Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Thomas, Dugé de Bernonville"'
Autor:
Emily Amor Stander, Beata Lehka, Inês Carqueijeiro, Clément Cuello, Frederik G. Hansson, Hans J. Jansen, Thomas Dugé De Bernonville, Caroline Birer Williams, Valentin Vergès, Enzo Lezin, Marcus Daniel Brandbjerg Bohn Lorensen, Thu-Thuy Dang, Audrey Oudin, Arnaud Lanoue, Mickael Durand, Nathalie Giglioli-Guivarc’h, Christian Janfelt, Nicolas Papon, Ron P. Dirks, Sarah Ellen O’connor, Michael Krogh Jensen, Sébastien Besseau, Vincent Courdavault
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
Abstract Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized metabolites mainly produced in Gentianales to cope with environmental challenges. Due to their pharmacological properties, the biosynthetic modalities of se
Externí odkaz:
https://doaj.org/article/60239ee0c7994813904a74c32f5c4947
Autor:
Sarah Ellen O'Connor, Sébastien Besseau, Ron P. Dirks, Michael Krogh Jensen, Arnaud Lanoue, Nathalie Giglioli Guivarc'h, Audrey Oudin, Caroline Birer Williams, Hans J. Jansen, Thomas Dugé De Bernonville, Clément Cuello, Emily Amor Stander, Nicolas Papon, Vincent Courdavault
Publikováno v:
F1000Research, Vol 11 (2022)
The Madagascar periwinkle, Catharanthus roseus, belongs to the Apocynaceae family. This medicinal plant, endemic to Madagascar, produces many important drugs including the monoterpene indole alkaloids (MIA) vincristine and vinblastine used to treat c
Externí odkaz:
https://doaj.org/article/fd8bb44b1ec54c25a59a9cf3f78f3281
Autor:
Kévin Billet, Sébastien Salvador-Blanes, Thomas Dugé De Bernonville, Guillaume Delanoue, Florent Hinschberger, Audrey Oudin, Vincent Courdavault, Olivier Pichon, Sébastien Besseau, Samuel Leturcq, Nathalie Giglioli-Guivarc’h, Arnaud Lanoue
Publikováno v:
Molecules, Vol 28, Iss 11, p 4555 (2023)
The composition of bioactive polyphenols from grape canes, an important viticultural byproduct, was shown to be varietal-dependent; however, the influence of soil-related terroir factors remains unexplored. Using spatial metabolomics and correlation-
Externí odkaz:
https://doaj.org/article/1e8e87803c094683af7be05febb27167
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3659-3663 (2021)
Camptothecin is a clinically important monoterpene indole alkaloid (MIAs) used for treating various cancers. Currently, the production of this biopharmaceutical hinges on its extraction from camptothecin-producing plants, leading to high market price
Externí odkaz:
https://doaj.org/article/602141624b9b47bcb08981d35f85c82f
Autor:
Patrick Vandeputte, Thomas Dugé de Bernonville, Yohann Le Govic, Solène Le Gal, Gilles Nevez, Nicolas Papon, Jean-Philippe Bouchara
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3468-3483 (2020)
Scedosporium species rank second among the filamentous fungi colonizing the lungs of patients with cystic fibrosis (CF). Apart from the context of immunodeficiency (lung transplantation), the colonization of the CF airways by these fungi usually rema
Externí odkaz:
https://doaj.org/article/8b2fb45d469e491999b18afe9a9e0b91
Autor:
Sylvaine Renault, Murielle Genty, Alison Gabori, Catherine Boisneau, Charles Esnault, Thomas Dugé de Bernonville, Corinne Augé-Gouillou
Publikováno v:
BMC Genetics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Both classes of transposable elements (DNA and RNA) are tightly regulated at the transcriptional level leading to the inactivation of transposition via epigenetic mechanisms. Due to the high copies number of these elements, the hy
Externí odkaz:
https://doaj.org/article/26614a590ed24b41847450e0f15e5047
Autor:
Lanoue, Kévin Billet, Sébastien Salvador-Blanes, Thomas Dugé De Bernonville, Guillaume Delanoue, Florent Hinschberger, Audrey Oudin, Vincent Courdavault, Olivier Pichon, Sébastien Besseau, Samuel Leturcq, Nathalie Giglioli-Guivarc’h, Arnaud
Publikováno v:
Molecules; Volume 28; Issue 11; Pages: 4555
The composition of bioactive polyphenols from grape canes, an important viticultural byproduct, was shown to be varietal-dependent; however, the influence of soil-related terroir factors remains unexplored. Using spatial metabolomics and correlation-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::3c76ca4813bf1d0ccb78258fec5fb928
Autor:
Evangelos C. Tatsis, Inês Carqueijeiro, Thomas Dugé de Bernonville, Jakob Franke, Thu-Thuy T. Dang, Audrey Oudin, Arnaud Lanoue, Florent Lafontaine, Anna K. Stavrinides, Marc Clastre, Vincent Courdavault, Sarah E. O’Connor
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The biosynthetic pathway of preakuammicine, a monoterpene precursor of the anti-cancer agent vinblastine, has remained largely unexplored. Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem, convert
Externí odkaz:
https://doaj.org/article/03bb68418f55480082f388e21cdaf80b
Autor:
Emily Amor Stander, Liuda Johana Sepúlveda, Thomas Dugé de Bernonville, Inês Carqueijeiro, Konstantinos Koudounas, Pamela Lemos Cruz, Sébastien Besseau, Arnaud Lanoue, Nicolas Papon, Nathalie Giglioli-Guivarc’h, Ron Dirks, Sarah Ellen O’Connor, Lucia Atehortùa, Audrey Oudin, Vincent Courdavault
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1595 (2020)
The lesser periwinkle Vinca minor accumulates numerous monoterpene indole alkaloids (MIAs) including the vasodilator vincamine. While the biosynthetic pathway of MIAs has been largely elucidated in other Apocynaceae such as Catharanthus roseus, the c
Externí odkaz:
https://doaj.org/article/b8374e5797594eed9a42d3fa2806a3ea
Autor:
Thomas Dugé de Bernonville, Stéphane Maury, Alain Delaunay, Christian Daviaud, Cristian Chaparro, Jörg Tost, Sarah Ellen O’Connor, Vincent Courdavault
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6028 (2020)
Catharanthus roseus produces a wide spectrum of monoterpene indole alkaloids (MIAs). MIA biosynthesis requires a tightly coordinated pathway involving more than 30 enzymatic steps that are spatio-temporally and environmentally regulated so that some
Externí odkaz:
https://doaj.org/article/614c156af11f497e8a571fe10398f054