Zobrazeno 1 - 10
of 565
pro vyhledávání: '"Thomas, Werge"'
Autor:
Julie Courraud, Francesco Russo, Gonçalo Espregueira Themudo, Susan Svane Laursen, Andrés Ingason, David M. Hougaard, Arieh S. Cohen, Thomas Werge, Madeleine Ernst
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Large deletions at chromosome 22q11.2 are known to cause severe clinical conditions collectively known as 22q11.2 deletion syndrome. Notwithstanding the pathogenicity of these deletions, affected individuals are typically diagnosed in late c
Externí odkaz:
https://doaj.org/article/a050d5ab6328456b99c5b16d3916ae51
Autor:
Trine Munk-Olsen, Arianna Di Florio, Kathrine B. Madsen, Clara Albiñana, Merete L. Mægbæk, Veerle Bergink, Vibe G. Frøkjær, Esben Agerbo, Bjarni J. Vilhjálmsson, Thomas Werge, Merete Nordentoft, David M. Hougaard, Anders D. Børglum, Ole Mors, Preben Bo Mortensen, Xiaoqin Liu
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disor
Externí odkaz:
https://doaj.org/article/55dd8d9090d14f2ea460f664133aba97
Autor:
Emil M. Pedersen, Esben Agerbo, Oleguer Plana-Ripoll, Jette Steinbach, Morten D. Krebs, David M. Hougaard, Thomas Werge, Merete Nordentoft, Anders D. Børglum, Katherine L. Musliner, Andrea Ganna, Andrew J. Schork, Preben B. Mortensen, John J. McGrath, Florian Privé, Bjarni J. Vilhjálmsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Proportional hazards models have been proposed to analyse time-to-event phenotypes in genome-wide association studies (GWAS). However, little is known about the ability of proportional hazards models to identify genetic associations under di
Externí odkaz:
https://doaj.org/article/eb3d95affd73451ea109b0d277fe474f
Autor:
Clara Albiñana, Zhihong Zhu, Andrew J. Schork, Andrés Ingason, Hugues Aschard, Isabell Brikell, Cynthia M. Bulik, Liselotte V. Petersen, Esben Agerbo, Jakob Grove, Merete Nordentoft, David M. Hougaard, Thomas Werge, Anders D. Børglum, Preben Bo Mortensen, John J. McGrath, Benjamin M. Neale, Florian Privé, Bjarni J. Vilhjálmsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The predictive performance of polygenic scores (PGS) is largely dependent on the number of samples available to train the PGS. Increasing the sample size for a specific phenotype is expensive and takes time, but this sample size can be effec
Externí odkaz:
https://doaj.org/article/65c6fd7da745423fbb7f56199da61c83
Autor:
Mengyu Pan, James M. Roe, Ron Nudel, Andrew J. Schork, Olena Iakunchykova, Anders M. Fjell, Kristine B. Walhovd, Thomas Werge, Chi-hua Chen, Michael E. Benros, Yunpeng Wang
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Circulating levels of the astrocytic marker S100B have been associated with risk of neuropsychiatric or neurological disorders. However, reported effects have been inconsistent, and no causal relations have yet been established. We applied t
Externí odkaz:
https://doaj.org/article/1836c998574a4cc6bf53baff1d23771a
Autor:
Karina Banasik, Peter L. Møller, Tanya R. Techlo, Peter C. Holm, G. Bragi Walters, Andrés Ingason, Anders Rosengren, Palle D. Rohde, Lisette J. A. Kogelman, David Westergaard, Troels Siggaard, Piotr J. Chmura, Mona A. Chalmer, Ólafur Þ. Magnússon, Guðmundur Á. Þórisson, Hreinn Stefánsson, Daníel F. Guðbjartsson, Kári Stefánsson, Jes Olesen, Simon Winther, Morten Bøttcher, Søren Brunak, Thomas Werge, Mette Nyegaard, Thomas F. Hansen
Publikováno v:
BMC Genomic Data, Vol 24, Iss 1, Pp 1-4 (2023)
Abstract Objectives Allele counts of sequence variants obtained by whole genome sequencing (WGS) often play a central role in interpreting the results of genetic and genomic research. However, such variant counts are not readily available for individ
Externí odkaz:
https://doaj.org/article/e113e373bf77483e9c84853837f696bb
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 15, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/483c0456439f4e73aed157e211952282
Autor:
Clara Albiñana, Zhihong Zhu, Nis Borbye-Lorenzen, Sanne Grundvad Boelt, Arieh S. Cohen, Kristin Skogstrand, Naomi R. Wray, Joana A. Revez, Florian Privé, Liselotte V. Petersen, Cynthia M. Bulik, Oleguer Plana-Ripoll, Katherine L. Musliner, Esben Agerbo, Anders D. Børglum, David M. Hougaard, Merete Nordentoft, Thomas Werge, Preben Bo Mortensen, Bjarni J. Vilhjálmsson, John J. McGrath
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of
Externí odkaz:
https://doaj.org/article/15845a4d45ac43fd9c945f9f49a9c9cc
Autor:
Clara Albiñana, Zhihong Zhu, Nis Borbye-Lorenzen, Sanne Grundvad Boelt, Arieh S. Cohen, Kristin Skogstrand, Naomi R. Wray, Joana A. Revez, Florian Privé, Liselotte V. Petersen, Cynthia M. Bulik, Oleguer Plana-Ripoll, Katherine L. Musliner, Esben Agerbo, Anders D. Børglum, David M. Hougaard, Merete Nordentoft, Thomas Werge, Preben Bo Mortensen, Bjarni J. Vilhjálmsson, John J. McGrath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/9a04756801ae4be7b59d11f637177242
Autor:
Vivek Appadurai, Jonas Bybjerg-Grauholm, Morten Dybdahl Krebs, Anders Rosengren, Alfonso Buil, Andrés Ingason, Ole Mors, Anders D. Børglum, David M. Hougaard, Merete Nordentoft, Preben B. Mortensen, Olivier Delaneau, Thomas Werge, Andrew J. Schork
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
An analysis of phasing and imputation performances using iPSYCH consortium data across multiple methods and data integration protocols provides a useful framework in designing workflows to construct next-generation biobanks or conduct biobank-scale a
Externí odkaz:
https://doaj.org/article/da68746f7ed94072a9a90b5153feccaf