Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Thom M Molenaar"'
Autor:
Hanneke Vlaming, Thom M Molenaar, Tibor van Welsem, Deepani W Poramba-Liyanage, Desiree E Smith, Arno Velds, Liesbeth Hoekman, Tessy Korthout, Sjoerd Hendriks, AF Maarten Altelaar, Fred van Leeuwen
Publikováno v:
eLife, Vol 5 (2016)
Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However, systematic screening for epigenetic regulators is challenging and often relies on laborious ass
Externí odkaz:
https://doaj.org/article/e595d7f77f3849ec8660431a9e2c8ef7
Publikováno v:
Epigenetics, Vol 15, Iss 9, Pp 901-913 (2020)
In eukaryotes, nucleosomes form a barrier to DNA templated reactions and must be dynamically disrupted to provide access to the genome. During nucleosome (re)assembly, histones can be replaced by new histones, erasing post-translational modifications
Externí odkaz:
https://doaj.org/article/34abaaa08dc04d8cac74ce00d21ad4c1
Autor:
Janne J.M. van Schie, Klaas de Lint, Thom M. Molenaar, Macarena Moronta Gines, Jesper A. Balk, Martin A. Rooimans, Khashayar Roohollahi, Govind M. Pai, Lauri Borghuis, Anisha R. Ramadhin, Josephine C. Dorsman, Kerstin S. Wendt, Rob M.F. Wolthuis, Job de Lange
The cohesin complex regulates higher order chromosome architecture through maintaining sister chromatid cohesion and folding chromatin by active DNA loop extrusion. Impaired cohesin function underlies a heterogeneous group of genetic syndromes and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c6e041a48df0e13e5f4d4f39f963111
https://doi.org/10.1101/2022.12.23.521474
https://doi.org/10.1101/2022.12.23.521474
Autor:
Thom M. Molenaar, Eliza Mari Kwesi-Maliepaard, Joana Silva, Muddassir Malik, William J. Faller, Fred van Leeuwen
Cell size varies between cell types but is tightly regulated by cell-intrinsic and extrinsic mechanisms. Cell-size control is important for cell function and changes in cell size are frequently observed in cancer cells. Here we uncover a non-canonica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41c2de764f9b2a2c7988413b9fb683cc
https://doi.org/10.1101/2021.10.31.465891
https://doi.org/10.1101/2021.10.31.465891
Autor:
Tessy Korthout, A. F. Maarten Altelaar, Eliza Mari Kwesi-Maliepaard, Liesbeth Hoekman, Sjoerd Hendriks, Sander Palit, Thierry Schmidlin, Heinz Jacobs, Mir Farshid Alemdehy, Jan Hermen Dannenberg, Sjoerd Klarenbeek, Fred van Leeuwen, Cesare Lancini, Tibor van Welsem, Chelsea M. McLean, Hanneke Vlaming, Thom M Molenaar
Publikováno v:
EMBO Journal, 38(14). Nature Publishing Group
The EMBO Journal
EMBO journal, 38(14):e101564. Wiley-Blackwell
The EMBO Journal
EMBO journal, 38(14):e101564. Wiley-Blackwell
DOT1L methylates histone H3K79 and is aberrantly regulated in MLL‐rearranged leukemia. Inhibitors have been developed to target DOT1L activity in leukemia, but cellular mechanisms that regulate DOT1L are still poorly understood. We have identified
Autor:
Haico van Attikum, Kirsten van Harten, Iris J. E. Stulemeijer, Trey Ideker, Rohith Srivas, Fred van Leeuwen, Su Ming Sun, Farid El Oualid, Hanneke Vlaming, Tineke L. Lenstra, Dominique Morais, Tibor van Welsem, Huib Ovaa, Frank C. P. Holstege, Tessy Korthout, Reggy Ekkebus, Deepani W. Poramba-Liyanage, Thom M Molenaar
Publikováno v:
Nucleic Acids Research
Nucleic acids research, 46(21), 11251-11261. Oxford University Press
Nucleic Acids Research, 46(21), 11251-11261
Nucleic acids research, 46(21), 11251-11261. Oxford University Press
Nucleic Acids Research, 46(21), 11251-11261
The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine 79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects gene expression and the response to DNA damage, and is enhanced by mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca968c97e6ee05a0158c1e40575b5132
https://hdl.handle.net/1887/86410
https://hdl.handle.net/1887/86410
Autor:
Deepani W. Poramba-Liyanage, Hanneke Vlaming, Thom M Molenaar, A. F. Maarten Altelaar, Tessy Korthout, Liesbeth Hoekman, Sjoerd Hendriks, Tibor van Welsem, Fred van Leeuwen, Arno Velds, Desirée E.C. Smith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0f44c434ad6a09f615731fce84520f
https://doi.org/10.7554/elife.18919.036
https://doi.org/10.7554/elife.18919.036