Výsledky vyhledávání - "Thomas, Endres"

Akademický článek

BDNF haploinsufficiency induces behavioral endophenotypes of schizophrenia in male mice that are rescued by enriched environment

Autor: Mahmoud Harb, Justina Jagusch, Archana Durairaja, Thomas Endres, Volkmar Leßmann, Markus Fendt

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Brain-derived neurotrophic factor (BDNF) is implicated in a number of processes that are crucial for healthy functioning of the brain. Schizophrenia is associated with low BDNF levels in the brain and blood, however, not much is known about

Externí odkaz: https://doaj.org/article/cf5edbc3e2ac4240b06e3c336327723b

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Repurposing drugs against Alzheimer’s disease: can the anti-multiple sclerosis drug fingolimod (FTY720) effectively tackle inflammation processes in AD?

Autor: Volkmar Leßmann, Georgia-Ioanna Kartalou, Thomas Endres, Marc Pawlitzki, Kurt Gottmann

Publikováno v: Journal of Neural Transmission.

Therapeutic approaches providing effective medication for Alzheimer’s disease (AD) patients after disease onset are urgently needed. Previous studies in AD mouse models and in humans suggested that physical exercise or changed lifestyle can delay A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40918c2a6a3db921de7da00d78a4a506
https://doi.org/10.1007/s00702-023-02618-5

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A Novel Aminomethacrylate-Based Copolymer for Solubility Enhancement—From Radical Polymer Synthesis to Manufacture and Characterization of Amorphous Solid Dispersions

Autor: Fabian-Pascal Schmied, Alexander Bernhardt, Christian Moers, Christian Meier, Thomas Endres, Sandra Klein

Publikováno v: Polymers; Volume 14; Issue 7; Pages: 1281

The present study covers the synthesis, purification and evaluation of a novel aminomethacrylate-based copolymer in terms of its suitability for improving the solubility and in vitro release of poorly water-soluble drug compounds. The new copolymer w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ac3d799431ec98b19608125259f89c

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Context and trade-offs characterize real-world threat detection systems: A review and comprehensive framework to improve research practice and resolve the translational crisis

Autor: Julia Sulger, Chris R. Dickman, Alexandra J. R. Carthey, Carsten T. Wotjak, Anke S. K. Frank, Michael H. Parsons, Thomas Endres, Markus Fendt, Miriam Schneider, Daniel T. Blumstein, Raimund Apfelbach, Menna E. Jones, Karin Roelofs, Yasushi Kiyokawa, Judith C. Kreutzmann, Daniel E. Heinz

Publikováno v: Neuroscience & Biobehavioral Reviews
Neuroscience and Biobehavioral Reviews, 115, 25-33
Neuroscience and Biobehavioral Reviews, 115, pp. 25-33

Contains fulltext : 219339.pdf (Publisher’s version ) (Closed access) A better understanding of context in decision-making - that is, the internal and external conditions that modulate decisions - is required to help bridge the gap between natural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc190d5a8ff2b9982e78bf3dc691aad
https://hdl.handle.net/2066/219339

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Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice

Autor: Robert Eckenstaler, Elke Edelmann, Thomas Endres, Tanja Brigadski, Klaus-Dieter Fischer, Beat Lutz, Karin Richter, Werner Zuschratter, Oliver Kobler, Julia Leschik, Thomas Munsch, Volkmar Lessmann

Publikováno v: Molecular Neurobiology. 56:6833-6855

Brain-derived neurotrophic factor (BDNF) is a secreted messenger molecule that is crucial for neuronal function and induction of synaptic plasticity. Although altered availability of BDNF underlies many neurological deficits and neurodegenerative dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8a12ad387b78a0cf71018e29da9706
https://doi.org/10.1007/s12035-019-1551-0

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ProBDNF Dependence of LTD and Fear Extinction Learning in the Amygdala of Adult Mice

Autor: Thomas Endres, Harish Vuyyuru, Thomas Munsch, Volkmar Lessmann, Xiaoyun Ma, Susanne Meis

Publikováno v: Cerebral cortex (New York, N.Y. : 1991). 32(7)

Neurotrophins are secreted proteins that control survival, differentiation, and synaptic plasticity. While mature neurotrophins regulate these functions via tyrosine kinase signaling (Trk), uncleaved pro-neurotrophins bind preferentially to the p75 n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2726140ef0692c1092aae0b4fba2f4af
https://pubmed.ncbi.nlm.nih.gov/34470044

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Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model

Autor: Hélène Marie, Eero Castrén, Ana R. Pereira, Plinio C. Casarotto, Georgia-Ioanna Kartalou, Thomas Endres, Angelina Lesnikova, Volkmar Lessmann, Paula A. Pousinha, Kurt Gottmann, Kevin Delanoe, Elke Edelmann

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, ⟨10.3390/ijms21238957⟩
bioRxiv

Therapeutical approaches providing effective medication for Alzheimer’s disease (AD) patients after disease onset are urgently needed. Repurposing FDA approved drugs like fingolimod (FTY720) for treatment of AD is a promising way to reduce the time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5eeda3df9662b5a3ef1da9542c1866
https://hal.archives-ouvertes.fr/hal-03017159/file/Title_Anti-inflammatory_treatment_with_FTY720_star.pdf

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The Relation Between Long-Term Synaptic Plasticity at Glutamatergic Synapses in the Amygdala and Fear Learning in Adult Heterozygous BDNF-Knockout Mice

Autor: Thomas Endres, Volkmar Lessmann, Thomas Munsch, Susanne Meis

Publikováno v: Cerebral Cortex. 28:1195-1208

Brain-derived neurotrophic factor (BDNF) heterozygous knockout mice (BDNF+/- mice) show fear learning deficits from 3 months of age onwards. Here, we addressed the question how this learning deficit correlates with altered long-term potentiation (LTP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efed4a6234296f6258ccfedb0a547e8a
https://doi.org/10.1093/cercor/bhx032

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