Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Thomas Å, Pedersen"'
Autor:
Stine M. Præstholm, Catarina M. Correia, Victor E. Goitea, Majken S. Siersbæk, Mathilde Jørgensen, Jesper F. Havelund, Thomas Å. Pedersen, Nils J. Færgeman, Lars Grøntved
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109938- (2021)
Summary: The transition from a fasted to a fed state is associated with extensive transcriptional remodeling in hepatocytes facilitated by hormonal- and nutritional-regulated transcription factors. Here, we use a liver-specific glucocorticoid recepto
Externí odkaz:
https://doaj.org/article/830a919b1e394d2a9c82955554f4eaec
Autor:
Tina M. Tagmose, Karen-Margrethe Pedersen, Lone Pridal, Carsten E. Stidsen, Marie Ø. Pedersen, Zhaosheng Lin, Yuanyuan Zhang, Zhe Wan, Mercedes Ferreras, Helle Naver, Peter K. Nielsen, Zheng Cao, Yi Wang, Lennart Lykke, Josefine L. Christensen, Victoria S. Jensen, Valentina Manfè, Thomas Å. Pedersen, Eva Johansson, Peter Madsen, János T. Kodra, Martin Münzel, Leonardo De Maria, Erica Nishimura, Thomas B. Kjeldsen
Publikováno v:
Journal of Medicinal Chemistry. 65:2633-2645
Here, we describe molecular engineering of monovalent ultra-long acting two-chain insulin-Fc conjugates. Insulin-Fc conjugates were synthesized using trifunctional linkers with one amino reactive group for reaction with a lysine residue of insulin an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b517e3f0eea1d2de015b33913626c34
https://doi.org/10.1021/acs.jmedchem.1c02039
https://doi.org/10.1021/acs.jmedchem.1c02039
Autor:
Christian Bindesbøll, Qiong Fan, Rikke C. Nørgaard, Laura MacPherson, Hai-Bin Ruan, Jing Wu, Thomas Å. Pedersen, Knut R. Steffensen, Xiaoyong Yang, Jason Matthews, Susanne Mandrup, Hilde I. Nebb, Line M. Grønning-Wang
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 4, Pp 771-785 (2015)
Liver X receptor (LXR)α and LXRβ play key roles in hepatic de novo lipogenesis through their regulation of lipogenic genes, including sterol regulatory element-binding protein (SREBP)-1c and carbohydrate responsive element-binding protein (ChREBP).
Externí odkaz:
https://doaj.org/article/ea74357040794890a9059321a49a7f5b
Autor:
Henning Hvid, Christian L. Brand, Tina Hummelshøj, Sanne Jensen, Stephan D. Bouman, Andrew Bowler, Bjarne R. Poulsen, Peter Tiainen, Thorbjörn Åkertröm, Damien Demozay, Thomas Hoeg-Jensen, Camilla Ingvorsen, Thomas Å. Pedersen, Jim McGuire, Thomas Egebjerg, Karen A. Cappelen, Ina P. Eliasen, Bo F. Hansen, Stephanie Hennen, Carsten E. Stidsen, Grith S. Olsen, Nikolaj K. Roed
Publikováno v:
Diabetologia. 66(2)
Aims/hypothesis Normalisation of blood glucose in individuals with diabetes is recommended to reduce development of diabetic complications. However, risk of severe hypoglycaemia with intensive insulin therapy is a major obstacle that prevents many in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89a9f61c32ff3fc5f78040483b515db
https://pubmed.ncbi.nlm.nih.gov/36404376
https://pubmed.ncbi.nlm.nih.gov/36404376
Autor:
Marie S Hasemann, Mikkel B Schuster, Anne-Katrine Frank, Kim Theilgaard-Mönch, Thomas Å Pedersen, Claus Nerlov, Bo T Porse
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38841 (2012)
BackgroundTranscription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical a
Externí odkaz:
https://doaj.org/article/435adf3ec52b4d42a64f1396f579cd8c
Autor:
Tine N Vinther, Mathias Norrman, Holger M Strauss, Kasper Huus, Morten Schlein, Thomas Å Pedersen, Thomas Kjeldsen, Knud J Jensen, František Hubálek
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30882 (2012)
An ingenious system evolved to facilitate insulin binding to the insulin receptor as a monomer and at the same time ensure sufficient stability of insulin during storage. Insulin dimer is the cornerstone of this system. Insulin dimer is relatively we
Externí odkaz:
https://doaj.org/article/56be5fcb4f9d42f782c421c1d91bc207
Autor:
Tine N, Vinther, Mathias, Norrman, Ulla, Ribel, Kasper, Huus, Morten, Schlein, Dorte B, Steensgaard, Thomas Å, Pedersen, Ingrid, Pettersson, Svend, Ludvigsen, Thomas, Kjeldsen, Knud J, Jensen, František, Hubálek
Publikováno v:
Protein science : a publication of the Protein Society. 22(3)
Insulin is a key hormone controlling glucose homeostasis. All known vertebrate insulin analogs have a classical structure with three 100% conserved disulfide bonds that are essential for structural stability and thus the function of insulin. It might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd6bec06fb7a4f24d6310e0381a742c6
https://pubmed.ncbi.nlm.nih.gov/23281053
https://pubmed.ncbi.nlm.nih.gov/23281053