Zobrazeno 1 - 10
of 645
pro vyhledávání: '"Thomas, Ried"'
Autor:
Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nousome, Claire Kuo, Jiji Jiang, Yongmei Chen, Reinhard Ebner, Isabell A. Sesterhenn, Joel T. Moncur, Gregory T. Chesnut, Gyorgy Petrovics, Gregory T. Klus, Gabor Valcz, Pier Vitale Nuzzo, Dezso Ribli, Judit Börcsök, Aurel Prosz, Marcin Krzystanek, Thomas Ried, David Szuts, Kinza Rizwan, Salma Kaochar, Shailja Pathania, Alan D. D’Andrea, Istvan Csabai, Shiv Srivastava, Matthew L. Freedman, Albert Dobi, Sandor Spisak, Zoltan Szallasi
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)
Abstract We analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1
Externí odkaz:
https://doaj.org/article/3508a45a6daf4e298c016ff52086528b
Autor:
Aurel Prosz, Haohui Duan, Viktoria Tisza, Pranshu Sahgal, Sabine Topka, Gregory T. Klus, Judit Börcsök, Zsofia Sztupinszki, Timothy Hanlon, Miklos Diossy, Laura Vizkeleti, Dag Rune Stormoen, Istvan Csabai, Helle Pappot, Joseph Vijai, Kenneth Offit, Thomas Ried, Nilay Sethi, Kent W. Mouw, Sandor Spisak, Shailja Pathania, Zoltan Szallasi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Due to a demonstrated lack of DNA repair deficiencies, clear cell renal cell carcinoma (ccRCC) has not benefitted from targeted synthetic lethality-based therapies. We investigated whether nucleotide excision repair (NER) deficiency is prese
Externí odkaz:
https://doaj.org/article/939969bbc4324201be410156a45cd9e5
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108814- (2024)
Summary: A long CGG-repeat tract in the FMR1 gene induces the epigenetic silencing that causes fragile X syndrome (FXS). Epigenetic changes include H4K20 trimethylation, a heterochromatic modification frequently implicated in transcriptional silencin
Externí odkaz:
https://doaj.org/article/398907151c9f4a538caeef7f8c4c68d4
Autor:
Martin Lang, Laura S. Schmidt, Kelli M. Wilson, Christopher J. Ricketts, Carole Sourbier, Cathy D. Vocke, Darmood Wei, Daniel R. Crooks, Youfeng Yang, Benjamin K. Gibbs, Xiaohu Zhang, Carleen Klumpp-Thomas, Lu Chen, Rajarshi Guha, Marc Ferrer, Crystal McKnight, Zina Itkin, Darawalee Wangsa, Danny Wangsa, Amy James, Simone Difilippantonio, Baktir Karim, Francisco Morís, Thomas Ried, Maria J. Merino, Ramaprasad Srinivasan, Craig J. Thomas, W. Marston Linehan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background MiT-Renal Cell Carcinoma (RCC) is characterized by genomic translocations involving microphthalmia-associated transcription factor (MiT) family members TFE3, TFEB, or MITF. MiT-RCC represents a specific subtype of sporadic RCC tha
Externí odkaz:
https://doaj.org/article/6b0458681f774fc788c19d8f3ed9c6d2
Autor:
Juliane Friemel, Irianna Torres, Elizabeth Brauneis, Tim Thörner, Alejandro A. Schäffer, E. Michael Gertz, Tobias Grob, Kati Seidl, Achim Weber, Thomas Ried, Kerstin Heselmeyer-Haddad
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Nonalcoholic steatohepatitis (NASH)-induced hepatocellular carcinoma (HCC) and its precursor, nonalcoholic fatty liver disease (NAFLD) are an unmet health issue due to widespread obesity. We assessed copy number changes of genes associated w
Externí odkaz:
https://doaj.org/article/10d6221a6a564d01ae9307dfc0dda781
Autor:
Sushant Patkar, Kerstin Heselmeyer-Haddad, Noam Auslander, Daniela Hirsch, Jordi Camps, Daniel Bronder, Markus Brown, Wei-Dong Chen, Rachel Lokanga, Darawalee Wangsa, Danny Wangsa, Yue Hu, Annette Lischka, Rüdiger Braun, Georg Emons, B. Michael Ghadimi, Jochen Gaedcke, Marian Grade, Cristina Montagna, Yuri Lazebnik, Michael J. Difilippantonio, Jens K. Habermann, Gert Auer, Eytan Ruppin, Thomas Ried
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)
Abstract Background Many carcinomas have recurrent chromosomal aneuploidies specific to the tissue of tumor origin. The reason for this specificity is not completely understood. Methods In this study, we looked at the frequency of chromosomal arm gai
Externí odkaz:
https://doaj.org/article/5ccb78cdd26b4762976deb16d27ec9ec
Autor:
Hendrik Ruge, MD, Erion Xhepa, MD, PhD, Michael Joner, MD, Christian König, MD, Thomas Ried, MD, Emin Imeri, MD, Ulf Herold, MD, Markus Krane, MD, Ruediger Lange, MD, PhD, Magdalena Erlebach, MD
Publikováno v:
JACC: Case Reports, Vol 3, Iss 4, Pp 653-657 (2021)
Valve disease in the presence of porcelain aorta and severe peripheral artery disease challenge physicians in choosing the appropriate therapy. We used a total transcatheter approach, simultaneously implanting a dedicated mitral and aortic valve pros
Externí odkaz:
https://doaj.org/article/9694397aeeb24918855552d4d0c6d82d
Autor:
Markus A. Brown, Gabrielle A. Dotson, Scott Ronquist, Georg Emons, Indika Rajapakse, Thomas Ried
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 257-269 (2021)
Canonical Wnt signaling is crucial for intestinal homeostasis as TCF4, the major Wnt signaling effector in the intestines, is required for stem cell maintenance. The capability of TCF4 to maintain the stem cell phenotype is contingent upon β-catenin
Externí odkaz:
https://doaj.org/article/a80fff0935484d40bfb552aec6752f7f
Autor:
Daniel Bronder, Anthony Tighe, Darawalee Wangsa, Dali Zong, Thomas J. Meyer, René Wardenaar, Paul Minshall, Daniela Hirsch, Kerstin Heselmeyer-Haddad, Louisa Nelson, Diana Spierings, Joanne C. McGrail, Maggie Cam, André Nussenzweig, Floris Foijer, Thomas Ried, Stephen S. Taylor
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 11 (2021)
High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN). However, direct causes of CIN, such as mutations in DNA replication and
Externí odkaz:
https://doaj.org/article/1ed0a95aaa3c4657908b60ea8e97da1b
Autor:
Darawalee Wangsa, Rüdiger Braun, Christina H. Stuelten, Markus Brown, Kerry M. Bauer, Georg Emons, Leigh A. Weston, Yue Hu, Howard H. Yang, Maria Vila-Casadesús, Maxwell P. Lee, Philip Brauer, Lidia Warner, Madhvi Upender, Amanda B. Hummon, Jordi Camps, Thomas Ried
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 7, Pp 721-729 (2019)
Chromosomal aneuploidy is a defining feature of epithelial cancers. The pattern of aneuploidies is cancer-type specific. For instance, the gain of chromosome 13 occurs almost exclusively in colorectal cancer. We used microcell-mediated chromosome tra
Externí odkaz:
https://doaj.org/article/423c89043e55402983a7a4b7e01513da