Zobrazeno 1 - 10
of 2 494
pro vyhledávání: '"Thomas, J J"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2024-2077 (2024)
Pyrazoles are rarely found in nature but are traditionally used in the agrochemical and pharmaceutical industries, while other areas of use are also actively developing. However, they have also found numerous other applications. The search for new an
Externí odkaz:
https://doaj.org/article/c4c8dfdcb1e64ce09a7f54cae8329d37
Autor:
Laura Schmitt, Julia Hoppe, Pablo Cea-Medina, Peter-Martin Bruch, Karina S. Krings, Ilka Lechtenberg, Daniel Drießen, Christoph Peter, Sanil Bhatia, Sascha Dietrich, Björn Stork, Gerhard Fritz, Holger Gohlke, Thomas J. J. Müller, Sebastian Wesselborg
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract A key feature of cancer is the disruption of cell cycle regulation, which is characterized by the selective and abnormal activation of cyclin-dependent kinases (CDKs). Consequently, targeting CDKs via meriolins represents an attractive thera
Externí odkaz:
https://doaj.org/article/63272546db6a4c5fbc60190ad36400b2
Autor:
Lukas Biesen, Thomas J. J. Müller
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Using the established synthetic methods, aroyl-S,N-ketene acetals and subsequent bi- and multichromophores can be readily synthesized. Aside from pronounced AIE (aggregation induced emission) properties, these selected examples possess disti
Externí odkaz:
https://doaj.org/article/d090e06815944dc880d3b920cd4bf86d
Autor:
Annabel Groenenberg, Lars Brouwers, Mike Bemelman, Thomas J. J. Maal, Jan M. M. Heyligers, Max M. Louwerse
Publikováno v:
BMC Digital Health, Vol 2, Iss 1, Pp 1-11 (2024)
Abstract Background Two-dimensional (2D) medical visualization techniques are often insufficient for displaying complex, three-dimensional (3D) anatomical structures. Moreover, the visualization of medical data on a 2D screen during surgery is undesi
Externí odkaz:
https://doaj.org/article/0efac23e42004952996e5dd29621164c
Autor:
Laura Schmitt, Ilka Lechtenberg, Daniel Drießen, Hector Flores-Romero, Margaretha A. Skowron, Marlena Sekeres, Julia Hoppe, Karina S. Krings, Tanya R. Llewellyn, Christoph Peter, Björn Stork, Nan Qin, Sanil Bhatia, Daniel Nettersheim, Gerhard Fritz, Ana J. García-Sáez, Thomas J. J. Müller, Sebastian Wesselborg
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Meriolin derivatives represent a new class of kinase inhibitors with a pronounced cytotoxic potential. Here, we investigated a newly synthesized meriolin derivative (termed meriolin 16) that displayed a strong apoptotic potential in Jurkat l
Externí odkaz:
https://doaj.org/article/bb0b5a2076ab4d3192f705aa5b86dbd2