Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Thomas, Durek"'
Autor:
Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, o
Externí odkaz:
https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801
Publikováno v:
Molecules, Vol 28, Iss 7, p 3189 (2023)
Bioactive peptides are a highly abundant and diverse group of molecules that exhibit a wide range of structural and functional variation. Despite their immense therapeutic potential, bioactive peptides have been traditionally perceived as poor drug c
Externí odkaz:
https://doaj.org/article/93a1f8c1e1b74194b60f70dbf34e4b99
Autor:
Junqiao Du, Kuok Yap, Lai Yue Chan, Fabian B. H. Rehm, Fong Yang Looi, Aaron G. Poth, Edward K. Gilding, Quentin Kaas, Thomas Durek, David J. Craik
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Asparaginyl endopeptidases (AEPs) catalyze the cyclization step during the biosynthesis of cyclic peptides in plants. Here, the authors report a recombinantly produced AEP that catalyzes the backbone cyclization of a linear cyclotide precursor and an
Externí odkaz:
https://doaj.org/article/2374d960c8e2417095bdec822494ebdd
Autor:
Aaron G. Poth, Francis C.K. Chiu, Sofie Stalmans, Brett R. Hamilton, Yen-Hua Huang, David M. Shackleford, Rahul Patil, Thao T. Le, Meng-Wei Kan, Thomas Durek, Evelien Wynendaele, Bart De Spiegeleer, Andrew K. Powell, Deon J. Venter, Richard J. Clark, Susan A. Charman, David J. Craik
Publikováno v:
Medicine in Drug Discovery, Vol 10, Iss , Pp 100087- (2021)
Chronic pain is an undertreated epidemic affecting quality of life in at least 20% of the global population, and CNS-related side effects, tolerance, and addiction are common features of current medications. α-Conotoxin Vc1.1 potently elicits prolon
Externí odkaz:
https://doaj.org/article/e60af3d636f34e9cace11a1df3b3f934
Autor:
Sixin Tian, Thomas Durek, Conan K. Wang, Christina N. Zdenek, Bryan G. Fry, David J. Craik, Simon J. de Veer
Publikováno v:
Journal of Medicinal Chemistry. 65:15698-15709
Factor XIIa (FXIIa) is a promising target for developing new drugs that prevent thrombosis without causing bleeding complications. A native cyclotide (MCoTI-II) is gaining interest for engineering FXIIa-targeted anticoagulants as this peptide inhibit
Autor:
Yan Zhou, Peta J. Harvey, Johannes Koehbach, Lai Yue Chan, Alun Jones, Åsa Andersson, Irina Vetter, Thomas Durek, David J. Craik
Publikováno v:
Angewandte Chemie International Edition.
Autor:
Joshua S. Wingerd, Christine A. Mozar, Christine A. Ussing, Swetha S. Murali, Yanni K.-Y. Chin, Ben Cristofori-Armstrong, Thomas Durek, John Gilchrist, Christopher W. Vaughan, Frank Bosmans, David J. Adams, Richard J. Lewis, Paul F. Alewood, Mehdi Mobli, Macdonald J. Christie, Lachlan D. Rash
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Voltage-gated sodium (NaV) channels are essential for the transmission of pain signals in humans making them prime targets for the development of new analgesics. Spider venoms are a rich source of peptide modulators useful to study ion chann
Externí odkaz:
https://doaj.org/article/f33655e710d64fada2b711f3a0de8577
Autor:
Mark A. Jackson, Kuok Yap, Aaron G. Poth, Edward K. Gilding, Joakim E. Swedberg, Simon Poon, Haiou Qu, Thomas Durek, Karen Harris, Marilyn A. Anderson, David J. Craik
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
The backbone cyclic and disulfide bridged sunflower trypsin inhibitor-1 (SFTI-1) peptide is a proven effective scaffold for a range of peptide therapeutics. For production at laboratory scale, solid phase peptide synthesis techniques are widely used,
Externí odkaz:
https://doaj.org/article/1cf8e40b56734239a099631164e722fb
Autor:
Marilyn A. Anderson, Nicole L. van der Weerden, David J. Craik, Karen S. Harris, Thomas Durek, Mark A. Jackson, Owen C. McCorkelle, Edward K. Gilding, Simon Poon
Publikováno v:
Journal of Experimental Botany
Backbone-cyclized peptides, which have applications in the pharmaceutical and agricultural industries, can be made efficiently in plants by co-expressing them with a cyclizing enzyme.
Cyclotides are ultra-stable, backbone-cyclized plant defence
Cyclotides are ultra-stable, backbone-cyclized plant defence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2ce567b261338377293a2ad4deb082
Autor:
Valentin Jakob, Ben G.E. Zoller, Julia Rinkes, Yingwen Wu, Alexander F. Kiefer, Michael Hust, Saskia Polten, Andrew M. White, Peta J. Harvey, Thomas Durek, David J. Craik, Andreas Siebert, Uli Kazmaier, Martin Empting
Small macrocyclic peptides are promising candidates for new anti-infective drugs. To date, such peptides have been poorly studied in the context of anti-virulence targets. Using phage display and a self-designed peptide library, we identified a cycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e738afb2fdc11b9e7e791db3ccd0a1b