Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Thomas, Dalsgaard"'
Autor:
Jacob Nielsen, Thomas Dalsgaard, Dorte Clausen, Lasse Folkersen, Lars Kyhn Rasmussen, Makhala M. Khammy, Claus Tornby Christoffersen, Peter Hjørringgaard Larsen, Morten Grunnet, Jan Kehler, Christian Aalkjaer
Publikováno v:
British Journal of Pharmacology. 174:4186-4198
Background and Purpose PDE1, a subfamily of cyclic nucleotide PDEs consisting of three isoforms, PDE1A, PDE1B and PDE1C, has been implicated in the regulation of vascular tone. The PDE1 isoform(s) responsible for tone regulation is unknown. This stud
Autor:
Anker Jon Hansen, Katerina Tritsaris, Christian Aalkjaer, Cecilie Egholm, Aleksandra Mazur, Thomas Dalsgaard, Steen Dissing, Makhala M. Khammy
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 311:H1214-H1224
We investigated the acute effects of glucagon-like peptide-1 (GLP-1), GLP-1(1–36), and GLP-1(7–36) on vascular endothelial growth factor-A (VEGFA)-induced endothelium-dependent signaling and vasodilation. Our hypothesis was that GLP-1 released fr
Publikováno v:
The Journal of Physiology. 594:3271-3285
Key points Increase in endothelial cell (EC) calcium activates calcium-sensitive intermediate and small conductance potassium (IK and SK) channels, thereby causing hyperpolarization and endothelium-dependent vasodilatation. Endothelial cells express
Publikováno v:
British Journal of Pharmacology. 173:1478-1490
Background and Purpose KCNQ-encoded voltage-dependent potassium channels (Kv7) are involved in the regulation of vascular tone. In this study we evaluated the influence of Kv7 channel activation on smooth muscle relaxation in rat penile arteries and
Autor:
Samuel N. Baldwin, Iain A. Greenwood, Henry R. Askew Page, Søren Peter Olesen, Thomas A. Jepps, Thomas Dalsgaard, Oleksandr V. Povstyan
Publikováno v:
Br J Pharmacol
Background and Purpose: Coronary artery disease leads to ischaemic heart disease and ultimately myocardial infarction. Thus, it is important to determine the factors that regulate coronary blood flow. Ca2+‐activated chloride channels contribute to
K V 7.2–7.5 Channel‐Activation Contributes to Bladder Relaxation Induced by Oxybutynin or Mirabegron
Publikováno v:
The FASEB Journal. 32
Autor:
Christine Wandall-Frostholm, Ralf Köhler, Susie Mogensen, Edgaras Stankevičius, Vytis Bajoriūnas, Thomas Dalsgaard, Ulf Simonsen, Veeruanjaneyulu Sadda, Lilliana Beck, Aida Oliván-Viguera
Publikováno v:
British Journal of Pharmacology. 172:4493-4505
Background and Purpose The intermediate conductance calcium/calmodulin-regulated K+ channel KCa3.1 produces hyperpolarizing K+ currents that counteract depolarizing currents carried by transient receptor potential (TRP) channels, and provide the elec
Autor:
Makhala Michell, Khammy, Thomas, Dalsgaard, Peter Hjørringgaard, Larsen, Claus Tornby, Christoffersen, Dorte, Clausen, Lars Kyhn, Rasmussen, Lasse, Folkersen, Morten, Grunnet, Jan, Kehler, Christian, Aalkjaer, Jacob, Nielsen
Publikováno v:
British journal of pharmacology. 174(22)
PDE1, a subfamily of cyclic nucleotide PDEs consisting of three isoforms, PDE1A, PDE1B and PDE1C, has been implicated in the regulation of vascular tone. The PDE1 isoform(s) responsible for tone regulation is unknown. This study used isoform-preferri
Autor:
Søren-Peter Olesen, Thomas Dalsgaard, Christel Kroigaard, Olga Kudryavtseva, Christine Wandall-Frostholm, Ulf Simonsen
Publikováno v:
Experimental Physiology. 98:957-969
Calcium-activated potassium channels of small (K(Ca)2, SK) and intermediate (K(Ca)3.1, IK) conductance are involved in endothelium-dependent relaxation of pulmonary arteries. We hypothesized that the function and expression of K(Ca)2 and K(Ca)3.1 inc
Publikováno v:
Dalsgaard, T, Sonkusare, S K, Teuscher, C, Poynter, M E & Nelson, M T 2016, ' Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice ', Scientific Reports, vol. 6, 33841 . https://doi.org/10.1038/srep33841
Scientific Reports
Scientific Reports
Sepsis is characterized by systemic inflammation, edema formation and hypo-perfusion leading to organ dysfunction and ultimately death. Activation of the transient receptor potential vanilloid type 4 (TRPV4) channel is associated with edema formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1c0eef69b6821689b2c89cf2bf318d
https://www.research.manchester.ac.uk/portal/en/publications/pharmacological-inhibitors-of-trpv4-channels-reduce-cytokine-production-restore-endothelial-function-and-increase-survival-in-septic-mice(29e69f69-f83f-48c8-b660-3c3efbff62cb).html
https://www.research.manchester.ac.uk/portal/en/publications/pharmacological-inhibitors-of-trpv4-channels-reduce-cytokine-production-restore-endothelial-function-and-increase-survival-in-septic-mice(29e69f69-f83f-48c8-b660-3c3efbff62cb).html