Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Thomas H. Lubben"'
NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells
Autor:
Marie K. Schwinn, Thomas H. Lubben, Lance P. Encell, Thomas Machleidt, Christopher T. Eggers, Thomas A. Kirkland, Mary P. Hall, Brock Binkowski, Keith V. Wood, Braeden L. Butler, Paul Otto, Kris Zimmerman, Andrew S. Dixon, Monika G. Wood
Publikováno v:
ACS chemical biology. 11(2)
Protein-fragment complementation assays (PCAs) are widely used for investigating protein interactions. However, the fragments used are structurally compromised and have not been optimized nor thoroughly characterized for accurately assessing these in
Autor:
James M. Trevillyan, Elizabeth H. Fry, Eric F. Johnson, Chaohong Sun, Hing L. Sham, Charles W. Hutchins, Thomas H. Lubben, Bruce G. Szczepankiewicz, Edward T. Olejniczak, Michael A. Stashko, Cele Abad-Zapatero, Michael D. Serby, Rebecca J. Gum, Hongyu Zhao, Kristi Haskins, Zhili Xin, Bo Liu, Sarah A Dorwin, Jill E. Clampit, Nelson Lissa T, Gang Liu, Mei Liu, Christi Kosogof, Cristina M. Rondinone, Sanyi Wang, Deanna L. Haasch
Publikováno v:
Journal of Medicinal Chemistry. 49:3563-3580
The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as by cellular stresses including chemotoxins, peroxides, and i
Autor:
Michael A. Stashko, Michael R. Jirousek, Philip J. Hajduk, Tianyuan Zhang, Stephen J. Ballaron, Charles W. Hutchins, Thomas H. Lubben, Bruce G. Szczepankiewicz, James M. Trevillyan, Zhonghua Pei, Cele Abad-Zapatero, Gang Liu, Xiaofeng Li, Zhili Xin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3947-3950
Monoacid-based PTP1B inhibitors with improved physiochemical properties have been investigated. A (2-hydroxy-phenoxy) acetic acid-based phosphotyrosyl mimetic has been linked with an optimized second arylphosphate binding site ligand to produce compo
Autor:
Zhili Xin, Cele Abad-Zapatero, James M. Trevillyan, Cristina M. Rondinone, Hongyu Zhao, Zhonghua Pei, Thomas H. Lubben, Wiweka Kaszubska, Deanna L. Haasch, Gang Liu, Michael R. Jirousek, Stephen J. Ballaron, Charles W. Hutchins, Philip J. Hajduk
Publikováno v:
Journal of Medicinal Chemistry. 46:4232-4235
Using an NMR-based fragment screening and X-ray crystal structure-based assembly, starting with millimolar ligands for both the catalytic site and the second phosphotyrosine binding site, we have identified a small-molecule inhibitor of protein tyros
Autor:
Michael A. Stashko, Cele Abad-Zapatero, Bruce G. Szczepankiewicz, Michael R. Jirousek, Zhonghua Pei, Cathy Berg, Gang Liu, Stephen J. Ballaron, Zhili Xin, Philip J. Hajduk, Thomas H. Lubben, Heng Liang, Charles W. Hutchins, David A. Janowick, Cristina M. Rondinone, James M. Trevillyan
Publikováno v:
Journal of Medicinal Chemistry. 46:3437-3440
Protein tyrosine phosphatase (PTPase) 1B (PTP1B) has been implicated as a key negative regulator of both insulin and leptin signaling cascades. We identified several salicylic acid-based ligands for the second phosphotyrosine binding site of PTP1B us
Autor:
Charles W. Hutchins, Heng Liang, James M. Trevillyan, Zhonghua Pei, Zhili Xin, Philip J. Hajduk, Flora Huang, Stephen W. Fesik, Cele Abad-Zapatero, Bruce G. Szczepankiewicz, Gang Liu, Thomas H. Lubben, Michael R. Jirousek, Michael A. Stashko, Stephen J. Ballaron
Publikováno v:
Journal of the American Chemical Society. 125:4087-4096
Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that downregulates the insulin receptor. Inhibition of PTP1B is expected to improve insulin action, and the design of small molecule PTP1B inhibitors to treat type II diabetes has received consider
Autor:
Pierre Fraikin, Bernard Pirotte, Dominique Heymann, László G. Puskás, Thomas H. Lubben, Luca Munaron, C. Philippe, Susanna Antoniotti, Haim J. Wolfson, Zsolt Lo\\'rincz, Barbara Malawska, Antal Simay, C. Garcia-Echeverria, Péter Mátyus, Alessandra Fiorio Pla, Ruth Nussinov, Marcin Gruchala, Peter J. Scammells, Martin Eggert, Szilvia Vajda, Gurbir S. Bhatia, András Varró, Bruce G. Szczepankiewicz, Panagiotis Zoumpoulakis, Ildikó Varga, Mark S. Levi, Jerry Ryan Holder, Péter Krajcsi, Margaret A. Brimble, László Ürge, Thomas Mavromoustakos, Nastiti Wijayanti, William A. Banks, William H. Bunnelle, Zhonghua Pei, Krista R. Wilson, Paola Zaccone, David W. Dunne, O.M. Zack Howard, Tomozumi Imamichi, Gregory Y.H. Lip, Christine G. Joseph, Carrie Haskell-Luevano, Maria Zervou, R. Efremov, Ákos Kocsis, G.B. Mahady, Tingjun Hou, Marcel J. de Groot, David R. Davies, Thomas D.C. Thomas, Michael R. Schrimpf, Allen B. Reitz, Stewart B. Kirton, Boman G. Irani, Seppo Ylä-Herttuala, Xiaojie Xu, Zoltán Kovári, Uwe K. Zettl, Gang Liu, Andreas Klüter, Tivadar Rettegi, Rebecca Deprez-Poulain, Péter Kovács, László Károlyházy, Dimitra Hadjipavlou-Litina, Kuo-Chen Chou, Benoit Deprez, Ferenc Darvas, Mark Levis, Donald Small, M. Iqbal Choudhary, Thang K. Chiu, Julius Gy. Papp, Michael J. Dart, Pascal de Tullio, Atta-ur-Rahman, Andrzej Wilczynski, György Dormán, Himadri Roy, Russell C. Davis, C. Bor-Luen, Stephan Immenschuh, Michael D. Sosin, Alexandra Shulman-Peleg, Anne Cooke, Davide Lovisolo, Michael J. Sutcliffe, Dina Schneidman-Duhovny, Oranit Dror, Gunther Neeck, Aleksandar Todorovic, István Pénzes, Shalini Bhardwaj, Sally A. Hutchinson, P.R. Bernstein, Pierre Francotte, Cheryl P. Kordik, David A. Jans
Publikováno v:
Frontiers in Medicinal Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f72de8108bc0fb8e384ae8a8f7537eb
https://doi.org/10.2174/97816080546401130601
https://doi.org/10.2174/97816080546401130601
Autor:
Michael R. Jirousek, James M. Trevillyan, Michael A. Stashko, Thomas H. Lubben, Jill E. Clampit
Publikováno v:
Current Protocols in Pharmacology
Many hormone or growth factor receptors signal via the activation of protein-tyrosine kinases and phosphatases. Alteration of the phosphorylation state of tyrosine residues in certain proteins can directly regulate enzyme activity or cause formation
Publikováno v:
Biochemistry. 30:9716-9723
The spontaneous refolding of chemically denatured dihydrofolate reductase (DHFR) is completely arrested by chaperonin 60 (GroEL). This inhibition presumably results from the formation of a stable complex between chaperonin 60 and one or more intermed