Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Thomas, Drivsholm"'
Autor:
Henna Cederberg, Imre Pavo, Torben Hansen, Allan Linneberg, Harshal Deshmukh, Mark I. McCarthy, Mark Walker, Andrew R. Wood, Anne Lundager Madsen, Andrea Mari, Hartmut Ruetten, Federico De Masi, Robert W. Koivula, Alison Heggie, Niels Grarup, Angus G. Jones, Thorkild I. A. Sørensen, Konstantinos K. Tsirigos, Christian Theil Have, Markku Laakso, Arne Astrup, Ele Ferrannini, Paul W. Franks, Andrea Tura, Ewan R. Pearson, Oluf Pedersen, Femke Rutters, Ana Viñuela, Martin Ridderstråle, Anitra D.M. Koopman, Anette A. P. Gjesing, Anubha Mahajan, Timothy M. Frayling, Thomas Drivsholm
Publikováno v:
Deshmukh, H A, Madsen, A L, Viñuela, A, Have, C T, Grarup, N, Tura, A, Mahajan, A, Heggie, A J, Koivula, R W, De Masi, F, Tsirigos, K K, Linneberg, A, Drivsholm, T, Pedersen, O, Sørensen, T I A, Astrup, A, Gjesing, A A P, Pavo, I, Wood, A R, Ruetten, H, Jones, A G, Koopman, A D M, Cederberg, H, Rutters, F, Ridderstrale, M, Laakso, M, McCarthy, M I, Frayling, T M, Ferrannini, E, Franks, P W, Pearson, E R, Mari, A, Hansen, T & Walker, M 2020, ' Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity ', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 1, pp. 80-90 . https://doi.org/10.1210/clinem/dgaa653
The Journal of clinical endocrinology and metabolism, 106(1), 80-90. The Endocrine Society
Deshmukh, H A, Madsen, A L, Viñuela, A, Have, C T, Grarup, N, Tura, A, Mahajan, A, Heggie, A J, Koivula, R W, de Masi, F, Tsirigos, K K, Linneberg, A, Drivsholm, T, Pedersen, O, Sørensen, T I A, Astrup, A, Gjesing, A A P, Pavo, I, Wood, A R, Ruetten, H, Jones, A G, Koopman, A D M, Cederberg, H, Rutters, F, Ridderstrale, M, Laakso, M, McCarthy, M I, Frayling, T M, Ferrannini, E, Franks, P W, Pearson, E R, Mari, A, Hansen, T & Walker, M 2021, ' Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity ', The Journal of clinical endocrinology and metabolism, vol. 106, no. 1, pp. 80-90 . https://doi.org/10.1210/clinem/dgaa653, https://doi.org/10.1210/clinem/dgaa653
Deshmukh, H A, Madsen, A L, Viñuela, A, Have, C T, Grarup, N, Tura, A, Mahajan, A, Heggie, A J, Koivula, R W, De Masi, F, Tsirigos, K K, Linneberg, A, Drivsholm, T, Pedersen, O, Sørensen, T I A, Astrup, A, Gjesing, A A P, Pavo, I, Wood, A R, Ruetten, H, Jones, A G, Koopman, A D M, Cederberg, H, Rutters, F, Ridderstrale, M, Laakso, M, McCarthy, M I, Frayling, T M, Ferrannini, E, Franks, P W, Pearson, E R, Mari, A, Hansen, T & Walker, M 2021, ' Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity ', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 1, pp. 80-90 . https://doi.org/10.1210/clinem/dgaa653
The Journal of clinical endocrinology and metabolism, 106(1), 80-90. The Endocrine Society
Deshmukh, H A, Madsen, A L, Viñuela, A, Have, C T, Grarup, N, Tura, A, Mahajan, A, Heggie, A J, Koivula, R W, de Masi, F, Tsirigos, K K, Linneberg, A, Drivsholm, T, Pedersen, O, Sørensen, T I A, Astrup, A, Gjesing, A A P, Pavo, I, Wood, A R, Ruetten, H, Jones, A G, Koopman, A D M, Cederberg, H, Rutters, F, Ridderstrale, M, Laakso, M, McCarthy, M I, Frayling, T M, Ferrannini, E, Franks, P W, Pearson, E R, Mari, A, Hansen, T & Walker, M 2021, ' Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity ', The Journal of clinical endocrinology and metabolism, vol. 106, no. 1, pp. 80-90 . https://doi.org/10.1210/clinem/dgaa653, https://doi.org/10.1210/clinem/dgaa653
Deshmukh, H A, Madsen, A L, Viñuela, A, Have, C T, Grarup, N, Tura, A, Mahajan, A, Heggie, A J, Koivula, R W, De Masi, F, Tsirigos, K K, Linneberg, A, Drivsholm, T, Pedersen, O, Sørensen, T I A, Astrup, A, Gjesing, A A P, Pavo, I, Wood, A R, Ruetten, H, Jones, A G, Koopman, A D M, Cederberg, H, Rutters, F, Ridderstrale, M, Laakso, M, McCarthy, M I, Frayling, T M, Ferrannini, E, Franks, P W, Pearson, E R, Mari, A, Hansen, T & Walker, M 2021, ' Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity ', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 1, pp. 80-90 . https://doi.org/10.1210/clinem/dgaa653
Context Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95270ab3a5ca8c9691da3ac064d3489
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180264
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180264
Autor:
Torben Hansen, Thea Skaaby, Daniel R. Witte, Henrik Vestergaard, Allan Linneberg, Oluf Pedersen, Marit E. Jørgensen, Louise Lundby-Christensen, Thomas Drivsholm, Niels Grarup, Theresia M. Schnurr, Line Engelbrechtsen, Vincent E Appel
Publikováno v:
Engelbrechtsen, L, Appel, V E, Schnurr, T M, Lundby-Christensen, L, Skaaby, T, Linneberg, A, Drivsholm, T, Witte, D R, Jorgensen, M E, Grarup, N, Pedersen, O, Hansen, T, Vestergaard, H & The CIMT Trial Group 2019, ' Genetic determinants of blood pressure traits are associated with carotid arterial thickening and plaque formation in patients with type 2 diabetes ', Diabetes and Vascular Disease Research, vol. 16, no. 1, pp. 13-21 . https://doi.org/10.1177/1479164118810365
CIMT Trial Group 10 (Daniel Witte; member) 2019, ' Genetic determinants of blood pressure traits are associated with carotid arterial thickening and plaque formation in patients with type 2 diabetes ', Diabetes and Vascular Disease Research, vol. 16, no. 1, pp. 13-21 . https://doi.org/10.1177/1479164118810365
CIMT Trial Group 10 (Daniel Witte; member) 2019, ' Genetic determinants of blood pressure traits are associated with carotid arterial thickening and plaque formation in patients with type 2 diabetes ', Diabetes and Vascular Disease Research, vol. 16, no. 1, pp. 13-21 . https://doi.org/10.1177/1479164118810365
OBJECTIVES: The aim of this study is to explore the contribution of genetically driven cardiometabolic risk factors for development of carotid arterial thickening in patients with type 2 diabetes.METHODS: In total, 12 genetic risk scores for blood pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ec6776c8f8213e25dddef43259604e
https://pure.au.dk/portal/da/publications/genetic-determinants-of-blood-pressure-traits-are-associated-with-carotid-arterial-thickening-and-plaque-formation-in-patients-with-type-2-diabetes(dc9f37f3-f91a-4d37-a252-660ad6072514).html
https://pure.au.dk/portal/da/publications/genetic-determinants-of-blood-pressure-traits-are-associated-with-carotid-arterial-thickening-and-plaque-formation-in-patients-with-type-2-diabetes(dc9f37f3-f91a-4d37-a252-660ad6072514).html
Autor:
Charlotte Glümer, C. S. Rose, Torben Jørgensen, S. K. Torekov, Knut Borch-Johnsen, Claus Thorn Ekstrøm, Anette P. Gjesing, D. P. Jensen, Søren A. Urhammer, Oluf Pedersen, Torben Hansen, Søren K. Rasmussen, Gregers S. Andersen, Thomas Drivsholm, S. K. Hansen, Mark I. McCarthy
AIMS/HYPOTHESIS: The class III allele of the variable-number-of-tandem-repeats polymorphism located 5' of the insulin gene (INS-VNTR) has been associated with Type 2 diabetes and altered birthweight. It has also been suggested, although inconsistentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3027ef5928b8bf368eacf53c397af9
https://doi.org/10.1007/s00125-004-1418-3
https://doi.org/10.1007/s00125-004-1418-3
Autor:
Grith Lykke Sørensen, Rudi Steffensen, Else-Marie Bladbjerg, Jens Madsen, Thomas Drivsholm, Uffe Holmskov, Qihua Tan
Publikováno v:
Sorensen, G L, Bladbjerg, E M, Steffensen, R, Tan, Q, Madsen, J, Drivsholm, T & Holmskov, U 2016, ' Association between the surfactant protein D (SFTPD) gene and subclinical carotid artery atherosclerosis ', Atherosclerosis, vol. 246, pp. 7-12 . https://doi.org/10.1016/j.atherosclerosis.2015.12.037
Sorensen, G L, Bladbjerg, E M, Steffensen, R, Tan, Q, Madsen, J, Drivsholm, T & Holmskov, U 2016, ' Association between the surfactant protein D ( SFTPD ) gene and subclinical carotid artery atherosclerosis ', Atherosclerosis, vol. 246, pp. 7-12 . https://doi.org/10.1016/j.atherosclerosis.2015.12.037
Sorensen, G L, Bladbjerg, E M, Steffensen, R, Tan, Q, Madsen, J, Drivsholm, T & Holmskov, U 2016, ' Association between the surfactant protein D ( SFTPD ) gene and subclinical carotid artery atherosclerosis ', Atherosclerosis, vol. 246, pp. 7-12 . https://doi.org/10.1016/j.atherosclerosis.2015.12.037
Objective Surfactant protein D (SP-D) is a defense collectin with inflammation-modulating properties. SP-D deficiency inhibits atherosclerosis in vivo , and the circulatory SP-D levels have been previously associated with cardiovascular disease morta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c508c8ad56f9d1f7edf12dc524755e4
https://vbn.aau.dk/da/publications/993453d8-68d5-4f5e-b624-65d1185f2822
https://vbn.aau.dk/da/publications/993453d8-68d5-4f5e-b624-65d1185f2822
Autor:
Volkert Siersma, Thomas Drivsholm, Niels de Fine Olivarius, Beatrice Dyring-Andersen, Jan Erik Henriksen, Lars J. Hansen
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 108:285-288
Chronic exposure to glucocorticoids (GCs) has many side effects including glucose intolerance and diabetes and may accelerate the occurrence of cardiovascular disease and increase mortality. We studied the 14-year clinical development of diabetes in
Autor:
Oluf Pedersen, Thomas Drivsholm, Torben Hansen, Rene T. Palacios, Søren A. Urhammer, Knut Borch-Johnsen, Aage Vølund
Publikováno v:
Diabetes Care. 30:257-262
OBJECTIVE—Insulin resistance and impaired β-cell function are key elements in the pathogenesis of type 2 diabetes. We aimed to develop valid algorithms for estimation of the insulin sensitivity index (SI) and acute insulin response (AIR) derived f
Autor:
Torben Jørgensen, K Yanagisawa, Charlotte Glümer, C S Rose, Thomas Drivsholm, B M Spiegelman, Oluf Pedersen, T. Hansen, Jiachen Lin, Gregers S. Andersen, L Wegner, Knut Borch-Johnsen
Publikováno v:
Journal of Medical Genetics. 42:402-407
Background: Peroxisome proliferator activated receptor-γ coactivator-1β (PGC-1β) is a recently identified homologue of the tissue specific coactivator PGC-1α, a coactivator of transcription factors such as the peroxisome proliferators activated r
Autor:
Eva-Maria D. Nielsen, Allan Vaag, Charlotte Glümer, Lise Tarnow, Lise Wegner, Peter Mouritzen, Thomas Drivsholm, Torben Jørgensen, Gitte Andersen, D. P. Jensen, Jakob Ek, Hans-Henrik Parving, S. K. Hansen, Torben Hansen, Pernille Poulsen, Oluf Pedersen, Knut Borch-Johnsen
Publikováno v:
Hypertension. 45:565-570
PGC-1α is a coactivator of numerous transcription factors and is expressed in tissues with high energy demands and abundant in mitochondria. It is induced in the myocardium on fasting and physical exercise, and cardiac-specific overexpression stimul
Autor:
Anders Johansen, Jakob Ek, Oluf Pedersen, Kevin Larade, C. S. Rose, Torben Hansen, Peter Damm, Knut Borch-Johnsen, Jianxin Xie, Lise Wegner, Jeannet Lauenborg, Gitte Andersen, H. Franklin Bunn, Thomas Drivsholm, Hao Zhu
Publikováno v:
Diabetes. 53:2992-2997
Recent data show that homozygous Ncb5or−/− knock-out mice present with an early-onset nonautoimmune diabetes phenotype. Furthermore, genome-wide scans have reported linkage to the chromosome 6q14.2 region close to the human NCB5OR. We therefore c
Autor:
Torben Hansen, Gitte Andersen, Lesli H. Larsen, Thomas Drivsholm, Nanni Din, Teis Andersen, Thorkild I. A. Sørensen, Oluf Pedersen, Knut Borch-Johnsen, Louise Torp Dalgaard, Jan Fleckner
Publikováno v:
Obesity Research. 11:1420-1427
Objective: To identify polymorphisms in the human uncoupling protein 2 gene (UCP2) promoter and to investigate whether these were associated with obesity or weight gain. Research Methods and Procedures: The human UCP2 promoter was characterized by re