Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Thomas, Jenuwein"'
Autor:
Raphaël Pantier, Megan Brown, Sicheng Han, Katie Paton, Stephen Meek, Thomas Montavon, Nicholas Shukeir, Toni McHugh, David A. Kelly, Tino Hochepied, Claude Libert, Thomas Jenuwein, Tom Burdon, Adrian Bird
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Correlative evidence has suggested that the methyl-CpG-binding protein MeCP2 contributes to the formation of heterochromatin condensates via liquid-liquid phase separation. This interpretation has been reinforced by the observation that hete
Externí odkaz:
https://doaj.org/article/8624fe27fea0477cbeee8d7082173fcb
Autor:
Thomas Montavon, Nicholas Shukeir, Galina Erikson, Bettina Engist, Megumi Onishi-Seebacher, Devon Ryan, Yaarub Musa, Gerhard Mittler, Alexandra Graff Meyer, Christel Genoud, Thomas Jenuwein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Histone H3K9 methylation (H3K9me) states define repressed chromatin in eukaryotic cells. Here the authors reveal complete loss of all H3K9me in mammalian cells through successive deletion of H3K9 methyltransferase genes that results in the dissolutio
Externí odkaz:
https://doaj.org/article/ffb762bd6b22494b91032351da989456
Autor:
Irene Santos-Barriopedro, Laia Bosch-Presegué, Anna Marazuela-Duque, Carolina de la Torre, Carlota Colomer, Berta N. Vazquez, Thomas Fuhrmann, Bárbara Martínez-Pastor, Wenfu Lu, Thomas Braun, Eva Bober, Thomas Jenuwein, Lourdes Serrano, Manel Esteller, Zhenbang Chen, Silvia Barceló-Batllori, Raúl Mostoslavsky, Lluis Espinosa, Alejandro Vaquero
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Sirtuins are involved in the regulation of responses to diverse types of cellular stress. Here the authors describe the SirT6-dependent cysteine monoubiquitination of the histone methyltransferase Suv39h1 as part of a regulatory circuit for the NF-κ
Externí odkaz:
https://doaj.org/article/5703e4bf0087489eaecd2013c1eb52d7
Autor:
Guang Yang, Xinyu Weng, Yuhao Zhao, Xinjian Zhang, Yuanping Hu, Xin Dai, Peng Liang, Peng Wang, LeiLei Ma, Xiaolei Sun, Lei Hou, Huihui Xu, Mingming Fang, Yuehua Li, Thomas Jenuwein, Yong Xu, Aijun Sun
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sir
Externí odkaz:
https://doaj.org/article/defedf8823f54aecb46bc1b1f72eb945
Autor:
Jing Qiu, Matteo Villa, David E. Sanin, Michael D. Buck, David O’Sullivan, Reagan Ching, Mai Matsushita, Katarzyna M. Grzes, Frances Winkler, Chih-Hao Chang, Jonathan D. Curtis, Ryan L. Kyle, Nikki Van Teijlingen Bakker, Mauro Corrado, Fabian Haessler, Francesca Alfei, Joy Edwards-Hicks, Leonard B. Maggi, Jr., Dietmar Zehn, Takeshi Egawa, Bertram Bengsch, Ramon I. Klein Geltink, Thomas Jenuwein, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2063-2074.e5 (2019)
Summary: Competition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic adaptation to the surrounding microenvironment is therefore key for maintaining appropriate cell fu
Externí odkaz:
https://doaj.org/article/4ea68f59d3e14e4bbf5687d54711cf4f
Autor:
Raphaël Pantier, Megan Brown, Sicheng Han, Katie Paton, Stephen Meek, Thomas Montavon, Toni McHugh, David A. Kelly, Tino Hochepied, Claude Libert, Thomas Jenuwein, Tom Burdon, Adrian Bird
Correlative evidence has suggested that DNA methylation promotes the formation of transcriptionally silent heterochromatin. Accordingly, the methyl-CpG binding domain protein MeCP2 is often portrayed as a constituent of heterochromatin. This interpre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d69aa2cb100d0541ef4b5596d423395
https://doi.org/10.1101/2023.05.09.539985
https://doi.org/10.1101/2023.05.09.539985
Supplementary Figure Legends 1-2 from DNA Methylation and Complete Transcriptional Silencing of Cancer Genes Persist after Depletion of EZH2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d4dc54b16342fabf8f5f53e4f756aa
https://doi.org/10.1158/0008-5472.22366344
https://doi.org/10.1158/0008-5472.22366344
Recent work suggests a link between the polycomb group protein EZH2 and mediation of gene silencing in association with maintenance of DNA methylation. However, we show that whereas basally expressed target cancer genes with minimal DNA methylation h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb9dd4023b7ab7ac3d510f827c68919
https://doi.org/10.1158/0008-5472.c.6495093.v1
https://doi.org/10.1158/0008-5472.c.6495093.v1
Supplementary Figures 1-2 from DNA Methylation and Complete Transcriptional Silencing of Cancer Genes Persist after Depletion of EZH2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55ce860bc611dcd38b6859195cb7b28
https://doi.org/10.1158/0008-5472.22366341.v1
https://doi.org/10.1158/0008-5472.22366341.v1
Autor:
Dounia Djeghloul, Andrew Dimond, Holger Kramer, Karen Brown, Bhavik Patel, Yi-Fang Wang, Matthias E. Futschik, Chad Whilding, Alex Montoya, Nicolas Veland, Sherry Cheriyamkunnel, Thomas Montavon, Thomas Jenuwein, Matthias Merkenschlager, Amanda G. Fisher
Publikováno v:
Nature Structural and Molecular Biology
Recent studies have shown that repressive chromatin machinery, including DNA methyltransferases and polycomb repressor complexes, binds to chromosomes throughout mitosis and their depletion results in increased chromosome size. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801713bb3925b3124205b3360f17ce1c
https://hdl.handle.net/21.11116/0000-000D-12B4-321.11116/0000-000D-12B6-1
https://hdl.handle.net/21.11116/0000-000D-12B4-321.11116/0000-000D-12B6-1