Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Thomas A. Fey"'
Autor:
Stevan W. Djuric, Kennan C. Marsh, Gin C. Hsieh, Michael P. Sheets, Yung-Wu Chen, Thomas A. Fey, Cindy Henry, Karl W. Mollison, Rolf Wagner, Donna M. Gauvin, George W. Carter, James M. Trevillyan, Teresa A. Rosenberg, Sandra E. Burke, Steve J. Ballaron, Joy Bauch, Morey L. Smith
Publikováno v:
Journal of Cardiovascular Pharmacology. 49:228-235
Sirolimus (rapamycin) is an immunosuppressant used in preventing allograft rejection and in drug-eluting stents to prevent restenosis after angioplasty. Zotarolimus, an analogue of sirolimus, was designed to have a shorter in vivo half-life. Zotaroli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d70a94a47632b4c29594455a56393e
https://doi.org/10.1097/fjc.0b013e3180325b0a
https://doi.org/10.1097/fjc.0b013e3180325b0a
Autor:
Hovis M. Imade, Hing L. Sham, Liping Pan, Linda E. Chovan, Heidi S. Camp, Bryan K. Sorensen, Rodger F. Henry, Jiahong Wang, Atul Ramaiya, Mark M. Mullally, Rohde Jeffrey J, J.T. Link, William J. Chiou, Katina Monzon, Peer B. Jacobson, Thomas A. Fey, Kennan C. Marsh, Xiaoqing Deng, David W A Beno, DeAnne Stolarik, Brian A. Droz, Steven Fung, Michael E. Brune, Ernst U. Frevert, Marina A. Pliushchev, Qi Shuai, Dariusz Wodka
Publikováno v:
Journal of Medicinal Chemistry. 50:149-164
Starting from a rapidly metabolized adamantane 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor 22a, a series of E-5-hydroxy-2-adamantamine inhibitors, exemplified by 22d and (+/-)-22f, was discovered. Many of these compounds are po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740a7e4962595eb2ab50d7cba96e3da2
https://doi.org/10.1021/jm0609364
https://doi.org/10.1021/jm0609364
Autor:
Verlyn G. Schaefer, Michael D. Serby, Bo Liu, Christine A. Collins, H. Douglas Falls, Hongyu Zhao, Eugene N. Bush, Victoria Knourek-Segel, Theresa M Turner, Michael E. Brune, Gang Liu, Thomas A. Fey, Wiweka Kaszubska, Brian A. Droz, Christi Kosogof, Zhili Xin, David W A Beno, Robin Shapiro, Peer B. Jacobson, Bruce G. Szczepankiewicz, Mei Liu, Nelson Lissa T, Hing L. Sham
Publikováno v:
Journal of Medicinal Chemistry. 49:2568-2578
Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents. Inhibition of ghrelin actions w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d352477e306be3be634175471489d0
https://doi.org/10.1021/jm0510934
https://doi.org/10.1021/jm0510934
Autor:
Emily Lin, Robin Shapiro, Victoria Knourek-Segel, Michael E. Brune, Brian A. Droz, Thomas A. Fey, Peer B. Jacobson, Eugene N. Bush
Publikováno v:
Endocrine. 29:375-382
Dexfenfluramine (DEX) and sibutramine (SIB) are effective antiobesity agents. Their effects on weight control and hormone profile have not been previously studied in diet-switched diet-induced obese (DIO) mice, in which treatment is initiated upon ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bc4a9ba15f316e481d8d35260eebfd
https://doi.org/10.1385/endo:29:2:375
https://doi.org/10.1385/endo:29:2:375
Autor:
Thomas A. Fey, Junli Ma, Michael E. Brune, Masaki Nakane, Yan Chun Li, Doug Dixon, J. Ruth Wu-Wong
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 98:72-77
Deficiency in Vitamin D and its metabolites leads to a failure in bone formation primarily caused by dysfunctional mineralization, suggesting that Vitamin D analogs might stimulate osteoblastic bone formation and mineralization. In this study, we com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89867250b705a662bcc0beb033865ace
https://doi.org/10.1016/j.jsbmb.2005.07.007
https://doi.org/10.1016/j.jsbmb.2005.07.007
Autor:
Noah Tu, Kennan C. Marsh, Karl W. Mollison, Rolf Wagner, Gin C. Hsieh, Cynthia L. Henry, Merrill Nuss, Jay R. Luly, Denise Wilcox, Nwe Y. Bamaung, Benjamin C. Lane, Richard P. Carlson, Yung-Wu Chen, Thomas A. Fey, Luping Liu, Paul E. Wiedeman, Yat-Sun Or, James M. Trevillyan, George W. Carter, Peer B. Jacobson, Teresa A. Rosenberg, Stevan W. Djuric
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5340-5343
The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036756a7d35bbf41755d205775e590ad
https://doi.org/10.1016/j.bmcl.2005.06.106
https://doi.org/10.1016/j.bmcl.2005.06.106
Autor:
Christine A. Collins, Victoria Knourek-Segel, Philip R. Kym, Dariusz Wodka, Hing L. Sham, Brad J. Geddes, Rajesh R. Iyengar, Anil Vasudevan, Ju Gao, Su Jen Lai, Elizabeth K. Govek, Thomas A. Fey, Freeman Jennifer C, Gang Zhao, Dennis G Fry, Michael E. Brune, Jennifer Lee Che, Brian D. Dayton, Doug H. Falls, Kennan C. Marsh, Andrew J. Souers, James Brown, Jon Roses, Michael A. Patane, Matthew J. LaMarche, Cathleen Mcdowell, Lee C. Preusser, Lisa E. Hernandez, Mathew M. Mulhern, Courtney Cullis, Tom Marsilje, Sevan Brodjian, Lynch John K, Eugene N. Bush, Sells Todd B, Robin Shapiro, Christopher Blackburn, Andrew S. Judd, Glenn A. Reinhart
Publikováno v:
Journal of Medicinal Chemistry. 48:5888-5891
4-(1-Benzo[1,3]dioxol-5-ylmethylpiperidine-4-ylmethyl)-6-chlorochromen-2-one (7) is a potent, orally bioavailable melanin concentrating hormone receptor 1 (MCHr1) antagonist that causes dose-dependent weight loss in diet-induced obese mice. Further e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b385adec4f57fc115bc33dad4a4acdf7
https://doi.org/10.1021/jm050598r
https://doi.org/10.1021/jm050598r
Autor:
Irene Drizin, Jorge D. Brioni, Michael E. Kort, Hao Bai, Michael C. Fitzgerald, Robert J. Gregg, Linda L. King, Robert J. Altenbach, William A. Carroll, Lin Yi, Michael J. Coghlan, Rodger F. Henry, Rui Tang, Anthony V. Daza, Henry Zhang, Murali Gopalakrishnan, Michael E. Brune, Steven A. Buckner, Kristi L. Whiteaker, Thomas A. Fey, Sean C. Turner, Christopher Cassidy, Mark W. Holladay, Yiyuan Chen, Philip R. Kym, Ivan Milicic, James P. Sullivan
Publikováno v:
Journal of Medicinal Chemistry. 47:3163-3179
Structure−activity relationships were investigated on a novel series of sulfonyldihydropyridine-containing KATP openers. Ring sizes, absolute stereochemistry, and aromatic substitution were evaluated for KATP activity in guinea pig bladder cells us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48701963d5335233e58180eb726e63f5
https://doi.org/10.1021/jm030356w
https://doi.org/10.1021/jm030356w
Autor:
Thomas A. Fey, James P. Sullivan, Jorge D. Brioni, Linda L. King, James G. Strake, Michael E. Brune, Michael J. Coghlan, Murali Gopalakrishnan
Publikováno v:
Neurourology and Urodynamics. 22:147-155
Aims To compare in vivo the efficacy, potency, and bladder–vascular selectivity of ATP-sensitive potassium channel openers (KCOs), YM934 and (-)-cromakalim to a muscarinic antagonist, tolterodine in a novel partial outlet obstructed pig model. Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d59c0bac17cfa021c368e8137afb6a
https://doi.org/10.1002/nau.10103
https://doi.org/10.1002/nau.10103
Autor:
Michael P. Sheets, Karl W. Mollison, Cannon John Burns, Robin M Kolano, Morey L. Smith, Jay R. Luly, Yung-Wu Chen, Melissa S. Pong, Thomas A. Fey, Donna M. Gauvin, George W. Carter, Nikolaos M. Nikolaidis, Yat-Sun Or, Benjamin C. Lane, Kennan C. Marsh, Gin C. Hsieh, James M. Trevillyan
Publikováno v:
Journal of Investigative Dermatology. 112:729-738
T lymphocytes play a critical part in inflammatory skin diseases but are targeted by available therapies that have only partial efficacy, significant side-effects, or both. Because psoriasis, atopic dermatitis, and allergic contact hypersensitivity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83611ed3e1ea2610853c4ca908de9c9
https://doi.org/10.1046/j.1523-1747.1999.00567.x
https://doi.org/10.1046/j.1523-1747.1999.00567.x