Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Thomas, Edwards"'
Autor:
Fabrice E. Graf, Richard N. Goodman, Sarah Gallichan, Sally Forrest, Esther Picton-Barlow, Alice J. Fraser, Minh-Duy Phan, Madalitso Mphasa, Alasdair T. M. Hubbard, Patrick Musicha, Mark A. Schembri, Adam P. Roberts, Thomas Edwards, Joseph M. Lewis, Nicholas A. Feasey
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Infections with Enterobacterales (E) are increasingly difficult to treat due to antimicrobial resistance. After ceftriaxone replaced chloramphenicol (CHL) as empiric therapy for suspected sepsis in Malawi in 2004, extended-spectrum beta-lact
Externí odkaz:
https://doaj.org/article/a653d1fed48c4d248ed8875692a5b104
Autor:
Usa Boonyuen, Beatriz Aira C. Jacob, Jutamas Wongwigkan, Kamonwan Chamchoy, Natsamon Singha-art, Natnicha Pengsuk, Duantida Songdej, Emily R. Adams, Thomas Edwards, Supat Chamnanchanunt, Syazwani Itri Amran, Nurriza Ab Latif, Naveen Eugene Louis, Shamini Chandran
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background It was hypothesized that glucose-6-phosphate dehydrogenase (G6PD) deficiency confers a protective effect against malaria infection, however, safety concerns have been raised regarding haemolytic toxicity caused by radical cure wit
Externí odkaz:
https://doaj.org/article/8d6ac690322f4154b192ebeed6d537c9
Autor:
Kieran Collings, Cedric Boisdon, Tung-Ting Sham, Kevin Skinley, Hyun-Kyung Oh, Tessa Prince, Adham Ahmed, Shaun H. Pennington, Philip J. Brownridge, Thomas Edwards, Giancarlo A. Biagini, Claire E. Eyers, Amanda Lamb, Peter Myers, Simon Maher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The novel coronavirus pandemic (COVID-19) has necessitated a global increase in the use of face masks to limit the airborne spread of the virus. The global demand for personal protective equipment has at times led to shortages of face masks
Externí odkaz:
https://doaj.org/article/409957c3687e47d9895926e953749aae
Autor:
Alice J. Fraser, Caitlin Greenland-Bews, Daniel Kelly, Christopher T. Williams, LSTM Diagnostics Group, CONDOR Steering Group, Richard Body, Emily R. Adams, Ana Cubas Atienzar, Thomas Edwards, David J. Allen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The emergence of severe acute respiratory syndrome 2 (SARS-CoV-2) variants of concern (VOCs), with mutations linked to increased transmissibility, vaccine escape and virulence, has necessitated the widespread genomic surveillance of SARS-CoV
Externí odkaz:
https://doaj.org/article/c1bd2a7b2fb246349be8342813486c5c
Autor:
Caitlin Greenland-Bews, Rachel L. Byrne, Sophie I. Owen, Rachel L. Watkins, Daisy Bengey, Kate Buist, Karina Clerkin, Camille Escadafal, Lorna S. Finch, Susan Gould, Emanuele Giorgi, Andy Hodgkinson, Larysa Mashenko, Darren Powell, Helen R. Savage, Caitlin R. Thompson, Lance Turtle, Jahanara Wardale, Dominic Wooding, Thomas Edwards, Ana Cubas Atienzar, Emily R. Adams
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background Rapid determination of an individual’s antibody status can be beneficial in understanding an individual’s immune response to SARS-CoV-2 and for initiation of therapies that are only deemed effective in sero-negative individual
Externí odkaz:
https://doaj.org/article/98c74c74a31a4488879b6a6d9ad46289
Autor:
Thomas Edwards, Christopher T. Williams, Macrine Olwala, Pauline Andang’o, Walter Otieno, Grace N. Nalwa, Abimbola Akindolire, Ana I. Cubas-Atienzar, Toby Ross, Olukemi O. Tongo, Emily R. Adams, Helen Nabwera, Stephen Allen
Publikováno v:
Antimicrobial Resistance and Infection Control, Vol 12, Iss 1, Pp 1-8 (2023)
Abstract Objectives Neonatal sepsis, a major cause of death amongst infants in sub-Saharan Africa, is often gut derived. Gut colonisation by Enterobacteriaceae producing extended spectrum beta-lactamase (ESBL) or carbapenemase enzymes can lead to ant
Externí odkaz:
https://doaj.org/article/7bd8064a20944f1f9fe511f56ad506a9
Autor:
I’ah Donovan-Banfield, Rebekah Penrice-Randal, Hannah Goldswain, Aleksandra M. Rzeszutek, Jack Pilgrim, Katie Bullock, Geoffrey Saunders, Josh Northey, Xiaofeng Dong, Yan Ryan, Helen Reynolds, Michelle Tetlow, Lauren E. Walker, Richard FitzGerald, Colin Hale, Rebecca Lyon, Christie Woods, Shazaad Ahmad, Dennis Hadjiyiannakis, Jimstan Periselneris, Emma Knox, Calley Middleton, Lara Lavelle-Langham, Victoria Shaw, William Greenhalf, Thomas Edwards, David G. Lalloo, Christopher J. Edwards, Alistair C. Darby, Miles W. Carroll, Gareth Griffiths, Saye H. Khoo, Julian A. Hiscox, Thomas Fletcher
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Molnupiravir is an antiviral that forces lethal error catastrophe in SARS-CoV-2 RNAs. Here, the authors confirm the mechanism of action of molnupiravir in humans using samples obtained from the UK’s AGILE phase IIa clinical trial investigating the
Externí odkaz:
https://doaj.org/article/ce55d33708154cc1b4167b313d922661
Autor:
Prakash Ghosh, Rajashree Chowdhury, Shomik Maruf, Albert Picado, Faria Hossain, Sophie I. Owen, Rupen Nath, James Baker, Md Golam Hasnain, Mohammad Sohel Shomik, Debashis Ghosh, Masud Rashid, Md. Utba Rashid, Soumik Kha Sagar, Md. Abu Rahat, Ariful Basher, Proggananda Nath, Thomas Edwards, Jason R. Andrews, Malcolm S. Duthie, Dziedzom K. de Souza, Emily R. Adams, Joseph Ndungu, Israel Cruz, Dinesh Mondal
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Despite the availability of highly sensitive polymerase chain reaction (PCR)-based methods, the dearth of remotely deployable diagnostic tools circumvents the early and accurate detection of individuals with post-kala-azar dermal leishmanias
Externí odkaz:
https://doaj.org/article/f31fb3e5b569485ea1860d9ea3cf23bc
Autor:
Rebecca Lester, Melodie Sammarro, Christopher P. Jewell, Derek Cocker, Nicola Elviss, Kondwani Chidziwisano, Henry Kajumbula, Shevin T. Jacob, David Musoke, Lawrence Mugisha, Barry Rowlingson, Patrick Musicha, Beth Hollihead, Rachel L. Byrne, Catherine N. Wilson, Tracy Morse, Nicholas R. Thomson, Thomas Edwards, Nicholas A. Feasey, Andrew C. Singer, Adam P. Roberts
Publikováno v:
Wellcome Open Research, Vol 7 (2023)
In sub-Saharan Africa (sSA), there is high morbidity and mortality from severe bacterial infection and this is compounded by antimicrobial resistance, in particular, resistance to 3rd-generation cephalosporins. This resistance is typically mediated b
Externí odkaz:
https://doaj.org/article/79aafd2121c84f58b147b0f9725c0d26