Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Thomas, MacCarthy"'
Autor:
Zhixin Jing, Phillip Galbo, Luis Ovando, Megan Demouth, Skylar Welte, Rosa Park, Kartik Chandran, Yinghao Wu, Thomas MacCarthy, Deyou Zheng, David Fooksman
Publikováno v:
eLife, Vol 12 (2024)
Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intravital two-pho
Externí odkaz:
https://doaj.org/article/4054696222bc428b9f4c745ce34e05a2
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSomatic hypermutation (SHM) of immunoglobulin variable (V) regions by activation induced deaminase (AID) is essential for robust, long-term humoral immunity against pathogen and vaccine antigens. AID mutates cytosines preferentially withi
Externí odkaz:
https://doaj.org/article/d11d978934bc491dbfc9e80f4d7223f6
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109433- (2024)
Summary: Evolvability is an emergent hallmark of cancer that depends on intra-tumor heterogeneity and genetic variation. Mutations generated by APOBEC3 contribute to genetic variation and tumor evolvability. However, the influence of APOBEC3 on the e
Externí odkaz:
https://doaj.org/article/6f1270e3cfb7466ebbf1b9fe6e5edb60
Autor:
Changkun Hu, Taylor Bugbee, Rachel Palinski, Ibukun A Akinyemi, Michael T McIntosh, Thomas MacCarthy, Sumita Bhaduri-McIntosh, Nicholas Wallace
Publikováno v:
eLife, Vol 12 (2023)
Double strand breaks (DSBs) are one of the most lethal DNA lesions in cells. The E6 protein of beta-human papillomavirus (HPV8 E6) impairs two critical DSB repair pathways: homologous recombination (HR) and non-homologous end joining (NHEJ). However,
Externí odkaz:
https://doaj.org/article/b54c18b5addc4591aac934765ee5ce95
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103668- (2022)
Summary: B cells undergo somatic hypermutation (SHM) of the Immunoglobulin (Ig) variable region to generate high-affinity antibodies. SHM relies on the activity of activation-induced deaminase (AID), which mutates C>U preferentially targeting WRC (W=
Externí odkaz:
https://doaj.org/article/442898b0ad1443a1992181a50cecb318
Autor:
Guojun Yu, Yingru Wu, Zhi Duan, Catherine Tang, Haipeng Xing, Matthew D Scharff, Thomas MacCarthy
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009323 (2021)
The B cells in our body generate protective antibodies by introducing somatic hypermutations (SHM) into the variable region of immunoglobulin genes (IgVs). The mutations are generated by activation induced deaminase (AID) that converts cytosine to ur
Externí odkaz:
https://doaj.org/article/25eefab5715547d3ad7ca2a44510f15a
Autor:
Catherine Tang, Thomas MacCarthy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Activation-induced deaminase (AID) is a key enzyme involved in antibody diversification by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) of the Immunoglobulin (Ig) loci. AID preferentially targets WRC (W=A/T, R=A/G) hots
Externí odkaz:
https://doaj.org/article/ddb75068f8434bc8b857c7d4884b7e3d
Autor:
Davide Bagnara, Catherine Tang, Jennifer R. Brown, Siddha Kasar, Stacey Fernandes, Monica Colombo, Stefano Vergani, Andrea N. Mazzarello, Fabio Ghiotto, Silvia Bruno, Fortunato Morabito, Kanti R. Rai, Jonathan E. Kolitz, Jacqueline C. Barrientos, Steven L. Allen, Franco Fais, Matthew D. Scharff, Thomas MacCarthy, Nicholas Chiorazzi
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Analyses of IGHV gene mutations in chronic lymphocytic leukemia (CLL) have had a major impact on the prognostication and treatment of this disease. A hallmark of IGHV-mutation status is that it very rarely changes clonally over time. Nevertheless, ta
Externí odkaz:
https://doaj.org/article/d46eed87a5ff475f89423d3c64d17572
Autor:
Umberto Rosani, Chang-Ming Bai, Lorenzo Maso, Maxwell Shapiro, Miriam Abbadi, Stefania Domeneghetti, Chong-Ming Wang, Laura Cendron, Thomas MacCarthy, Paola Venier
Publikováno v:
BMC Evolutionary Biology, Vol 19, Iss 1, Pp 1-18 (2019)
Abstract Background Adenosine deaminase enzymes of the ADAR family are conserved in metazoans. They convert adenine into inosine in dsRNAs and thus alter both structural properties and the coding potential of their substrates. Acting on exogenous dsR
Externí odkaz:
https://doaj.org/article/fc3f18d393f6439aa8898c285bf8ac61
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009560 (2021)
Herpes-Simplex Virus 1 (HSV-1) infects most humans when they are young, sometimes with fatal consequences. Gene expression occurs in a temporal order upon lytic HSV-1 infection: immediate early (IE) genes are expressed, then early (E) genes, followed
Externí odkaz:
https://doaj.org/article/933cc266155440779da5ddce2af0324b