Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Thomas, Rathjen"'
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 96-105 (2018)
Objective: Actin cytoskeleton remodeling is necessary for glucose-stimulated insulin secretion in pancreatic β-cells. A mechanistic understanding of actin dynamics in the islet is paramount to a better comprehension of β-cell dysfunction in diabete
Externí odkaz:
https://doaj.org/article/719eab4614cd42cf889190c03e5d132c
Autor:
Thomas Rathjen, Britta Kunkemoeller, Carly T. Cederquist, Xuanchun Wang, Sam M. Lockhart, James C. Patti, Hanni Willenbrock, Grith Skytte Olsen, Gro Klitgaard Povlsen, Hans Christian Beck, Lars Melholt Rasmussen, Qian Li, Kyoungmin Park, George L. King, Christian Rask-Madsen
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Background: An activated, proinflammatory endothelium is a key feature in the development of complications of obesity and type 2 diabetes and can be caused by insulin resistance in endothelial cells. Methods: We analyzed primary human endothelial cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::872d19f129abef5518102e0778b67f9d
https://doi.org/10.1161/atvbaha.122.317476
https://doi.org/10.1161/atvbaha.122.317476
Autor:
Kyoungmin Park, Qian Li, George L. King, James C. Patti, Britta Kunkemoeller, Christian Rask-Madsen, Thomas Rathjen
Publikováno v:
Diabetes. 68
An activated, pro-inflammatory endothelium is a key feature of obesity and type 2 diabetes and may contribute to adipose tissue inflammation, atherosclerosis and tumor formation. We have previously published a striking 4-fold increase in leukocyte ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f985e4ae21ac48a1f1c9279fec2ca792
https://doi.org/10.2337/db19-273-lb
https://doi.org/10.2337/db19-273-lb
Autor:
Thomas Rathjen, Michael T. Watkins, Samuel M. Lockhart, Lars Melholt Rasmussen, Xuanchun Wang, Simone Rørdam Preil, Ditte Sørensen, Nishant Dwivedi, Brian T. O’Neill, Sally L. Dunwoodie, Hassan Albadawi, Christian Rask-Madsen, Hans Christian Beck
Publikováno v:
Diabetes
Wang, X, Lockhart, S M, Rathjen, T, Albadawi, H, Sørensen, D, O'Neill, B T, Dwivedi, N, Rørdam Preil, S, Beck, H C, Dunwoodie, S L, Watkins, M T, Rasmussen, L M & Rask-Madsen, C 2016, ' Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells ', Diabetes, vol. 65, no. 12, pp. 3680-3690 . https://doi.org/10.2337/db16-0001
Wang, X, Lockhart, S M, Rathjen, T, Albadawi, H, Sørensen, D, O'Neill, B T, Dwivedi, N, Rørdam Preil, S, Beck, H C, Dunwoodie, S L, Watkins, M T, Rasmussen, L M & Rask-Madsen, C 2016, ' Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells ', Diabetes, vol. 65, no. 12, pp. 3680-3690 . https://doi.org/10.2337/db16-0001
In patients with atherosclerotic complications of diabetes, impaired neovascularization of ischemic tissue in the myocardium and lower limb limits the ability of these tissues to compensate for poor perfusion. We identified 10 novel insulin-regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74d4d9ab5bab1543594bb3917cd4aab
http://europepmc.org/articles/PMC5127242
http://europepmc.org/articles/PMC5127242
Autor:
Kyoungmin Park, Grith Skytte Olsen, Gro Klitgaard Povlsen, Christian Rask-Madsen, Thomas Rathjen, Qian Li, George L. King
Publikováno v:
Diabetes. 67
An activated, pro-inflammatory endothelium is a key feature of obesity and type 2 diabetes but little is known about its contribution to the increased cancer risk in these conditions. We recently published that insulin resistance in endothelial cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e0f3aa929699f242289e3be18fbc3df
https://doi.org/10.2337/db18-2033-p
https://doi.org/10.2337/db18-2033-p
Publikováno v:
Molecular Metabolism
Objective Actin cytoskeleton remodeling is necessary for glucose-stimulated insulin secretion in pancreatic β-cells. A mechanistic understanding of actin dynamics in the islet is paramount to a better comprehension of β-cell dysfunction in diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4b83f18c93a4adb05fd0e390b927259
https://pubmed.ncbi.nlm.nih.gov/29310936
https://pubmed.ncbi.nlm.nih.gov/29310936
Autor:
Aygul, Subkhangulova, Anna R, Malik, Guido, Hermey, Oliver, Popp, Gunnar, Dittmar, Thomas, Rathjen, Matthew N, Poy, Alexander, Stumpf, Prateep Sanker, Beed, Dietmar, Schmitz, Tilman, Breiderhoff, Thomas E, Willnow
Publikováno v:
EMBO Reports
SORCS1 and SORCS3 are two related sorting receptors expressed in neurons of the arcuate nucleus of the hypothalamus. Using mouse models with individual or dual receptor deficiencies, we document a previously unknown function of these receptors in cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c3af65bcbe0883e5bb446532d920601
https://pubmed.ncbi.nlm.nih.gov/29440124
https://pubmed.ncbi.nlm.nih.gov/29440124
Autor:
Matt Kanke, Claus Oxvig, Sudhir Gopal Tattikota, Bailey C.E. Peck, Marcel Tarbier, Zhen Wang, Søren Gregersen, Matthew N. Poy, Xin Yan, Jan Frystyk, Thomas Rathjen, Marc R. Friedländer, Jakob Starup-Linde, Sidse Westberg-Rasmussen, Praveen Sethupathy
Publikováno v:
Yan, X, Wang, Z, Westberg-Rasmussen, S, Tarbier, M, Rathjen, T, Tattikota, S G, Peck, B C E, Kanke, M, Oxvig, C, Frystyk, J, Starup-Linde, J, Sethupathy, P, Friedländer, M R, Gregersen, S & Poy, M N 2017, ' Differential impact of glucose administered intravenously and orally on circulating miR-375 levels in human subjects ', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 10, pp. 3749-3755 . https://doi.org/10.1210/jc.2017-01365
Background To date, numerous nucleic acid species have been detected in the systemic circulation including microRNAs (miRNAs); however, their functional role in this compartment remains unclear. Objective The aim of this study was to determine whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56afd4fcb0cac73f982f001f2873f548
https://pubmed.ncbi.nlm.nih.gov/28973164
https://pubmed.ncbi.nlm.nih.gov/28973164
Autor:
Tamas L. Horvath, Louise van der Weyden, Chun-Xia Yi, Xin Yan, Valentina Tarallo, Andreas L. Birkenfeld, Dmytro Puchkov, Min Chi Ku, Anne Sophie Carlo, Sonja C. Schriever, Jan Siemens, Volker Haucke, Kun Song, Arnd Heuser, Luis Varela, Sudhir Gopal Tattikota, James F.A. Poulet, Mirko Moroni, Matthew N. Poy, Mirko Trajkovski, Matthias H. Tschöp, Natalia L. Kononenko, Thoralf Niendorf, Leiron Ferrarese, Gaga Kochlamazashvili, Matthias Heinig, Thomas Rathjen, Klara Szigeti-Buck, Sebastian Brachs
Publikováno v:
Nature neuroscience
Nature Neuroscience
Nat. Neurosci. 20, 1096-1103 (2017)
Nature neuroscience, 20(8), 1096-1103. Nature Publishing Group
Nature neuroscience, Vol. 20, No 8 (2017) pp. 1096-1103
Rathjen, T, Yan, X, Kononenko, N L, Ku, M-C, Song, K, Ferrarese, L, Tarallo, V, Puchkov, D, Kochlamazashvili, G, Brachs, S, Varela, L, Szigeti-Buck, K, Yi, C-X, Schriever, S C, Tattikota, S G, Carlo, A S, Moroni, M, Siemens, J, Heuser, A, van der Weyden, L, Birkenfeld, A L, Niendorf, T, Poulet, J F A, Horvath, T L, Tschöp, M H, Heinig, M, Trajkovski, M, Haucke, V & Poy, M N 2017, ' Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1 ', Nature Neuroscience, vol. 20, no. 8, pp. 1096-1103 . https://doi.org/10.1038/nn.4590
Nature Neuroscience
Nat. Neurosci. 20, 1096-1103 (2017)
Nature neuroscience, 20(8), 1096-1103. Nature Publishing Group
Nature neuroscience, Vol. 20, No 8 (2017) pp. 1096-1103
Rathjen, T, Yan, X, Kononenko, N L, Ku, M-C, Song, K, Ferrarese, L, Tarallo, V, Puchkov, D, Kochlamazashvili, G, Brachs, S, Varela, L, Szigeti-Buck, K, Yi, C-X, Schriever, S C, Tattikota, S G, Carlo, A S, Moroni, M, Siemens, J, Heuser, A, van der Weyden, L, Birkenfeld, A L, Niendorf, T, Poulet, J F A, Horvath, T L, Tschöp, M H, Heinig, M, Trajkovski, M, Haucke, V & Poy, M N 2017, ' Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1 ', Nature Neuroscience, vol. 20, no. 8, pp. 1096-1103 . https://doi.org/10.1038/nn.4590
Susceptibility to obesity is linked to genes regulating neurotransmission, pancreatic beta-cell function and energy homeostasis. Genome-wide association studies have identified associations between body mass index and two loci near cell adhesion mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b367621004e2f620bfe7fda4a58125a9
https://pubmed.ncbi.nlm.nih.gov/28628102
https://pubmed.ncbi.nlm.nih.gov/28628102
Autor:
Thomas Rathjen, Häring Mf, Monica M. Bertagnolli, Lars Melholt Rasmussen, Christian Rask-Madsen, Xuanchun Wang, Siegfried Ussar, Ditte Sørensen, Samuel M. Lockhart, Kahn Cr
Publikováno v:
Oncogene 36, 4987-4996 (2017)
Oncogene
Wang, X, Häring, M-F, Rathjen, T, Lockhart, S M, Sørensen, D, Ussar, S, Rasmussen, L M, Bertagnolli, M M, Kahn, C R & Rask-Madsen, C 2017, ' Insulin resistance in vascular endothelial cells promotes intestinal tumour formation ', Oncogene, vol. 36, no. 35, pp. 4987–4996 . https://doi.org/10.1038/onc.2017.107
Oncogene
Wang, X, Häring, M-F, Rathjen, T, Lockhart, S M, Sørensen, D, Ussar, S, Rasmussen, L M, Bertagnolli, M M, Kahn, C R & Rask-Madsen, C 2017, ' Insulin resistance in vascular endothelial cells promotes intestinal tumour formation ', Oncogene, vol. 36, no. 35, pp. 4987–4996 . https://doi.org/10.1038/onc.2017.107
The risk of several cancers, including colorectal cancer, is increased in patients with obesity and type 2 diabetes, conditions characterised by hyperinsulinaemia and insulin resistance. Because hyperinsulinaemia itself is an independent risk factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6d6ec1573a0c2e119962588be65c08
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51867
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51867
