Zobrazeno 1 - 10
of 462
pro vyhledávání: '"Thomas W. Kensler"'
Autor:
Christina Morgenstern, Isabel Lastres-Becker, Birsen Can Demirdöğen, Vera Marisa Costa, Andreas Daiber, Roberta Foresti, Roberto Motterlini, Sibel Kalyoncu, Burak I. Arioz, Sermin Genc, Monika Jakubowska, Ioannis P. Trougakos, Aleksandra Piechota-Polanczyk, Michel Mickael, Marlene Santos, Thomas W. Kensler, Antonio Cuadrado, Ian M. Copple
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103134- (2024)
The cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation. Hence, an ability to mo
Externí odkaz:
https://doaj.org/article/f50d81e6b4e544bc8942767d3919a61a
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4712 (2024)
The hepatic deletion of Rbpjκ (RbpjF/F::AlbCre) in the mouse leads to exhibition of the Alagille syndrome phenotype during early postnatal liver development with hyperlipidemia and cholestasis due to attenuated disruption of NOTCH signaling. Given t
Externí odkaz:
https://doaj.org/article/de08ed721c124a22b683adfd46219a2c
A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells
Autor:
Liam Baird, Keiko Taguchi, Anqi Zhang, Yushi Takahashi, Takafumi Suzuki, Thomas W. Kensler, Masayuki Yamamoto
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102845- (2023)
While it is well established that the KEAP1-NRF2 pathway regulates the main inducible cellular response to oxidative stress, this cytoprotective function of NRF2 could become deleterious to the host if it confers survival onto irreparably damaged cel
Externí odkaz:
https://doaj.org/article/05330e90b7e04718bade953250368fe1
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13345 (2023)
Lipodystrophy is a disorder featuring loss of normal adipose tissue depots due to impaired production of normal adipocytes. It leads to a gain of fat deposition in ectopic tissues such as liver and skeletal muscle that results in steatosis, dyslipide
Externí odkaz:
https://doaj.org/article/80b39a3d48854d0a9e6d11ab451fc81f
Autor:
Akira Uruno, Daisuke Saigusa, Takafumi Suzuki, Akane Yumoto, Tomohiro Nakamura, Naomi Matsukawa, Takahiro Yamazaki, Ristumi Saito, Keiko Taguchi, Mikiko Suzuki, Norio Suzuki, Akihito Otsuki, Fumiki Katsuoka, Eiji Hishinuma, Risa Okada, Seizo Koshiba, Yoshihisa Tomioka, Ritsuko Shimizu, Masaki Shirakawa, Thomas W. Kensler, Dai Shiba, Masayuki Yamamoto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Akira Uruno et al. report the volume of epidydimal white adipose tissue and plasma glycerophospholipid and sphingolipid levels in mice increase during spaceflight. These metabolic and physiological changes were largely driven by Nrf2 (NF-E2-related f
Externí odkaz:
https://doaj.org/article/4d30a972dc234a618c53b81a1176cb9d
Autor:
Jed W. Fahey, Thomas W. Kensler
Publikováno v:
Food Frontiers, Vol 2, Iss 3, Pp 235-239 (2021)
Abstract That phytochemicals are a critical part of enhancing healthspan is in our minds a linchpin of responsible public health messaging, yet, recent dietary guidelines and strategies for implementing precision nutrition largely ignore roles of phy
Externí odkaz:
https://doaj.org/article/3ef9279bc0cb4cd28e328f709d4b36e8
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-11 (2021)
Abstract Background Adolescence and early adulthood has been identified as a critical time window for establishing breast cancer risk. Mammographic density is an independent risk factor for breast cancer that may be influenced by diet, but there has
Externí odkaz:
https://doaj.org/article/39890dc537c447e693fce5692bc7913d
Publikováno v:
Cancer Biology & Medicine, Vol 16, Iss 1, Pp 24-37 (2019)
Qidong (Jiangsu, China) has been of interest to cancer epidemiologists and biologists because, until recently, it was an endemic area for liver cancer, having amongst the highest incidence rates in the world. The establishment of the Qidong Cancer Re
Externí odkaz:
https://doaj.org/article/5bd5abbc0ea7469a9d69eeb513ed3f24
Autor:
Joshua W. Smith, Robert N. O’Meally, Sean M. Burke, Derek K. Ng, Jian-Guo Chen, Thomas W. Kensler, John D. Groopman, Robert N. Cole
Publikováno v:
Journal of the American Society for Mass Spectrometry. 34:595-607
Autor:
Jed W. Fahey, Thomas W. Kensler
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Broccoli sprouts are a convenient and rich source of the glucosinolate glucoraphanin, which can generate the chemopreventive agent sulforaphane through the catalytic actions of plant myrosinase or β-thioglucosidases in the gut microflora. Sulforapha
Externí odkaz:
https://doaj.org/article/24f80a7fb0934ab09e63687c94fdce95