Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Thomas, Dobner"'
Autor:
Wing-Hang Ip, Marie Fiedler, Britta Gornott, Malte Morische, Luca D. Bertzbach, Thomas Dobner
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Various viral proteins are post-translationally modified by SUMO-conjugation during the human adenovirus (HAdV) replication cycle. This modification leads to diverse consequences for target proteins as it influences their intracellular localization o
Externí odkaz:
https://doaj.org/article/f3b7ef2bed9b4247a8f1514a7f3eb566
Publikováno v:
Tumour Virus Research, Vol 15, Iss , Pp 200254- (2023)
The human adenovirus species C type 5 (HAdV-C5) early region 4 (E4) encodes several distinct polypeptides, defined as E4orf1 to E4orf6/7 according to the order and arrangement of the corresponding open reading frames (ORFs). All E4 gene products oper
Externí odkaz:
https://doaj.org/article/c738b6b116184c248a6a6ba4f52977af
Autor:
Nafiseh Chalabi Hagkarim, Wing-Hang Ip, Luca D. Bertzbach, Tareq Abualfaraj, Thomas Dobner, David P. Molloy, Grant S. Stewart, Roger J. Grand
Publikováno v:
Viruses, Vol 15, Iss 12, p 2356 (2023)
The adenovirus C5 E1B-55K protein is crucial for viral replication and is expressed early during infection. It can interact with E4orf6 to form a complex that functions as a ubiquitin E3 ligase. This complex targets specific cellular proteins and mar
Externí odkaz:
https://doaj.org/article/70c0ec2ab3a84553b93bda7fdf4c4449
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Human adenovirus 36 (HAdV-D36) can cause obesity in animal models, induces an adipogenic effect and increased adipocyte differentiation in cell culture. HAdV-D36 infection alters gene expression and the metabolism of the infected cells resulting in i
Externí odkaz:
https://doaj.org/article/29886bb3c12149fdb1171fcc47c58cbd
Autor:
Jana Boddin, Wing-Hang Ip, Britta Wilkens, Konstantin von Stromberg, Wilhelm Ching, Emre Koyuncu, Luca D. Bertzbach, Thomas Dobner
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Adenoviruses are very efficient high-capacity vaccine vectors and are common gene delivery systems. Despite their extensive use in preclinical models and clinical trials over the past decades, adenoviral vectors still require optimization. T
Externí odkaz:
https://doaj.org/article/6b97796efb694bdbb153ca8f21ee25d3
Autor:
Thomas Dobner, Luca D. Bertzbach
Publikováno v:
Viruses, Vol 15, Iss 2, p 514 (2023)
Adenoviruses are commonly used as efficient high-capacity vectors and excellent gene delivery vehicles [...]
Externí odkaz:
https://doaj.org/article/e52c9498f4c049ac9aa3a78ed6db685e
Autor:
Margarita Valdés Alemán, Luca D. Bertzbach, Thomas Speiseder, Wing Hang Ip, Ramón A. González, Thomas Dobner
Publikováno v:
Viruses, Vol 14, Iss 11, p 2428 (2022)
It is well established that human adenoviruses such as species C, types 2 and 5 (HAdV-C2 and HAdV-C5), induce a nearly complete shutoff of host-cell protein synthesis in the infected cell, simultaneously directing very efficient production of viral p
Externí odkaz:
https://doaj.org/article/ae532ec80eba48a080de84895af529d4
Autor:
Søren Pfitzner, Helga Hofmann-Sieber, Jens B Bosse, Linda E Franken, Kay Grünewald, Thomas Dobner
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008588 (2020)
The human adenovirus type 5 (HAdV5) causes disease of the upper and lower respiratory tract. The early steps of HAdV5 entry up to genome replication in the host nucleus have been extensively studied. However, late stages of infection remain poorly un
Externí odkaz:
https://doaj.org/article/0865f09891b14131b080df37ad4ebd6a
Autor:
Miona Stubbe, Julia Mai, Christina Paulus, Hans Christian Stubbe, Julia Berscheminski, Maryam Karimi, Samuel Hofmann, Elisabeth Weber, Kamyar Hadian, Ron Hay, Peter Groitl, Michael Nevels, Thomas Dobner, Sabrina Schreiner
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Human adenoviruses (HAdVs) have developed mechanisms to manipulate cellular antiviral measures to ensure proper DNA replication, with detailed processes far from being understood. Host cells repress incoming viral genomes through a network o
Externí odkaz:
https://doaj.org/article/d784e1e6eba148b3a70d9bc1131bb912
Autor:
Marie Fiedler, Wing-Hang Ip, Helga Hofmann-Sieber, Britta Wilkens, Francis K. Nkrumah, Wenli Zhang, Anja Ehrhardt, Luca D. Bertzbach, Thomas Dobner
Publikováno v:
Viruses, Vol 14, Iss 3, p 463 (2022)
The human adenovirus type C5 (HAdV-C5) E1B-55K protein is a multifunctional regulator of HAdV-C5 replication, participating in many processes required for maximal virus production. Its multifunctional properties are primarily regulated by post-transl
Externí odkaz:
https://doaj.org/article/0a49b2740d8945caa0ea7070fff80060