Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Thomas, Ricketts"'
Publikováno v:
BMC Health Services Research, Vol 21, Iss 1, Pp 1-29 (2021)
Abstract Background In recent years, there has been a growing interest in health care personalization and customization (i.e. personalized medicine and patient-centered care). While some positive impacts of these approaches have been reported, there
Externí odkaz:
https://doaj.org/article/adb8437ef25949b3b843cc363eb505be
Autor:
Andrea Paolini, Saleh Omairi, Robert Mitchell, Danielle Vaughan, Antonios Matsakas, Sakthivel Vaiyapuri, Thomas Ricketts, David C. Rubinsztein, Ketan Patel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/3a43f4e03d724ff9822170a1b58196ae
Autor:
Mariana Pavel, So Jung Park, Rebecca A. Frake, Sung Min Son, Marco M. Manni, Carla F. Bento, Maurizio Renna, Thomas Ricketts, Fiona M. Menzies, Radu Tanasa, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Autophagy regulates multiple pathways including YAP/TAZ of the Hippo pathway, but precise mechanisms are unclear as autophagy may either activate or inhibit YAP/TAZ. Here, the authors show that autophagy can either activate or regulate YAP/TAZ via dy
Externí odkaz:
https://doaj.org/article/d02b9e5043ae49d9b06eb7b9936822b7
Autor:
Farah H. Siddiqi, Fiona M. Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Rodrigo Ureshino, Thomas Ricketts, Maria Jimenez-Sanchez, Miguel Angel Esteban, Liangxue Lai, Micky D. Tortorella, Zhiwei Luo, Hao Liu, Emmanouil Metzakopian, Hugo J. R. Fernandes, Andrew Bassett, Eric Karran, Bruce L. Miller, Angeleen Fleming, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
A key challenge is to find/re-purpose approved drugs that could be used in humans to induce autophagy-associated clearance of neurodegenerative proteins. Here, authors demonstrate that felodipine, an anti-hypertensive drug, can induce autophagy and c
Externí odkaz:
https://doaj.org/article/faadda18e0ed4177b4aba46493d7b981
Autor:
Andrew Grundy, Anju Devianee Keetharuth, Rosemary Barber, Jill Carlton, Janice Connell, Elizabeth Taylor Buck, Michael Barkham, Thomas Ricketts, Dan Robotham, Diana Rose, John Kay, Rob Hanlon, John Brazier
Publikováno v:
Health and Quality of Life Outcomes, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background To provide a model for Public involvement (PI) in instrument development and other research based on lessons learnt in the co-production of a recently developed mental health patient reported outcome measure called Recovering Qual
Externí odkaz:
https://doaj.org/article/eb5d3f9927a34aecb3c9bc9e85abdb46
Autor:
Mariana Pavel, Maurizio Renna, So Jung Park, Fiona M. Menzies, Thomas Ricketts, Jens Füllgrabe, Avraham Ashkenazi, Rebecca A. Frake, Alejandro Carnicer Lombarte, Carla F. Bento, Kristian Franze, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
At high cell density or when plated on soft matrix, YAP/TAZ are redistributed from the nucleus to the cytosol, becoming transcriptionally inactive. Here the authors show that at high cell density, autophagosome formation is impaired due to reduced YA
Externí odkaz:
https://doaj.org/article/0cc58f26136b45e7a5358ff2da4265a7
Autor:
Galina Velikova, Jose M. Valderas, Caroline Potter, Laurie Batchelder, Christine A’Court, Matthew Baker, Jennifer Bostock, Angela Coulter, Ray Fitzpatrick, Julien Forder, Diane Fox, Louise Geneen, Elizabeth Gibbons, Crispin Jenkinson, Karen Jones, Laura Kelly, Michele Peters, Brendan Mulhern, Alexander Labeit, Donna Rowen, Keith Meadows, Jackie Elliott, John Brazier, Emma Knowles, Anju Keetharuth, Janice Connell, Jill Carlton, Lizzie Taylor Buck, Thomas Ricketts, Michael Barkham, Pushpendra Goswami, Sam Salek, Tatyana Ionova, Esther Oliva, Adele K. Fielding, Marina Karakantza, Saad Al-Ismail, Graham P. Collins, Stewart McConnell, Catherine Langton, Daniel M. Jennings, Roger Else, Jonathan Kell, Helen Ward, Sophie Day, Elizabeth Lumley, Patrick Phillips, Rosie Duncan, Helen Buckley-Woods, Ahmed Aber, Gerogina Jones, Jonathan Michaels, Ian Porter, Jaheeda Gangannagaripalli, Antoinette Davey, Ignacio Ricci-Cabello, Kirstie Haywood, Stine Thestrup Hansen, Jose Valderas, Deb Roberts, Anil Gumber, Bélène Podmore, Andrew Hutchings, Jan van der Meulen, Ajay Aggarwal, Sujith Konan, Andrew Price, William Jackson, Nick Bottomley, Michael Philiips, Toby Knightley-Day, David Beard, Joanne Greenhalgh, Kate Gooding, Chema Valderas, Judy Wright, Sonia Dalkin, David Meads, Nick Black, Carol Fawkes, Robert Froud, Dawn Carnes, Jonathan Cook, Helen Dakin, James Smith, Sujin Kang, The ACHE Study Team, Catrin Griffiths, Ella Guest, Diana Harcourt, Mairead Murphy, Sandra Hollinghurst, Chris Salisbury, Anqi Gao, Agnieszka Lemanska, Tao Chen, David P. Dearnaley, Rajesh Jena, Matthew Sydes, Sara Faithfull, A. E. Ades, Daphne Kounali, Guobing Lu, Ines Rombach, Alastair Gray, Oliver Rivero-Arias, Patricia Holch, Marie Holmes, Zoe Rodgers, Sarah Dickinson, Beverly Clayton, Susan Davidson, Jacqui Routledge, Julia Glennon, Ann M. Henry, Kevin Franks, Roma Maguire, Lisa McCann, Teresa Young, Jo Armes, Jenny Harris, Christine Miaskowski, Grigorios Kotronoulas, Morven Miller, Emma Ream, Elizabeth Patiraki, Alexander Geiger, Geir V. Berg, Adrian Flowerday, Peter Donnan, Paul McCrone, Kathi Apostolidis, Patricia Fox, Eileen Furlong, Nora Kearney, Chris Gibbons, Felix Fischer, Joel Coste, Jose Valderas Martinez, Matthias Rose, Alain Leplege, Sarah Shingler, Natalie Aldhouse, Tamara Al-Zubeidi, Andrew Trigg, Helen Kitchen, Colin Green, Joanna Coast, Sarah Smith, Jolijn Hendriks, Koonal Shah, Juan-Manuel Ramos-Goni, Simone Kreimeier, Mike Herdman, Nancy Devlin, Aureliano Paolo Finch, John E. Brazier, Clara Mukuria, Bernarda Zamora, David Parkin, Yan Feng, Andrew Bateman, Thomas Patton, Nils Gutacker
Publikováno v:
Health and Quality of Life Outcomes, Vol 15, Iss S1, Pp 1-12 (2017)
Externí odkaz:
https://doaj.org/article/6d25bc4e44af47719eddf53931531a73
Autor:
Xiaoting Wu, Angeleen Fleming, Thomas Ricketts, Mariana Pavel, Herbert Virgin, Fiona M. Menzies, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
The molecular mechanisms behind how autophagy may impact on developmental pathways and cell fate decisions are unclear. Here Wu et al.identify Notch receptors being taken up into ATG16L1-positive autophagosomes and, using a mouse mutant model, show t
Externí odkaz:
https://doaj.org/article/c71934f520734080a9c2a869599163df
Autor:
Farah H. Siddiqi, Fiona M. Menzies, Ana Lopez, Eleanna Stamatakou, Cansu Karabiyik, Rodrigo Ureshino, Thomas Ricketts, Maria Jimenez-Sanchez, Miguel Angel Esteban, Liangxue Lai, Micky D. Tortorella, Zhiwei Luo, Hao Liu, Emmanouil Metzakopian, Hugo J. R. Fernandes, Andrew Bassett, Eric Karran, Bruce L. Miller, Angeleen Fleming, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/036e4d2cf5454fa8add282b86c3b8f29
Autor:
Laura N. Purcell, Ali Eakes, Thomas Ricketts, Sean E. McLean, Adesola Akinkuotu, Andrea A. Hayes, Anthony G. Charles, Michael R. Phillips
Publikováno v:
The Journal of surgical research. 281
The delivery of pediatric surgical care for acute appendicitis involves general surgeons (GS) and pediatric surgeons (PS), but the differences in clinical practice are primarily undescribed. We examined charge differences between GS and PS for the tr