Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Thomas, Loustau"'
Autor:
Romina J. Walter, Steffen J. Sonnentag, Leonel Munoz-Sagredo, Melanie Merkel, Ludovic Richert, Felix Bunert, Yvonne M. Heneka, Thomas Loustau, Michael Hodder, Rachel A. Ridgway, Owen J. Sansom, Yves Mely, Ulrich Rothbauer, Mark Schmitt, Véronique Orian-Rousseau
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-16 (2022)
Abstract Enhancement of Wnt signaling is fundamental for stem cell function during intestinal regeneration. Molecular modules control Wnt activity by regulating signal transduction. CD44 is such a positive regulator and a Wnt target gene. While highl
Externí odkaz:
https://doaj.org/article/ba60973a08064619990c359bff0a4f13
Autor:
Aurore De Cauwer, Thomas Loustau, William Erne, Angélique Pichot, Anne Molitor, Tristan Stemmelen, Raphael Carapito, Gertraud Orend, Seiamak Bahram, Philippe Georgel
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105149- (2022)
Summary: Age-related diseases are major concern in developed countries. To avoid disabilities that accompany increased lifespan, pharmaceutical approaches are considered. Therefore, appropriate animal models are required for a better understanding of
Externí odkaz:
https://doaj.org/article/5f158a4994694ab8a4592e1762d08da7
Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression
Autor:
Devadarssen Murdamoothoo, Zhen Sun, Alev Yilmaz, Gilles Riegel, Chérine Abou‐Faycal, Claire Deligne, Ines Velazquez‐Quesada, William Erne, Marine Nascimento, Matthias Mörgelin, Gérard Cremel, Nicodème Paul, Raphael Carapito, Romain Veber, Hélène Dumortier, Jingping Yuan, Kim S Midwood, Thomas Loustau, Gertraud Orend
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 6, Pp 1-21 (2021)
Abstract Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti‐cancer treatment approach, yet with low response rates. The extracellular matrix, in particular tenascin‐C, may generate bar
Externí odkaz:
https://doaj.org/article/b3b3bbcf9e5c4240a68764406229c8d2
Autor:
Caroline Spenlé, Thomas Loustau, Hélène Burckel, Gilles Riegel, Chérine Abou Faycal, Chengbei Li, Alev Yilmaz, Luciana Petti, Fanny Steinbach, Constance Ahowesso, Camille Jost, Nicodème Paul, Raphael Carapito, Georges Noël, Fabienne Anjuère, Nathalie Salomé, Gertraud Orend
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Radiotherapy, the most frequent treatment of oral squamous cell carcinomas (OSCC) besides surgery is employed to kill tumor cells but, radiotherapy may also promote tumor relapse where the immune-suppressive tumor microenvironment (TME) could be inst
Externí odkaz:
https://doaj.org/article/cbcf966f96dc4030b911199750bf5a70
Autor:
Sayda Dhaouadi, Rahma Ben Abderrazek, Thomas Loustau, Chérine Abou-Faycal, Ayoub Ksouri, William Erne, Devadarssen Murdamoothoo, Matthias Mörgelin, Andreas Kungl, Alain Jung, Sonia Ledrappier, Zakaria Benlasfar, Sandrine Bichet, Ruth Chiquet-Ehrismann, Ismaïl Hendaoui, Gertraud Orend, Balkiss Bouhaouala-Zahar
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The extracellular matrix (ECM) molecule Tenascin-C (TNC) is well-known to promote tumor progression by multiple mechanisms. However, reliable TNC detection in tissues of tumor banks remains limited. Therefore, we generated dromedary single-domain nan
Externí odkaz:
https://doaj.org/article/d3eb277678b740599d23db7c782660b8
Autor:
Kim S. Midwood, Gertraud Orend, Zhen Sun, Imogen Mazzier, Inés Velazquez-Quesada, Nicodème Paul, Raphael Carapito, Anna M. Marzeda, Thomas Loustau, William Erne, Martha Gschwandtner, Anís N. Gammage, Devadarssen Murdamoothoo, Claire Deligne
The interplay between cancer cells and immune cells is a key determinant of tumor survival. Here, we uncovered how tumors exploit the immunomodulatory properties of the extracellular matrix to create a microenvironment that enables their escape from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1733f41e57eae86345e7ba64809d5b5e
https://doi.org/10.1158/2326-6066.c.6550338.v1
https://doi.org/10.1158/2326-6066.c.6550338.v1
Autor:
Gertraud Orend, Ellen Van Obberghen-Schilling, Fabienne Anjuère, Anne Sudaka, Shigeyuki Kon, Katja Schenke-Layland, Manuel Koch, Christopher G. Mueller, Hélène Dumortier, Christine Carapito, Aurélie Hirschler, Nicolas Pythoud, Raphael Carapito, Nicodème Paul, Uwe Hansen, Thomas Imhof, Kelly Nouhen, Sebastian Schaub, Samah Rekima, Abdouramane Camara, Vony Randrianarisoa, Gérard Cremel, Eva-Maria Brauchle, Matthias Mörgelin, Pierre Bourdely, Luciana Petti, Romain Veber, Stephanie Beghelli-de la Forest Divonne, William Erne, Devadarssen Murdamoothoo, Thomas Loustau, Caroline Spenlé
Supplemental Figures S1 - S7 Supplemental Tables S1 - S17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63df7bab4dcc75d0081b13cd449f832a
https://doi.org/10.1158/2326-6066.22542310
https://doi.org/10.1158/2326-6066.22542310
Autor:
Kim S. Midwood, Gertraud Orend, Zhen Sun, Imogen Mazzier, Inés Velazquez-Quesada, Nicodème Paul, Raphael Carapito, Anna M. Marzeda, Thomas Loustau, William Erne, Martha Gschwandtner, Anís N. Gammage, Devadarssen Murdamoothoo, Claire Deligne
Supplementary figures and table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697242ea3186c59ca7b6a72d7b9e790f
https://doi.org/10.1158/2326-6066.22543632
https://doi.org/10.1158/2326-6066.22543632
Autor:
Gertraud Orend, Ellen Van Obberghen-Schilling, Fabienne Anjuère, Anne Sudaka, Shigeyuki Kon, Katja Schenke-Layland, Manuel Koch, Christopher G. Mueller, Hélène Dumortier, Christine Carapito, Aurélie Hirschler, Nicolas Pythoud, Raphael Carapito, Nicodème Paul, Uwe Hansen, Thomas Imhof, Kelly Nouhen, Sebastian Schaub, Samah Rekima, Abdouramane Camara, Vony Randrianarisoa, Gérard Cremel, Eva-Maria Brauchle, Matthias Mörgelin, Pierre Bourdely, Luciana Petti, Romain Veber, Stephanie Beghelli-de la Forest Divonne, William Erne, Devadarssen Murdamoothoo, Thomas Loustau, Caroline Spenlé
Inherent immune suppression represents a major challenge in the treatment of human cancer. The extracellular matrix molecule tenascin-C promotes cancer by multiple mechanisms, yet the roles of tenascin-C in tumor immunity are incompletely understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23697c2938fb3e00969dd77509d68ef5
https://doi.org/10.1158/2326-6066.c.6549868.v1
https://doi.org/10.1158/2326-6066.c.6549868.v1
Autor:
Chérine Abou Fayçal, Andre Oszwald, Tobias Feilen, Miguel Cosenza-Contreras, Oliver Schilling, Thomas Loustau, Fanny Steinbach, Helga Schachner, Brigitte Langer, Peter Heeringa, Andrew J Rees, Gertraud Orend, Renate Kain
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology, 106, 12-33
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are severe inflammatory disorders that often involve focal necrotizing glomerulonephritis (FNGN) and consequent glomerular scarring, interstitial fibrosis, and chronic kidney d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91be63f81777bde719eed8665358ebc
https://doi.org/10.1016/j.matbio.2022.01.001
https://doi.org/10.1016/j.matbio.2022.01.001