Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thomas, Gavin Hugh"'
Publikováno v:
Microbiology Society Annual Conference Online 2021 (ACO21)
Acyltransferase-3 (AT3) domain-containing proteins are involved in acylation of a diverse range of carbohydrates across all domains of life. In bacteria they are essential in processes including symbiosis, antimicrobial resistance, and antibiotic bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d71ede4346e30f5a750baeaa0d7e4d5
https://doi.org/10.1099/acmi.ac2021.po0309
https://doi.org/10.1099/acmi.ac2021.po0309
Akademický článek
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Autor:
Pearson, Caroline, Tindall, Sarah, Potts, Jennifer Robyn, Thomas, Gavin Hugh, Van Der Woude, Marjan
The acylation of sugars, most commonly via acetylation, is a widely used mechanism in bacteria that uses a simple chemical modification to confer useful traits. For structures like lipopolysaccharide, capsule and peptidoglycan, that function outside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::07b21ed8f85d0cccddfada23b98952c3
https://eprints.whiterose.ac.uk/185312/1/mic001146.pdf
https://eprints.whiterose.ac.uk/185312/1/mic001146.pdf
Autor:
Miller, Lisa Margaret, Simmons, Matt, Silver, Callum, Krauss, Thomas Fraser, Thomas, Gavin Hugh, Johnson, Steven David, Duhme-Klair, Anne-Kathrin
Antimicrobial resistance (AMR) continues to threaten the effective treatment and prevention of bacterial infections. The spread of resistant infections is accelerated by the lack of fast and cost-effective tests for the detection of AMR at the point-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::bf793e92495bad85aacecad8794a39db
https://eprints.whiterose.ac.uk/181626/1/d1na00635e.pdf
https://eprints.whiterose.ac.uk/181626/1/d1na00635e.pdf
Autor:
Miller, Lisa Margaret, Herman, Reyme, Gyulev, Ivan, Krauss, Thomas Fraser, Thomas, Gavin Hugh, Duhme-Klair, Anne-Kathrin
Molecular probes typically require structural modifications to allow for the immobilisation or bioconjugation with a desired substrate but the effects of these changes are often not evaluated. Here, we set out to determine the effects of attaching fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::6e456eeaa0c16bb6868168fdc8b76ce6
https://eprints.whiterose.ac.uk/166362/1/d0ra04893c.pdf
https://eprints.whiterose.ac.uk/166362/1/d0ra04893c.pdf
Autor:
Pearson, Caroline, Tindall, Sarah, Herman, Reyme, Jenkins, Huw Thomas, Bateman, Alex, Thomas, Gavin Hugh, Potts, Jennifer Robyn, Van Der Woude, Marjan
Membrane bound acyltransferase-3 (AT3) domain-containing proteins are implicated in a wide range of carbohydrate O-acyl modifications, but their mechanism of action is largely unknown. O-antigen acetylation by AT3 domain-containing acetyltransferases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::67729040fbeb90c74d4996bdc153096f
https://eprints.whiterose.ac.uk/163235/8/mBio_2020_Pearson_e01364_20.full.pdf
https://eprints.whiterose.ac.uk/163235/8/mBio_2020_Pearson_e01364_20.full.pdf
Autor:
Darby, John Fintan, Hopkins, Adam, Hubbard, Roderick Eliot, Roberts, Shirley M., Shimizu, Seishi, Brannigan, James A., Turkenburg, Johan, Thomas, Gavin Hugh, Fischer, Marcus
Solvent organization is a key but underexploited contributor to the thermodynamics of protein–ligand recognition, with implications for ligand discovery, drug resistance and protein engineering. Here, we explore the contribution of solvent to ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::10dce7b65b1fe9d7830a9f6a9fbe3712
https://eprints.whiterose.ac.uk/151301/1/20190725_JACS_revision_JDFinal.docx
https://eprints.whiterose.ac.uk/151301/1/20190725_JACS_revision_JDFinal.docx
Autor:
Miller, Lisa Margaret, Silver, Callum David, Herman, Reyme, Duhme-Klair, Anne-Kathrin, Thomas, Gavin Hugh, Krauss, Thomas Fraser, Johnson, Steven David
Antimicrobial resistance (AMR) has been identified as a major threat to public health worldwide. To ensure appropriate use of existing antibiotics, rapid and reliable tests of AMR are necessary. One of the most common and clinically important forms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::9675af59083558a1be7bc8b7a6751294
https://eprints.whiterose.ac.uk/150274/8/acsami.9b05793.pdf
https://eprints.whiterose.ac.uk/150274/8/acsami.9b05793.pdf