Zobrazeno 1 - 10
of 435
pro vyhledávání: '"Thomas, Gudermann"'
Autor:
Maximilian Keck, Christian Hermann, Kyra Lützel, Thomas Gudermann, David B. Konrad, Michael Mederos y Schnitzler, Ursula Storch
Publikováno v:
iScience, Vol 27, Iss 10, Pp 111008- (2024)
Summary: The non-selective transient receptor potential canonical 6 (TRPC6) cation channels have several physiological and pathophysiological effects. They are activated by the lipid second messenger diacylglycerol (DAG) and by non-lipidic compounds
Externí odkaz:
https://doaj.org/article/14581ea90ce3437aadfb3f8c9ed4d86c
Autor:
Kirill D. Nadezhdin, Leonor Correia, Chamali Narangoda, Dhilon S. Patel, Arthur Neuberger, Thomas Gudermann, Maria G. Kurnikova, Vladimir Chubanov, Alexander I. Sobolevsky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The transient receptor potential channel TRPM7 is a master regulator of the organismal balance of divalent cations that plays an essential role in embryonic development, immune responses, cell mobility, proliferation, and differentiation. TR
Externí odkaz:
https://doaj.org/article/10950d54d07f4df59e7a501475b99298
Autor:
Francisco J. Rios, Zhi-Guo Zou, Adam P. Harvey, Katie Y. Harvey, Livia L. Camargo, Karla B. Neves, Sarah E. F. Nichol, Rheure Alves-Lopes, Alexius Cheah, Maram Zahraa, Alexey G. Ryazanov, Lillia Ryazanova, Thomas Gudermann, Vladimir Chubanov, Augusto C. Montezano, Rhian M. Touyz
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Deficiency of the Mg2+-permeable channel/α-kinase TRPM7 in mice increases susceptibility to cardiovascular and renal fibrosis induced by aldosterone and salt.
Externí odkaz:
https://doaj.org/article/cb2321b1b4554eefad7adf3bec82bdc7
Autor:
Noushafarin Khajavi, Andreas Beck, Klea Riçku, Philipp Beyerle, Katharina Jacob, Sabrina F. Syamsul, Anouar Belkacemi, Peter S. Reinach, Pascale C.F. Schreier, Houssein Salah, Tanja Popp, Aaron Novikoff, Andreas Breit, Vladimir Chubanov, Timo D. Müller, Susanna Zierler, Thomas Gudermann
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Most overweight individuals do not develop diabetes due to compensatory islet responses to restore glucose homeostasis. Therefore, regulatory pathways that promote β cell compensation are potential targets for treatment of diabetes. The transient re
Externí odkaz:
https://doaj.org/article/3e995b7dace7473fa3fc520fc567dc3c
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Galectins are carbohydrate-binding proteins that regulate many cellular functions including proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical evidence indicates that galectins influence many steps of cancer de
Externí odkaz:
https://doaj.org/article/09b507b7d0994ac7a291c72ec26bf62c
Autor:
Barbara Spix, Elisabeth S. Butz, Cheng-Chang Chen, Anna Scotto Rosato, Rachel Tang, Aicha Jeridi, Veronika Kudrina, Eva Plesch, Philipp Wartenberg, Elisabeth Arlt, Daria Briukhovetska, Meshal Ansari, Gizem Günes Günsel, Thomas M. Conlon, Amanda Wyatt, Sandra Wetzel, Daniel Teupser, Lesca M. Holdt, Fabien Ectors, Ingrid Boekhoff, Ulrich Boehm, Jaime García-Añoveros, Paul Saftig, Martin Giera, Sebastian Kobold, Herbert B. Schiller, Susanna Zierler, Thomas Gudermann, Christian Wahl-Schott, Franz Bracher, Ali Önder Yildirim, Martin Biel, Christian Grimm
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the l
Externí odkaz:
https://doaj.org/article/7d029bd581f74fcaa96bcacc1faef5b8
Autor:
Kathrin Malkmus, Monika Brosien, Fenja Knoepp, Lisa Schaffelhofer, Friedrich Grimminger, Christoph Rummel, Thomas Gudermann, Alexander Dietrich, Lutz Birnbaumer, Norbert Weissmann, Simone Kraut
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Chronic hypoxia-induced pulmonary hypertension (CHPH) is a severe disease that is characterized by increased proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) leading to pulmonary vascular remodeling. The resulting increa
Externí odkaz:
https://doaj.org/article/61661b96150f4e018e0f1ea791d97ae1
Autor:
Noushafarin Khajavi, Klea Riçku, Pascale C. F. Schreier, Tanja Gentz, Philipp Beyerle, Emmanuel Cruz, Andreas Breit, Peter S. Reinach, Thomas Gudermann
Publikováno v:
Cells, Vol 12, Iss 13, p 1790 (2023)
Magnesium is an essential mediator of a vast number of critical enzymatic cellular reactions in the human body. Some clinical epidemiological studies suggest that hypomagnesemia accounts for declines in insulin secretion in patients with type 2 diabe
Externí odkaz:
https://doaj.org/article/1a0ea34db118460cbd75b1d806b530a7
Autor:
Thirupura S. Shankar, Dinesh K. A. Ramadurai, Kira Steinhorst, Salah Sommakia, Rachit Badolia, Aspasia Thodou Krokidi, Dallen Calder, Sutip Navankasattusas, Paulina Sander, Oh Sung Kwon, Aishwarya Aravamudhan, Jing Ling, Andreas Dendorfer, Changmin Xie, Ohyun Kwon, Emily H. Y. Cheng, Kevin J. Whitehead, Thomas Gudermann, Russel S. Richardson, Frank B. Sachse, Johann Schredelseker, Kenneth W. Spitzer, Dipayan Chaudhuri, Stavros G. Drakos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart f
Externí odkaz:
https://doaj.org/article/5def0b8a41bf407088eed68a7df3942d
Autor:
Monika I. Hollenhorst, Rajender Nandigama, Saskia B. Evers, Igor Gamayun, Noran Abdel Wadood, Alaa Salah, Mario Pieper, Amanda Wyatt, Alexey Stukalov, Anna Gebhardt, Wiebke Nadolni, Wera Burow, Christian Herr, Christoph Beisswenger, Soumya Kusumakshi, Fabien Ectors, Tatjana I. Kichko, Lisa Hübner, Peter Reeh, Antje Munder, Sandra-Maria Wienhold, Martin Witzenrath, Robert Bals, Veit Flockerzi, Thomas Gudermann, Markus Bischoff, Peter Lipp, Susanna Zierler, Vladimir Chubanov, Andreas Pichlmair, Peter König, Ulrich Boehm, Gabriela Krasteva-Christ
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Constant exposure of the airways to inhaled pathogens requires efficient early immune responses protecting against infections. How bacteria on the epithelial surface are detected and first-line protective mechanisms are initiated are not well underst
Externí odkaz:
https://doaj.org/article/b6c462ddd8474b69bfe5c8500b0b830e