Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Thomas, Worzfeld"'
Autor:
Felix Neuhaus, Sonja Lieber, Veronika Shinkevich, Anna Mary Steitz, Hartmann Raifer, Kathrin Roth, Florian Finkernagel, Thomas Worzfeld, Andreas Burchert, Corinna Keber, Andrea Nist, Thorsten Stiewe, Silke Reinartz, Vanessa M. Beutgen, Johannes Graumann, Kim Pauck, Holger Garn, Matthias Gaida, Rolf Müller, Magdalena Huber
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 4, Pp n/a-n/a (2024)
Abstract Background IL‐17A and TNF synergistically promote inflammation and tumorigenesis. Their interplay and impact on ovarian carcinoma (OC) progression are, however, poorly understood. We addressed this question focusing on mesothelial cells, w
Externí odkaz:
https://doaj.org/article/34a4cb60682e4aa7997d2f9cd82ee079
Autor:
Anna Mary Steitz, Clarissa Schröder, Isabel Knuth, Corinna U. Keber, Leah Sommerfeld, Florian Finkernagel, Julia M. Jansen, Uwe Wagner, Sabine Müller-Brüsselbach, Thomas Worzfeld, Magdalena Huber, Vanessa M. Beutgen, Johannes Graumann, Elke Pogge von Strandmann, Rolf Müller, Silke Reinartz
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108401- (2023)
Summary: A crucial requirement for metastasis formation in ovarian high-grade serous carcinoma (HGSC) is the disruption of the protective peritoneal mesothelium. Using co-culture systems of primary human cells, we discovered that tumor-associated NK
Externí odkaz:
https://doaj.org/article/e9c08e3135684fc89cfce67f8891a099
Autor:
Jona Schinner, Tomas Cunha, Johannes U. Mayer, Stefan Hörster, Peter Kind, Dario Didona, Corinna Keber, Michael Hertl, Thomas Worzfeld, Hazem A. Juratli
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionWe here thought to dissect the inflammatory signature in lesions of three skin disorders, which show a common adaptive immune response against autoantigens of the skin but are characterized by diverging clinical phenotypes. Pemphigus vulg
Externí odkaz:
https://doaj.org/article/37d5ee7a440a444bbade011147d5dd2b
Autor:
Chen Jiang, Ahsan Javed, Laura Kaiser, Michele M. Nava, Rui Xu, Dominique T. Brandt, Dandan Zhao, Benjamin Mayer, Javier Fernández-Baldovinos, Luping Zhou, Carsten Höß, Kovilen Sawmynaden, Arkadiusz Oleksy, David Matthews, Lee S. Weinstein, Heidi Hahn, Hermann-Josef Gröne, Peter L. Graumann, Carien M. Niessen, Stefan Offermanns, Sara A. Wickström, Thomas Worzfeld
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of
Externí odkaz:
https://doaj.org/article/c31e77abae1d4cc9839c925693d0c2fb
Autor:
Silke Reinartz, Sonja Lieber, Jelena Pesek, Dominique T. Brandt, Alina Asafova, Florian Finkernagel, Bernard Watzer, Wolfgang Andreas Nockher, Andrea Nist, Thorsten Stiewe, Julia M. Jansen, Uwe Wagner, Anne Konzer, Johannes Graumann, Robert Grosse, Thomas Worzfeld, Sabine Müller‐Brüsselbach, Rolf Müller
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 185-201 (2019)
The peritoneal fluid of ovarian carcinoma patients promotes cancer cell invasion and metastatic spread with lysophosphatidic acid (LPA) as a potentially crucial mediator. However, the origin of LPA in ascites and the clinical relevance of individual
Externí odkaz:
https://doaj.org/article/e7b07ecf563740a58d0b49e54170b0d7
Autor:
Boris Shorning, Neil Trent, David F. Griffiths, Thomas Worzfeld, Stefan Offermanns, Matthew J. Smalley, Magali Williamson
Publikováno v:
Cancer Research Communications. 3:444-458
Metastatic prostate cancer is essentially incurable and is a leading cause of cancer-related morbidity and mortality in men, yet the underlying molecular mechanisms are poorly understood. Plexins are transmembrane receptors for semaphorins with diver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f45007b70fe703f73527f0d0ce86103b
https://doi.org/10.1158/2767-9764.crc-22-0480
https://doi.org/10.1158/2767-9764.crc-22-0480
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Epithelial monolayer formation depends on the architecture and composition of the microtubule cytoskeleton. Microtubules control bidirectional trafficking and determine the positioning of structural cellular proteins. We studied the role of tubulin t
Externí odkaz:
https://doaj.org/article/8b08ca6948f44dc6b962c211c1e61417
Autor:
Eszter Paldy, Manuela Simonetti, Thomas Worzfeld, Kiran Kumar Bali, Lucas Vicuña, Stefan Offermanns, Rohini Kuner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Semaphorins and their receptors are involved in neurodevelopment, but their functions in the adult nervous system are not fully understood. This study finds that semaphorin 4C and its receptor Plexin B are expressed in sensory neurons and are pronoci
Externí odkaz:
https://doaj.org/article/527b909c401a4c5ebcc7de37bff5164a
Autor:
Johannes Graumann, Florian Finkernagel, Silke Reinartz, Thomas Stief, Dörte Brödje, Harald Renz, Julia M. Jansen, Uwe Wagner, Thomas Worzfeld, Elke Pogge von Strandmann, Rolf Müller
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
A central reason behind the poor clinical outcome of patients with high-grade serous carcinoma (HGSC) of the ovary is the difficulty in reliably detecting early occurrence or recurrence of this malignancy. Biomarkers that provide reliable diagnosis o
Externí odkaz:
https://doaj.org/article/bc0857ecbb7a40cf8070a9b78b91d7f6
Autor:
Ida Signe Bohse Larsen, Lorenzo Povolo, Luping Zhou, Weihua Tian, Kasper Johansen Mygind, John Hintze, Chen Jiang, Verity Hartill, Katrina Prescott, Colin A. Johnson, Sureni V. Mullegama, Allyn McConkie-Rosell, Marie McDonald, Lars Hansen, Sergey Y. Vakhrushev, Katrine T. Schjoldager, Henrik Clausen, Thomas Worzfeld, Hiren J. Joshi, Adnan Halim
Publikováno v:
Larsen, I S B, Povolo, L, Zhou, L, Tian, W, Mygind, K J, Hintze, J, Jiang, C, Hartill, V, Prescott, K, Johnson, C A, Mullegama, S V, McConkie-Rosell, A, McDonald, M, Hansen, L, Vakhrushev, S Y, Schjoldager, K T, Clausen, H, Worzfeld, T, Joshi, H J & Halim, A 2023, ' The SHDRA syndrome-associated gene TMEM260 encodes a protein-specific O-mannosyltransferase ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 21, pp. e2302584120 . https://doi.org/10.1073/pnas.2302584120
Mutations in the TMEM260 gene cause structural heart defects and renal anomalies syndrome, but the function of the encoded protein remains unknown. We previously reported wide occurrence of O-mannose glycans on extracellular immunoglobulin, plexin, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002d22943d971c680b2f7b4e379c7c4f
https://doi.org/10.1073/pnas.2302584120
https://doi.org/10.1073/pnas.2302584120