Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Thomas, Giller"'
Autor:
Frank Bühling, Joachim Richter, Susan H. Guttentag, Thilo Kähne, Klaus-Michael Müller, Nadine Kapp, Matthias Ochs, Thomas Giller, Georg Johnen, Matthew Derrick, Frank Brasch, Vesna Schauer-Vukasinovic, Samuel Hawgood
Publikováno v:
Journal of Biological Chemistry. 278:49006-49014
Surfactant protein B (SP-B) is a critical component of pulmonary surfactant, and a deficiency of active SP-B results in fatal respiratory failure. SP-B is synthesized by type-II pneumocytes as a 42-kDa propeptide (proSP-B), which is posttranslational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875cad1dafc089f4bc26c3c8704bd035
https://doi.org/10.1074/jbc.m306844200
https://doi.org/10.1074/jbc.m306844200
Autor:
Genevieve, Nguyen, Françoise, Delarue, Céline, Burcklé, Latifa, Bouzhir, Thomas, Giller, Jean-Daniel, Sraer
Publikováno v:
Journal of Clinical Investigation. 109:1417-1427
Renin is an aspartyl protease essential for the control of blood pressure and was long suspected to have cellular receptors. We report the expression cloning of the human renin receptor complementary DNA encoding a 350-amino acid protein with a singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d526a49ce60cdc11e9c022a6bb24ffd
https://doi.org/10.1172/jci0214276
https://doi.org/10.1172/jci0214276
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1524:51-56
Human napsin A is an aspartic proteinase highly expressed in kidney and lung. To elucidate whether napsin A is excreted in the urine we have performed an immunochemical study using anti-napsin A polyclonal antibody. As a result an immunoreactive band
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a2beb5a091e65e7ccfddb1d85b38fe
https://doi.org/10.1016/s0304-4165(00)00141-0
https://doi.org/10.1016/s0304-4165(00)00141-0
Autor:
Malcolm G. P. Page, Erich Kueng, and Peter Hunziker, Gérard Rossé, Thomas Giller, Daniel Schlatter, Hans-Werner Lahm, Vesna Schauer-Vukasinovic
Publikováno v:
Journal of Combinatorial Chemistry. 2:461-466
Fluorogenic substrates for assaying novel proteolytic enzymes could be rapidly identified using an easy, solid-phase combinatorial assay technology. The methodology was validated with leader peptidase of Escherichia coli using a subset of an intramol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa10bcd67e593094284d74f79188019a
https://doi.org/10.1021/cc000019y
https://doi.org/10.1021/cc000019y
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492:207-210
A full-length cDNA clone coding for rat napsin was identified by homology search of the ZooSeq rat EST database (Incyte). Northern blot analysis revealed high expression of napsin mRNA transcripts in kidney, lung and spleen. Western blot analysis sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c36c9ac281a29fa57099abfab53500
https://doi.org/10.1016/s0167-4781(00)00069-5
https://doi.org/10.1016/s0167-4781(00)00069-5
Autor:
Thomas Giller, Daniel Bur, Vesna Schauer-Vukasinovic, Gérard Rossé, Daniel Schlatter, Hans-Werner Lahm, Eric A. Kitas
Publikováno v:
European Journal of Biochemistry. 267:2573-2580
Recombinant human napsin A expressed in human embryonic kidney 293 cells was purified to homogeneity by a single-step procedure using part of napsin A propeptide as affinity ligand. N-Terminal amino-acid sequencing of the purified enzyme identified t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbe07d33d708d686afc95fba83efaeda
https://doi.org/10.1046/j.1432-1327.2000.01268.x
https://doi.org/10.1046/j.1432-1327.2000.01268.x
Publikováno v:
FEBS Letters. 462:135-139
A novel aspartic proteinase, called napsin, has recently been found in human and mouse. Due to high similarity with cathepsin D a structural model of human napsin A could be built. Based on this model a potential epitope SFYLNRDPEEPDGGE has been iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35922d541c383887fa40430ba67f5e8a
https://doi.org/10.1016/s0014-5793(99)01458-1
https://doi.org/10.1016/s0014-5793(99)01458-1
Autor:
Josiane De Caro, Thomas Giller, Frédéric Carrière, Robert Verger, Paola Barboni, Alain De Caro
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1387:331-341
Pancreatic lipase-related protein 1 (PLRP1) was purified from human, canine, porcine and rat pancreatic juices. The four PLRP1s were identified using microsequencing methods after performing gel filtration on Ultrogel AcA-54 followed by chromatograph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02509c41617d416081e395fb63b8bd4
https://doi.org/10.1016/s0167-4838(98)00143-5
https://doi.org/10.1016/s0167-4838(98)00143-5
Autor:
J. Grayson Richards, Volker Breu, Thomas Giller, Olivier Valdenaire, Anja Schweizer, Ali Ardati
Publikováno v:
FEBS Letters. 424:193-196
The cloning of a cDNA encoding a G protein-coupled receptor homologous to the endothelin type B receptor, but unable to bind endothelin, was recently reported and termed ETBR-LP. We report here the isolation of a human cDNA encoding a receptor that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e08021168ecdb409c0b2150673b6b080
https://doi.org/10.1016/s0014-5793(98)00170-7
https://doi.org/10.1016/s0014-5793(98)00170-7
Autor:
Uwe Klinkhammer, Volker Breu, Henri Ramuz, Werner Neidhart, Kaspar Burri, Thomas Giller, Martine Clozel, Georges Hirth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2223-2228
Implementation of a pyridylcarbamoyl group and an isopropylpyridylsulfonamide substituent as key components in the scaffold of Bosentan resulted in the identification of the potent orally active endothelin receptor antagonist Ro 48-5695. It shows aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03c8b1dff4ae40f218e7ffdbe573ab13
https://doi.org/10.1016/s0960-894x(97)00400-9
https://doi.org/10.1016/s0960-894x(97)00400-9