Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Thomas, De Vijlder"'
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Small molecule identification is a crucial task in analytical chemistry and life sciences. One of the most commonly used technologies to elucidate small molecule structures is mass spectrometry. Spectral library search of product ion spectra
Externí odkaz:
https://doaj.org/article/73ad185aefad4f4d9acc13963584d7e1
Autor:
Youzhong Liu, Aida Mrzic, Pieter Meysman, Thomas De Vijlder, Edwin P Romijn, Dirk Valkenborg, Wout Bittremieux, Kris Laukens
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226770 (2020)
Despite the increasing importance of non-targeted metabolomics to answer various life science questions, extracting biochemically relevant information from metabolomics spectral data is still an incompletely solved problem. Most computational tools t
Externí odkaz:
https://doaj.org/article/910f46af140d426c94eaecd6008330bb
Autor:
Annelies Agten, Piotr Prostko, Melvin Geubbelmans, Youzhong Liu, Thomas De Vijlder, Dirk Valkenborg
Publikováno v:
Metabolites, Vol 11, Iss 6, p 400 (2021)
Structural modifications of DNA and RNA molecules play a pivotal role in epigenetic and posttranscriptional regulation. To characterise these modifications, more and more MS and MS/MS- based tools for the analysis of nucleic acids are being developed
Externí odkaz:
https://doaj.org/article/264b08621d054998abed506b2734db2b
Autor:
Youzhong Liu, Yingjie Zhang, Tom Vennekens, Jennifer L. Lippens, Luc Duijsens, Danh Bui-Thi, Kris Laukens, Thomas de Vijlder
Publikováno v:
Analytical chemistry
Small molecule structure elucidation using tandem mass spectrometry (MS/MS) plays a crucial role in life science, bioanalytical, and pharmaceutical research. There is a pressing need for increased throughput of compound identification and transformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c6fd1060623cbad99ec95337dc3a54
https://hdl.handle.net/10067/1968220151162165141
https://hdl.handle.net/10067/1968220151162165141
Publikováno v:
Nucleic Acid Therapeutics. 31:341-350
Imetelstat (GRN163L) is a potent and specific telomerase inhibitor currently in clinical development for the treatment of hematological malignancies such as myelofibrosis and myelodysplastic syndrome. It is a 13-mer N3'-P5' thio-phosphoramidate oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac87bf25b1a074506880d7bb9417fdd0
https://doi.org/10.1089/nat.2020.0918
https://doi.org/10.1089/nat.2020.0918
Autor:
Jennifer Albaneze-Walker, Gregor Urbanietz, Andras Horvath, Stefano Lancianesi, Alejandro Gimenez Molina, Thomas De Vijlder, Mattijs Baeten, Martine Canters
Publikováno v:
The Journal of organic chemistry. 87(19)
Azido nucleosides couple with phosphoramidites via an initial iminophosphorane, which eliminates acrylonitrile to generate the coupled dimer P(V) product. The vulnerable phosphite triester intermediate is bypassed entirely, making the methodology ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca3f94cb9f0cdeeabe6514bfa045fa6
https://pubmed.ncbi.nlm.nih.gov/36161801
https://pubmed.ncbi.nlm.nih.gov/36161801
Autor:
Tom Atherton, Carl Heatherington, Ulrike Rieder, Robert Peter, Thomas De Vijlder, Rainer Wechselberger, Francis Ring, Joerg Hoernschemeyer, Jessica A. Stolee, David Benstead, Ayman Charaf, Hong Jiang, Daniel C. Capaldi, Nadim Akhtar
Publikováno v:
Nucleic Acid Therapeutics. 30:249-264
A risk-based approach for routine identity testing of therapeutic oligonucleotide drug substances and drug products is described. Risk analysis of solid-phase oligonucleotide synthesis indicates that intact mass measurement is a powerful technique fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25dac9cb2bebc07dd39c91980bc3e71
https://doi.org/10.1089/nat.2020.0878
https://doi.org/10.1089/nat.2020.0878
Autor:
Andreas Marx, Niklas J. Koehl, René Holm, Brendan T. Griffin, John J. Keating, Thomas De Vijlder, Martin Kuentz, Laura J. Henze
Publikováno v:
Koehl, N J, Henze, L J, Holm, R, Kuentz, M, Keating, J J, De Vijlder, T, Marx, A & Griffin, B T 2022, ' Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax ', Journal of Pharmaceutical Sciences, vol. 111, no. 1, pp. 164-174 . https://doi.org/10.1016/j.xphs.2021.09.008
Lipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF vehicles. This study investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891f5094421f520bc605cb9eabbe0467
https://portal.findresearcher.sdu.dk/da/publications/8739040f-91e7-49b7-ae10-38595606aa5f
https://portal.findresearcher.sdu.dk/da/publications/8739040f-91e7-49b7-ae10-38595606aa5f
Publikováno v:
Rapid Communications in Mass Spectrometry.
RATIONALE Structure elucidation of small molecules has been one of the cornerstone applications of mass spectrometry for decades. Despite the increasing availability of software tools, structure elucidation from tandem mass spectrometry (MS/MS) data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51730e5177377c36fdb08d625e5d9119
https://doi.org/10.1002/rcm.9120
https://doi.org/10.1002/rcm.9120
Publikováno v:
Nucleic acid therapeutics. 31(5)
Imetelstat (GRN163L) is a potent and specific telomerase inhibitor currently in clinical development for the treatment of hematological malignancies such as myelofibrosis and myelodysplastic syndrome. It is a 13-mer N3'-P5' thio-phosphoramidate oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efc927eca51d961e95e2f7b4143496e6
https://pubmed.ncbi.nlm.nih.gov/34018844
https://pubmed.ncbi.nlm.nih.gov/34018844