Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Thomas, Bettecken"'
Autor:
Broder Fredrich, Marcus Schmöhl, Olaf Junge, Sven Gundlach, David Ellinghaus, Arne Pfeufer, Thomas Bettecken, Roman Siddiqui, Andre Franke, Thomas F Wienker, Marc P Hoeppner, Michael Krawczak
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215618 (2019)
Massively parallel DNA sequencing of clinical samples holds great promise for the gene-based diagnosis of human inherited diseases because it allows rapid detection of putatively causative mutations at genome-wide level. Without additional evidence c
Externí odkaz:
https://doaj.org/article/1c9f50136d8a459098b9a522535bc363
Autor:
Julia Brenndörfer, André Altmann, Regina Widner-Andrä, Benno Pütz, Darina Czamara, Erik Tilch, Tony Kam-Thong, Peter Weber, Monika Rex-Haffner, Thomas Bettecken, Andrea Bultmann, Bertram Müller-Myhsok, Elisabeth E Binder, Rainer Landgraf, Ludwig Czibere
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128465 (2015)
Genomic copy number variants (CNVs) have been implicated in multiple psychiatric disorders, but not much is known about their influence on anxiety disorders specifically. Using next-generation sequencing (NGS) and two additional array-based genotypin
Externí odkaz:
https://doaj.org/article/c4ac5d6310824b8194e1d021c0bb4634
Autor:
Claire L Simpson, Robert Wojciechowski, Konrad Oexle, Federico Murgia, Laura Portas, Xiaohui Li, Virginie J M Verhoeven, Veronique Vitart, Maria Schache, S Mohsen Hosseini, Pirro G Hysi, Leslie J Raffel, Mary Frances Cotch, Emily Chew, Barbara E K Klein, Ronald Klein, Tien Yin Wong, Cornelia M van Duijn, Paul Mitchell, Seang Mei Saw, Maurizio Fossarello, Jie Jin Wang, DCCT/EDIC Research Group, Ozren Polašek, Harry Campbell, Igor Rudan, Ben A Oostra, André G Uitterlinden, Albert Hofman, Fernando Rivadeneira, Najaf Amin, Lennart C Karssen, Johannes R Vingerling, Angela Döring, Thomas Bettecken, Goran Bencic, Christian Gieger, H-Erich Wichmann, James F Wilson, Cristina Venturini, Brian Fleck, Phillippa M Cumberland, Jugnoo S Rahi, Chris J Hammond, Caroline Hayward, Alan F Wright, Andrew D Paterson, Paul N Baird, Caroline C W Klaver, Jerome I Rotter, Mario Pirastu, Thomas Meitinger, Joan E Bailey-Wilson, Dwight Stambolian
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107110 (2014)
Refractive error (RE) is a complex, multifactorial disorder characterized by a mismatch between the optical power of the eye and its axial length that causes object images to be focused off the retina. The two major subtypes of RE are myopia (nearsig
Externí odkaz:
https://doaj.org/article/2203e6a3cdb8432caf8445d80c0c2ecc
Autor:
Kerstin Knies, Beatrice Schuster, Najim Ameziane, Martin Rooimans, Thomas Bettecken, Johan de Winter, Detlev Schindler
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52648 (2012)
Fanconi anemia (FA) is a rare genomic instability syndrome. Disease-causing are biallelic mutations in any one of at least 15 genes encoding members of the FA/BRCA pathway of DNA-interstrand crosslink repair. Patients are diagnosed based upon phenoty
Externí odkaz:
https://doaj.org/article/09879af4485c464dbf1d46832950de2c
Autor:
Mirjam Bunck, Ludwig Czibere, Charlotte Horvath, Cornelia Graf, Elisabeth Frank, Melanie S Kessler, Chris Murgatroyd, Bertram Müller-Myhsok, Mariya Gonik, Peter Weber, Benno Pütz, Patrik Muigg, Markus Panhuysen, Nicolas Singewald, Thomas Bettecken, Jan M Deussing, Florian Holsboer, Dietmar Spengler, Rainer Landgraf
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5129 (2009)
BackgroundTo investigate neurobiological correlates of trait anxiety, CD1 mice were selectively bred for extremes in anxiety-related behavior, with high (HAB) and low (LAB) anxiety-related behavior mice additionally differing in behavioral tests refl
Externí odkaz:
https://doaj.org/article/d662c4ada68a48ea8d5efe51981ae446
Autor:
Thomas Bettecken, Edward N Trifonov
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7654 (2009)
It is generally accepted that the organization of eukaryotic DNA into chromatin is strongly governed by a code inherent in the genomic DNA sequence. This code, as well as other codes, is superposed on the triplets coding for amino acids. The history
Externí odkaz:
https://doaj.org/article/5f464046ddea448ab6637012948ee628
Autor:
Michael Krawczak, Broder Fredrich, Arne Pfeufer, Marc P. Hoeppner, Thomas Bettecken, Roman A. Siddiqui, Andre Franke, Thomas F. Wienker, David Ellinghaus, Marcus Schmöhl, Olaf Junge, Sven Gundlach
Publikováno v:
PLoS ONE
PLoS One
PLoS ONE, Vol 14, Iss 4, p e0215618 (2019)
PLoS One
PLoS ONE, Vol 14, Iss 4, p e0215618 (2019)
Massively parallel DNA sequencing of clinical samples holds great promise for the gene-based diagnosis of human inherited diseases because it allows rapid detection of putatively causative mutations at genome-wide level. Without additional evidence c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4941237ec2cd46ad7fe7e1b6ce33d94
http://europepmc.org/articles/PMC6483337
http://europepmc.org/articles/PMC6483337
Autor:
Bernd C. Kieseier, Hayrettin Tumani, Andreas Ziegler, Benjamin Knier, Antonios Bayas, Bertram Müller-Myhsok, Peter Lichtner, Verena Loleit, S. Nischwitz, Stefan Herms, Andrew T. Chan, Dorothea Buck, Andre Franke, Lukas Bechmann, Ulf Ziemann, Tania Kümpfel, Michael Pütz, Till F. M. Andlauer, Susanne Moebus, Karl-Heinz Jöckel, Wolfgang Lieb, Tobias Ruck, Theresa Dankowski, Florian Then Bergh, Sven G. Meuth, Ralf A. Linker, Heinz Wiendl, Carmen Infante-Duarte, Anke Salmen, Ralf Gold, M. Knop, Christina M. Lill, Thomas Bettecken, Volker Limmroth, Uwe K. Zettl, Melanie Waldenberger, Michael Hecker, Christiane Graetz, Martin Stangel, Konstantin Strauch, Markus M. Nöthen, Jürgen Haas, Jan-Patrick Stellmann, Björn Tackenberg, Gisela Antony, Bernhard Hemmer, Klarissa Hanja Stürner, Frauke Zipp, Frank Weber, Brigitte Wildemann, Friedemann Paul, Achim Berthele
Publikováno v:
Genetic Epidemiology. 39:601-608
Genome-wide association studies (GWAS) successfully identified various chromosomal regions to be associated with multiple sclerosis (MS). The primary aim of this study was to replicate reported associations from GWAS using an exome array in a large G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbf22ec9611ddd981a34c20f688a1e16
https://doi.org/10.1002/gepi.21933
https://doi.org/10.1002/gepi.21933
Autor:
R. Siddiqui, Thomas F. Wienker, Thomas Bettecken, Michael Krawczak, A. Pfeufer, R. Sudbrak, Andre Franke
Publikováno v:
Medizinische Genetik. 26:21-27
Zusammenfassung Next Generation Sequencing (NGS) erlaubt die Untersuchung des kompletten Exoms oder Genoms eines Patienten mit vertretbarem zeitlichem und finanziellem Aufwand. Dieser diagnostische Quantensprung hat neben rechtlichen, ethischen und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ef211b19fcd4a7977281034186bf730
https://doi.org/10.1007/s11825-014-0433-0
https://doi.org/10.1007/s11825-014-0433-0
Autor:
T. Dose, Thomas Bettecken, Stephan Ripke, Florian Holsboer, Susanne Lucae, Peter McGuffin, Elisabeth B. Binder, Daria Salyakina, Benno Pütz, Simone Reppermund, Torsten Klengel, Martin A. Kohli, Johannes M. Hennings, Marcus Ising, Roy H. Perlis, Steven P. Hamilton, Josef Zihl, Rudolf Uher, Tanja Brückl, Paul G. Unschuld, Bertram Müller-Myhsok, Manfred Uhr, Stefan Kloiber
Publikováno v:
European Neuropsychopharmacology. 23:653-662
Leptin, a peptide hormone from adipose tissue and key player in weight regulation, has been suggested to be involved in sleep and cognition and to exert antidepressant-like effects, presumably via its action on the HPA-axis and hippocampal function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccba059b850ea2bde7527ff2ca125d7
https://doi.org/10.1016/j.euroneuro.2012.08.010
https://doi.org/10.1016/j.euroneuro.2012.08.010