Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thomas, Seeholzer"'
Autor:
Mulatu Gashaw, Esayas Kebede Gudina, Solomon Ali, Liegl Gabriele, Thomas Seeholzer, Bikila Alemu, Guenter Froeschl, Arne Kroidl, Andreas Wieser
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
BackgroundIn resource-constrained settings, limited antibiotic options make treating carbapenem-resistant bacterial infections difficult for healthcare providers. This study aimed to assess carbapenemase expression in Gram-negative bacteria isolated
Externí odkaz:
https://doaj.org/article/76641fcfcb294368b0866b0d7184e328
Autor:
Mauro Di Pilato, Yun Gao, Yi Sun, Amina Fu, Carina Grass, Thomas Seeholzer, Regina Feederle, Irina Mazo, Samuel W. Kazer, Kevin Litchfield, Ulrich H. von Andrian, Thorsten R. Mempel, Russell W. Jenkins, Daniel Krappmann, Peter Keller
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 6, Iss 2, Pp 61-73 (2023)
Introduction: Regulatory T cells (Tregs) play a critical role in the maintenance of immune homeostasis but also protect tumors from immune-mediated growth control or rejection and pose a significant barrier to effective immunotherapy. Inhibition of M
Externí odkaz:
https://doaj.org/article/dc5e74a62a884d328a611a253bea0c01
Autor:
Mulatu Gashaw, Esayas Kebede Gudina, Wondwossen Tadesse, Guenter Froeschl, Solomon Ali, Thomas Seeholzer, Arne Kroidl, Andreas Wieser
Publikováno v:
Antibiotics, Vol 13, Iss 4, p 374 (2024)
The hospital environment is increasingly becoming an important reservoir for multi-drug-resistant (MDR) Gram-negative bacteria, posing serious challenges to efforts to combat antimicrobial resistance (AMR). This study aimed to investigate the role of
Externí odkaz:
https://doaj.org/article/8ce9bd6bb20142c6b7b99df056ec30ac
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
MALT1 is a core component of the CARD11-BCL10-MALT1 (CBM) signalosome, in which it acts as a scaffold and a protease to bridge T cell receptor (TCR) ligation to immune activation. As a scaffold, MALT1 binds to TRAF6, and T cell-specific TRAF6 ablatio
Externí odkaz:
https://doaj.org/article/8683bb0354b34951a566a912bf384599
Autor:
Jonathan J. Cho, Zhiwei Xu, Upasana Parthasarathy, Theodore T. Drashansky, Eric Y. Helm, Ashley N. Zuniga, Kyle J. Lorentsen, Samira Mansouri, Joshua Y. Cho, Mariola J. Edelmann, Duc M. Duong, Torben Gehring, Thomas Seeholzer, Daniel Krappmann, Mohammad N. Uddin, Danielle Califano, Rejean L. Wang, Lei Jin, Hongmin Li, Dongwen Lv, Daohong Zhou, Liang Zhou, Dorina Avram
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Ubiquitination may control protein stability or function. Here the authors show that an ubiquitination enzyme, Hectd3, ubiquitinates Stat3 and Malt1 to modulate their function but not degradation in T cells, and thereby promoting the differentiation
Externí odkaz:
https://doaj.org/article/1894c8d823ab4177ab03857c322a339c
Autor:
Ying-Yin Chao, Alisa Puhach, David Frieser, Mahima Arunkumar, Laurens Lehner, Thomas Seeholzer, Albert Garcia-Lopez, Marlot van der Wal, Silvia Fibi-Smetana, Axel Dietschmann, Thomas Sommermann, Tamara Ćiković, Leila Taher, Mark S. Gresnigt, Sebastiaan J. Vastert, Femke van Wijk, Gianni Panagiotou, Daniel Krappmann, Olaf Groß, Christina E. Zielinski
Publikováno v:
Nature Immunology. 24:295-308
It has been shown that innate immune responses can adopt adaptive properties such as memory. Whether T cells utilize innate immune signaling pathways to diversify their repertoire of effector functions is unknown. Gasdermin E (GSDME) is a membrane po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92bcd8312dc3f137a187cc7cbaa49676
https://doi.org/10.1038/s41590-022-01386-w
https://doi.org/10.1038/s41590-022-01386-w
Autor:
Florian Schlauderer, Thomas Seeholzer, Ambroise Desfosses, Torben Gehring, Mike Strauss, Karl-Peter Hopfner, Irina Gutsche, Daniel Krappmann, Katja Lammens
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mut
Externí odkaz:
https://doaj.org/article/22b52c92e3104c5888ae0b4dd5745f98
Autor:
Isabel Meininger, Richard A. Griesbach, Desheng Hu, Torben Gehring, Thomas Seeholzer, Arianna Bertossi, Jan Kranich, Andrea Oeckinghaus, Andrea C. Eitelhuber, Ute Greczmiel, Andreas Gewies, Marc Schmidt-Supprian, Jürgen Ruland, Thomas Brocker, Vigo Heissmeyer, Florian Heyd, Daniel Krappmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
MALT1 regulates NFκB signalling both as a scaffolding protein and as a protease. Here the authors show that during T cell activation the expression of MALT1 gene switches to an alternatively spliced variant, which increases TCR signal transduction d
Externí odkaz:
https://doaj.org/article/b82a72dd5f0a44099bcaaa35fbf30349
Autor:
Thomas Seeholzer, Susanne Kurz, Florian Schlauderer, Simone Woods, Torben Gehring, Simon Widmann, Katja Lammens, Daniel Krappmann
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Assembly of the CARD11/CARMA1-BCL10-MALT1 (CBM) signaling complex upon T or B cell antigen receptor (TCR or BCR) engagement drives lymphocyte activation. Recruitment of pre-assembled BCL10-MALT1 complexes to CARD11 fosters activation of the MALT1 pro
Externí odkaz:
https://doaj.org/article/44900b1a0ec8485092c5ae44783ffb2c
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Since the B-cell lymphoma/leukemia 10 (BCL10) protein was first described in 1999, numerous studies have elucidated its key functions in channeling adaptive and innate immune signaling downstream of CARMA/caspase-recruitment domain (CARD) scaffold pr
Externí odkaz:
https://doaj.org/article/ca5080c71568479b934868fa962a3757