Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Thomas, Vifian"'
Autor:
Thomas Vifian, Tatiana G Stilou, Simon Feldbaek Nielsen, Maja Lambert, Jens Christian Højland Larsen, Tine Skak-Nielsen, Anders Soehoel, Pontus Hegardt, Lene M. Hansen, Nina Østergaard Knudsen, Morten Dahl Sørensen, Mogens Larsen, Cecilia Eskilsson, Steen Laursen, Stefan Eirefelt, Henrik Pettersson, Anna Ollerstam
Publikováno v:
Journal of Medicinal Chemistry. 63:14502-14521
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb38d7abc4b9986a9e38e75c9c4ae01
https://doi.org/10.1021/acs.jmedchem.0c00797
https://doi.org/10.1021/acs.jmedchem.0c00797
Autor:
Jens, Larsen, Maja, Lambert, Henrik, Pettersson, Thomas, Vifian, Mogens, Larsen, Anna, Ollerstam, Pontus, Hegardt, Cecilia, Eskilsson, Steen, Laursen, Anders, Soehoel, Tine, Skak-Nielsen, Lene M, Hansen, Nina Ø, Knudsen, Stefan, Eirefelt, Morten D, Sørensen, Tatiana G, Stilou, Simon F, Nielsen
Publikováno v:
Journal of medicinal chemistry. 63(23)
We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91d778dd5cf2a7a2234d7f9358d53149
https://pubmed.ncbi.nlm.nih.gov/33054196
https://pubmed.ncbi.nlm.nih.gov/33054196
Autor:
Mogens Trolle Larsen, Venkatarathnam Reddy Nasipireddy, Martin A. Carnerup, Paola Lovato, Jimmi Gerner Seitzberg, Andreas Ritzen, Burhardt Mia Norreskov, Thomas Vifian, Anders Jerre, Tue Heesgaard Jepsen, Jens Christian Højland Larsen, Rikke Sindet, Sanjay Rai, Bettina Borreschmidt Hansen, Christina Mølck
Publikováno v:
Journal of medicinal chemistry. 63(13)
Herein, we report the discovery of a series of JAK1-selective kinase inhibitors with high potency and excellent JAK family subtype selectivity. A fragment screening hit 1 with a pyrazolopyridone core and a JAK1 bias was selected as the starting point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886914e454d2cc366a197455d0cf4752
https://pubmed.ncbi.nlm.nih.gov/32462873
https://pubmed.ncbi.nlm.nih.gov/32462873