine Cochrane, Michael Roche, Jacob D. Estes, Stavros Selemidis, Thomas A. Angelovich, Melissa J. Churchill
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 13, Iss , Pp 100235- (2021)
HIV-associated neurocognitive disorders (HAND) are a leading cause of morbidity in up to 50% of individuals living with HIV, despite effective treatment with antiretroviral therapy (ART). Current evidence suggests that chronic inflammation associated
Externí odkaz:
https://doaj.org/article/cf648187d167432aabb9c5ea18f2bf24
Autor:
Matthew J, Gartner, Carolin, Tumpach, Ashanti, Dantanarayana, Jared, Stern, Jennifer M, Zerbato, J Judy, Chang, Thomas A, Angelovich, Jenny L, Anderson, Jori, Symons, Steve G, Deeks, Jacqueline K, Flynn, Sharon R, Lewin, Melissa J, Churchill, Paul R, Gorry, Michael, Roche
Publikováno v:
AIDS. 37:247-257
Despite suppressive antiretroviral therapy (ART), HIV can persist in a diverse range of CD4+ T-cell subsets. Through longitudinal env sampling from people with HIV (PWH) on ART, we characterized the persistence and phenotypic properties of HIV envs o
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Combination antiretroviral therapy (ART) is effective at suppressing HIV viremia to achieve persistently undetectable levels in peripheral blood in the majority of individuals with access and ability to maintain adherence to treatment. However, evide
Externí odkaz:
https://doaj.org/article/0594ba44d2d34547a02156d66a8bc070
Autor:
Anna C. Hearps, Paul A. Agius, Jingling Zhou, Samantha Brunt, Mkunde Chachage, Thomas A. Angelovich, Paul U. Cameron, Michelle Giles, Patricia Price, Julian Elliott, Anthony Jaworowski
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Innate immune dysfunction persists in HIV+ individuals despite effective combination antiretroviral therapy (cART). We recently demonstrated that an adaptive-like CD56dim NK cell population lacking the signal transducing protein FcRγ is expanded in
Externí odkaz:
https://doaj.org/article/06636b4a7a4f40e0848f42b51328421b
Autor:
Catherine R. Cochrane, Thomas A. Angelovich, Sarah J. Byrnes, Emily Waring, Aleks C. Guanizo, Gemma S. Trollope, Jingling Zhou, Judith Vue, Lachlan Senior, Emma Wanicek, Janna Jamal Eddine, Matthew J. Gartner, Trisha A. Jenkins, Paul R. Gorry, Bruce J. Brew, Sharon R. Lewin, Jacob D. Estes, Michael Roche, Melissa J. Churchill
Publikováno v:
Annals of neurology. 92(4)
Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier to HIV cure and possible cause of comorbid disease. However, the size and replication competent nature of the central nervous syste
Autor:
Jennifer F Hoy, Thomas A Angelovich, Anna C. Hearps, Michelle E. Wong, Janine M Trevillyan, Paul A. Agius, Anthony Jaworowski
Publikováno v:
AIDS. 34:513-518
OBJECTIVE People living with HIV have an increased risk of cardiovascular disease (CVD) despite effective antiretroviral therapy (ART). Monocytes play a key role in the early stages of atherosclerosis-driven CVD by forming lipid-laden foam cells with