Zobrazeno 1 - 10
of 496
pro vyhledávání: '"Thomas, Carell"'
Autor:
Felix Xu, Dr. Stefan Wiedemann, Dr. Jonas Feldmann, Dr. Sidney Becker, Prof. Dr. Thomas Carell
Publikováno v:
ChemistryEurope, Vol 1, Iss 3, Pp n/a-n/a (2023)
Abstract The RNA world hypothesis predicts that life started with the development of replicating and catalytically active RNA, which evolved in a process of molecular evolution to increasingly complex chemical structures. RNA is, however, so complex
Externí odkaz:
https://doaj.org/article/16724e5aa08c462b8b4a4c80df9510a5
Autor:
Anna Nieborak, Saulius Lukauskas, Jordi Capellades, Patricia Heyn, Gabriela Silva Santos, Karsten Motzler, Anja Zeigerer, Romina Bester, Ulrike Protzer, Florian Schelter, Mirko Wagner, Thomas Carell, Alexander Hruscha, Bettina Schmid, Oscar Yanes, Robert Schneider
Publikováno v:
Molecular Metabolism, Vol 74, Iss , Pp 101748- (2023)
Objective: Cancer cells convert more glucose into lactate than healthy cells, what contributes to their growth advantage. Pyruvate kinase (PK) is a key rate limiting enzyme in this process, what makes it a promising potential therapeutic target. Howe
Externí odkaz:
https://doaj.org/article/1cdb8cc6c3104464995700a9b14eb2eb
Autor:
María Arroyo, Florian D. Hastert, Andreas Zhadan, Florian Schelter, Susanne Zimbelmann, Cathia Rausch, Anne K. Ludwig, Thomas Carell, M. Cristina Cardoso
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-28 (2022)
A short isoform of the Tet1 enzyme (Tet1s) that oxidizes the DNA 5-methylcytosine (5mC) mark is overexpressed in tumors. Here the authors show Tet1s, but not full length Tet1, changes localization over the cell cycle upon ubiquitination and Uhrf1 int
Externí odkaz:
https://doaj.org/article/4bd2bce040994572835707652c0ebd76
Autor:
Jonas Feldmann, Mads K. Skaanning, Marcus Lommel, Tobias Kernmayr, Dr. Peter Mayer, Prof. Dr. Thomas Carell
Publikováno v:
ChemistryEurope, Vol 1, Iss 1, Pp n/a-n/a (2023)
Abstract The question of how nucleosides might have formed as essential precursor molecules on the early Earth is one of the many challenges associated with the origin of life. In this context, the prebiotic synthesis of pyrimidine nucleosides is con
Externí odkaz:
https://doaj.org/article/25c48611a0fb4410bcfa8621f83fa7a4
Autor:
Michael A Margreiter, Monika Witzenberger, Yasmine Wasser, Elena Davydova, Robert Janowski, Jonas Metz, Pardes Habib, Sabri E.M. Sahnoun, Carina Sobisch, Benedetta Poma, Oscar Palomino-Hernandez, Mirko Wagner, Thomas Carell, N. Jon Shah, Jörg B. Schulz, Dierk Niessing, Aaron Voigt, Giulia Rossetti
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 443-458 (2022)
Polyglutamine (polyQ) diseases are characterized by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats encoding for an uninterrupted prolonged polyQ tract. We previously identified TRMT2A as a strong modifier of polyQ-induced toxici
Externí odkaz:
https://doaj.org/article/b64bb5ae313246c5aac74fe4b11f4b6c
Autor:
Markus Hillmeier, Mirko Wagner, Timm Ensfelder, Eva Korytiakova, Peter Thumbs, Markus Müller, Thomas Carell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Mannosyl-queuosine (manQ) is a non-canonical RNA nucleoside present in the anticodon loop of certain tRNAs. Here, the authors use a combination of total synthesis and mass spectrometry to contradict the literature-reported structure and show that man
Externí odkaz:
https://doaj.org/article/2119a9a6818e481084ae1938daeef0a4
Autor:
Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis, Thomas Carell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is red
Externí odkaz:
https://doaj.org/article/135f870c99dd4995a292de8aef187119
Autor:
María Arroyo, Florian D. Hastert, Andreas Zhadan, Florian Schelter, Susanne Zimbelmann, Cathia Rausch, Anne K. Ludwig, Thomas Carell, M. Cristina Cardoso
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/f3d86993de65494b9a523388754a4850
Autor:
Christopher B. Mulholland, Atsuya Nishiyama, Joel Ryan, Ryohei Nakamura, Merve Yiğit, Ivo M. Glück, Carina Trummer, Weihua Qin, Michael D. Bartoschek, Franziska R. Traube, Edris Parsa, Enes Ugur, Miha Modic, Aishwarya Acharya, Paul Stolz, Christoph Ziegenhain, Michael Wierer, Wolfgang Enard, Thomas Carell, Don C. Lamb, Hiroyuki Takeda, Makoto Nakanishi, Sebastian Bultmann, Heinrich Leonhardt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-24 (2020)
Active and passive demethylation pathways have been implicated in the genome-wide erasure of 5mC accompanying mammalian preimplantation development. Here the authors reveal a recently evolved, mammalian-specific pathway in which global hypomethylatio
Externí odkaz:
https://doaj.org/article/de4c9930854d459f81d5177982c48222
Autor:
Emily C. Beckwitt, Sunbok Jang, Isadora Carnaval Detweiler, Jochen Kuper, Florian Sauer, Nina Simon, Johanna Bretzler, Simon C. Watkins, Thomas Carell, Caroline Kisker, Bennett Van Houten
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
It is not fully understood how XPA interacts with a DNA lesion during nucleotide excision repair. Here, the authors use single molecule analysis to study XPA–DNA interactions, including the DNA bend angle, protein stoichiometry, and diffusive prope
Externí odkaz:
https://doaj.org/article/cb2429af2c074e93843b6cd1c155ebba