Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas, Klünemann"'
Autor:
Federico Bertoglio, Viola Fühner, Maximilian Ruschig, Philip Alexander Heine, Leila Abassi, Thomas Klünemann, Ulfert Rand, Doris Meier, Nora Langreder, Stephan Steinke, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Philipp Kuhn, Peggy Riese, Dorina Schäckermann, Janin Korn, Allan Koch, M. Zeeshan Chaudhry, Kathrin Eschke, Yeonsu Kim, Susanne Zock-Emmenthal, Marlies Becker, Margitta Scholz, Gustavo Marçal Schmidt Garcia Moreira, Esther Veronika Wenzel, Giulio Russo, Hendrikus S.P. Garritsen, Sebastian Casu, Andreas Gerstner, Günter Roth, Julia Adler, Jakob Trimpert, Andreas Hermann, Thomas Schirrmann, Stefan Dübel, André Frenzel, Joop Van den Heuvel, Luka Čičin-Šain, Maren Schubert, Michael Hust
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109433- (2021)
Summary: The novel betacoronavirus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) causes a form of severe pneumonia disease called coronavirus disease 2019 (COVID-19). To develop human neutralizing anti-SARS-CoV-2 antibodies, antibody g
Externí odkaz:
https://doaj.org/article/9c2876f60a3849cc9e53afa0c2d3362e
Autor:
Marc Sevenich, Elena Thul, Nils-Alexander Lakomek, Thomas Klünemann, Maren Schubert, Federico Bertoglio, Joop van den Heuvel, Patrick Petzsch, Jeannine Mohrlüder, Dieter Willbold
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 441 (2022)
Severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious beta-class coronavirus. Although vaccinations have shown high efficacy, the emergence of novel variants of concern (VOCs) has already exhibited traits of immune evasion. Th
Externí odkaz:
https://doaj.org/article/a30d7e10cf784031bebef2c32e46f490
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
The crystal structure of the c-type cytochrome NirC from Pseudomonas aeruginosa has been determined and reveals the simultaneous presence of monomers and 3D domain-swapped dimers in the same asymmetric unit.
Monoheme c-type cytochromes are impor
Monoheme c-type cytochromes are impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7e0ebed589f8ef366793c5be230ce0
https://doi.org/10.1107/s2059798320003101
https://doi.org/10.1107/s2059798320003101
In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site
Autor:
Arnold Kloos, Kerstin Goerlich, Eduard A. Struys, Michelle Maria Araujo Cruz, Denis Grote-Koska, Julia Weder, Basem Othman, Thomas Klünemann, Charu Gupta, Arnold Ganser, Anuhar Chaturvedi, Ramya Goparaju, Matthias Preller, Heike Bähre, Michael Heuser, Renate Schottmann, Korbinian Brand
Publikováno v:
Chaturvedi, A, Goparaju, R, Gupta, C, Weder, J, Klünemann, T, Araujo Cruz, M M, Kloos, A, Goerlich, K, Schottmann, R, Othman, B, Struys, E A, Bähre, H, Grote-Koska, D, Brand, K, Ganser, A, Preller, M & Heuser, M 2020, ' In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site ', Leukemia, vol. 34, no. 2, pp. 416-426 . https://doi.org/10.1038/s41375-019-0582-x
Leukemia, 34(2), 416-426. Nature Publishing Group
Leukemia
Leukemia, 34(2), 416-426. Nature Publishing Group
Leukemia
Mutations in isocitrate dehydrogenase 1 (IDH1) are found in 6% of AML patients. Mutant IDH produces R-2-hydroxyglutarate (R-2HG), which induces histone- and DNA-hypermethylation through the inhibition of epigenetic regulators, thus linking metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca74d563472075d774da344fc2f4a3d1
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074391501&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074391501&origin=inward
Autor:
Falk Harnisch, Luis F. M. Rosa, Julia Adamczack, Wulf Blankenfeldt, Thomas Klünemann, Arne Preuß, Gunhild Layer
Publikováno v:
Journal of Molecular Biology. 431:3246-3260
Many bacteria can switch from oxygen to nitrogen oxides, such as nitrate or nitrite, as terminal electron acceptors in their respiratory chain. This process is called "denitrification" and enables biofilm formation of the opportunistic human pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9120e0da39db70f48ad489be844c4bf
https://doi.org/10.1016/j.jmb.2019.05.046
https://doi.org/10.1016/j.jmb.2019.05.046
Autor:
Wulf Blankenfeldt, Jhon Alexander Rodriguez Buitrago, Agustina Vila, Bastian Nicolai, Patrick Schrepfer, Paula Bracco, Dick B. Janssen, Hein J. Wijma, Thomas Klünemann, Anett Schallmey
Publikováno v:
ChemBioChem : a European journal of chemical biology 22(6), 1099-1110 (2020). doi:10.1002/cbic.202000735
ChemBioChem, 22(6), 1099-1110. WILEY-V C H VERLAG GMBH
Chembiochem : a European journal of chemical biology Bd. 22, H. 6 (2021), S. 1099-1110--Chembiochem--1439-4227--1439-7633
Chembiochem
Chembiochem : a European journal of chemical biology
Germany
ChemBioChem, 22(6), 1099-1110. WILEY-V C H VERLAG GMBH
Chembiochem : a European journal of chemical biology Bd. 22, H. 6 (2021), S. 1099-1110--Chembiochem--1439-4227--1439-7633
Chembiochem
Chembiochem : a European journal of chemical biology
Germany
CYP154C5 from Nocardia farcinica is a P450 monooxygenase able to hydroxylate a range of steroids with high regio‐ and stereoselectivity at the 16α‐position. Using protein engineering and substrate modifications based on the crystal structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ff3451b4d6411a2686e91616cfe5e0
https://publications.rwth-aachen.de/record/810303
https://publications.rwth-aachen.de/record/810303
Autor:
Sebastian Casu, Federico Bertoglio, Kristian Daniel Ralph Roth, Maren Schubert, Peggy Riese, Stephan Steinke, André Frenzel, Yeonsu Kim, Margitta Scholz, Michael Hust, Hendrikus S.P. Garritsen, Allan Koch, Thomas Schirrmann, Maximilian Ruschig, Rico Ballmann, Stefan Dübel, Günter Roth, Dorina Schäckermann, Giulio Russo, Ulfert Rand, Thomas Klünemann, Marlies Becker, Gustavo Marçal Schmidt Garcia Moreira, Philipp Kuhn, Janin Korn, Philip Alexander Heine, Doris Meier, Luka Cicin-Sain, Nora Langreder, Esther Veronika Wenzel, Kathrin Eschke, Andreas Gerstner, Viola Fühner, Julia Adler, Andreas Hermann, Susanne Zock-Emmenthal, Leila Abasi, Joop van den Heuvel, Jakob Trimpert, Kai-Thomas Schneider, M. Zeeshan Chaudhry
The novel betacoranavirus SARS-CoV-2 causes a form of severe pneumonia disease, termed COVID-19 (coronavirus disease 2019). Recombinant human antibodies are proven potent neutralizers of viruses and can block the interaction of viral surface proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d0ea4e53163c64198aa669c61357674
https://doi.org/10.1101/2020.12.03.409318
https://doi.org/10.1101/2020.12.03.409318
Monoheme c-type cytochromes are important electron transporters in all domains of life. They possess a common fold hallmarked by three α-helices that surround a covalently attached heme. An intriguing feature of many monoheme c-type cytochromes is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d53049957f332f7db326af2847e186d
Autor:
Thomas, Klünemann, Wulf, Blankenfeldt
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
The crystal structure of a heme d 1-free form of the cd 1 nitrite reductase NirS from Pseudomonas aeruginosa has been determined and provides insight into a premature form of the enzyme.
A key step in anaerobic nitrate respiration is the reducti
A key step in anaerobic nitrate respiration is the reducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9d52b9ee362d61bc4a4f14b8d772767
https://pubmed.ncbi.nlm.nih.gov/32510465
https://pubmed.ncbi.nlm.nih.gov/32510465
Publikováno v:
The FEBS journal 288(1), 244-261 (2021). doi:10.1111/febs.15323
The FEBS journal 288(1), 244 - 261 (2021). doi:10.1111/febs.15323
Certain facultative anaerobes such as the opportunistic human pathogen Pseudomonas aeruginosa can respire on nitrate, a process generally known as denitrification. This enables de
Certain facultative anaerobes such as the opportunistic human pathogen Pseudomonas aeruginosa can respire on nitrate, a process generally known as denitrification. This enables de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3fa8e7a9e04c28bce8c17928174172
https://doi.org/10.1101/2020.01.13.904656
https://doi.org/10.1101/2020.01.13.904656