Spatial and temporal dynamics of HDACs class IIa following mild traumatic brain injury in adult rats

Autor: Swatabdi R, Kamal, Shreya, Potukutchi, David J, Gelovani, Robin E, Bonomi, Srinivasu, Kallakuri, John M, Cavanaugh, Thomas, Mangner, Alana, Conti, Ren-Shyan, Liu, Renata, Pasqualini, Wadih, Arap, Richard L, Sidman, Shane A, Perrine, Juri G, Gelovani

Publikováno v: Molecular psychiatry. 27(3)

The fundamental role of epigenetic regulatory mechanisms involved in neuroplasticity and adaptive responses to traumatic brain injury (TBI) is gaining increased recognition. TBI-induced neurodegeneration is associated with several changes in the expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::646a9a07896a1aa810fed69b755e4b47
https://pubmed.ncbi.nlm.nih.gov/35027678

Molecular Imaging of Sirtuin1 Expression-Activity in Rat Brain Using Positron-Emission Tomography-Magnetic-Resonance Imaging with [

Autor: Robin, Bonomi, Vadim, Popov, Maxwell T, Laws, David, Gelovani, Anjoy, Majhi, Aleksandr, Shavrin, Xin, Lu, Otto, Muzik, Nashaat, Turkman, Renshyan, Liu, Thomas, Mangner, Juri G, Gelovani

Publikováno v: Journal of medicinal chemistry. 61(16)

Sirtuin 1 (SIRT1) is a class III histone deacetylase that plays significant roles in the regulation of lifespan, metabolism, memory, and circadian rhythms and in the mechanisms of many diseases. However, methods of monitoring the pharmacodynamics of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5af3a4f5f971c522d4b147aa9546cdc
https://pubmed.ncbi.nlm.nih.gov/30052441

Efficacy of Low-Dose Buspirone for Restricted and Repetitive Behavior in Young Children with Autism Spectrum Disorder: A Randomized Trial

Autor: Diane C. Chugani, Harry T. Chugani, Max Wiznitzer, Sumit Parikh, Patricia A. Evans, Robin L. Hansen, Ruth Nass, James J. Janisse, Pamela Dixon-Thomas, Michael Behen, Robert Rothermel, Jacqueline S. Parker, Ajay Kumar, Otto Muzik, David J. Edwards, Deborah Hirtz, Huiyuan Jiang, Lalitha Sivaswamy, Ginger Steinhilber, Kristin Kennedy, Kathy Pawlik, Ruth Roeder, Monica Malian, Hailey Turner, Amira Hanna, Jamie Katusin, Deanna Supula, Stacey Halverson, William Guy, Nore Gjolaj, Thomas Mangner, Pulak Chakraborty, Angela Wigeluk, Gregory Patterson, Andrew Mosqueda, Melissa Burkett, Anna DeBoard, Jane Cornett, Mei-li Lee, Xin Lu, Catherine Germain, Marianne Majkowski, Beth French, Amy Stolinski, Suzi Naguib, Courtney Wolfe-Christensen, Sara Taylor, Jamal Ameli, Julie Kemp McQueeney, Michelle Rubinlicht, Bethany Gorka, Erin Zacharski, Jeffrey L. Blumer, Kathleen Maxwell, Catherine Tasi, Philip Toltzis, Jolee Kalic, Dianne Morus, Jany Paulett, Bonnie Rosolowski, Michael Banchy, Kathryn Westlake, Barbara Calabro, Carol Tacket, Ina Adkins, Kenneth Buchheit, Kathryn Hepper, David Speicher, Susan Bergant, Jennifer Haky, Mary Beth Frohnapfel, Cindy Schaefer, Allison Browning, Roberta Bauer, Rebecca Embacher, Julie Knapp, Stephanie Levy, Diane Davies, Donna Lach, John Petrich, Sharon Kreischer, Patty Blubaugh, Mary Ann Morris, Carolyn Garver, Mariam Andersen, Meredith Greene, Amanda Richards, Maria Rocha, Ruth Merryman, Sailaja Golla, Alan Lorenzen, Julie Long Sherrod, Paulette Perryman, Kara Lorduy, Kathleen Angkustsiri, Lauren Back Plumer, Mary Jacena Siy Leigh, Susan C. Bacalman, Dorcas Liriano Roa, Kushma Govindappa, Gayatri Mahajan, Erika Bickel, Norman Brule, Emma Hare, Nadir Sarwary, Dominique Cargill, Joyce Lee, Smiley Hom, Dennis Steindorf, Mandy Pietrykowski, Kindra Root, Sarah Coffey, Elise Phelps Hanzel, Adriana Santana, Clara Ramirez, Stefanie Berci, Nielsen Gabriel, Glenn Hirsch, Elizabeth Roberts, Amanda Zwilling, Resham Gellatly, Dana Levy, Sandi Lee, Jennifer Rodman, Nora Oberfield, Susan Friedland, Catherine Lord, Rene Kozloff, Celeste Crouse, Stephanie Millen, Alex J. Coímbre, Kelly L. McCarter, David Posey

Publikováno v: The Journal of Pediatrics. 170:45-53.e4

Objectives To determine safety and efficacy of the 5HT 1A serotonin partial agonist buspirone on core autism and associated features in children with autism spectrum disorder (ASD). Study design Children 2-6 years of age with ASD (N = 166) were rando

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550e4e9df7b4e24e023057cb1eed27b9